IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ jinesh-2017-4 human-urinary_bladder_carcinoma Human urinary bladder carcinoma Human urinary_bladder_carcinoma urinary bladder carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Jinesh GG., Manyam GC., Mmeje CO., Baggerly KA., Kamat AM. The interaction was found in trypsin-resistant epithelial (UCAPe) cells derived from ascitic liquid found in a human bladder cancer patient. GJGerald@mdanderson.org,akamat@mdanderson.org Scientific reports 2017 Only protein-protein interactions imex curation jinesh-2017-2 human-urinary_bladder_carcinoma Human urinary bladder carcinoma Human urinary_bladder_carcinoma urinary bladder carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Jinesh GG., Manyam GC., Mmeje CO., Baggerly KA., Kamat AM. The interaction was found in pellet (UCAPm) cells derived from ascitic liquid found in a human bladder cancer patient. GJGerald@mdanderson.org,akamat@mdanderson.org Scientific reports 2017 Only protein-protein interactions imex curation jinesh-2017-3 human-urinary_bladder_carcinoma Human urinary bladder carcinoma Human urinary_bladder_carcinoma urinary bladder carcinoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Jinesh GG., Manyam GC., Mmeje CO., Baggerly KA., Kamat AM. The interaction was found in flocculate (UCAFm) cells derived from ascitic liquid found in a human bladder cancer patient. GJGerald@mdanderson.org,akamat@mdanderson.org Scientific reports 2017 Only protein-protein interactions imex curation rala_human Ras-related protein Ral-A RAL RALA protein protein human Homo sapiens Human MAANKPKGQNSLALHKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIRDNYFRSGEGFLCVFSITEMESFAATADFREQILRVKEDENVPFLLVGNKSDLEDKRQVSVEEAKNRAEQWNVNYVETSAKTRANVDKVFFDLMREIRARKMEDSKEKNGKKKRKSLAKRIRERCCIL cadh1_human Cadherin-1 Epithelial cadherin Uvomorulin CAM 120/80 CDH1 CDHE UVO protein protein human Homo sapiens Human MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD rbp1_human RalA-binding protein 1 Ral-interacting protein 1 76 kDa Ral-interacting protein Dinitrophenyl S-glutathione ATPase RALBP1 RLIP1 RLIP76 RLIP protein protein human Homo sapiens Human MTECFLPPTSSPSEHRRVEHGSGLTRTPSSEEISPTKFPGLYRTGEPSPPHDILHEPPDVVSDDEKDHGKKKGKFKKKEKRTEGYAAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKSKDLTAADVVKQWKEKKKKKKPIQEPEVPQIDVPNLKPIFGIPLADAVERTMMYDGIRLPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDREESTNLEDYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVLKQVMKPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDLSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEEMNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIERLRAEIAEIQSRQQHGRSETEEYSSESESESEDEEELQIILEDLQRQNEELEIKNNHLNQAIHEEREAIIELRVQLRLLQMQRAKAEQQAQEDEEPEWRGGAVQPPRDGVLEPKAAKEQPKAGKEPAKPSPSRDRKETSI cdh1-ralbp1-1 1874048 N/A RalA 1874051 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A E-cadherin 1874052 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level native native N/A RalBP1 1874053 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level native native association association false false false 6a, 6b, 6c Verapamil (CHEBI:9948) and dasatinib (CHEBI:49375) reduced RalA activation and decreased the interaction of the bait with both preys. VEGF-A (P15692) increased RalA activation and its interaction with the bait, but reduced the amount of E-cadherin interacting. ralbp1-cdh1-1 1874049 N/A RalA 1874051 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A RalBP1 1874053 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level native native physical association physical association false false false 6a verapamil and dasatinib ralbp1-rala-1 1874050 N/A RalA 1874051 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level N/A RalBP1 1874053 unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level native native physical association physical association false false false 6a verapamil and dasatinib