UniProt UniProt http://www.uniprot.org prasad-2007-2 in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Prasad R., Liu Y., Deterding LJ., Poltoratsky VP., Kedar PS., Horton JK., Kanno S., Asagoshi K., Hou EW., Khodyreva SN., Lavrik OI., Tomer KB., Yasui A., Wilson SH. Transfected Flag-POLB/Polbeta has been described in PubMed 10197627 by the authors. FEN1 used in CoIP exp with purified proteins cannot be mapped as source information is missing. Host system for purified POLB described in Pubmed 8594388 (not available online) is not specified. wilson5@niehs.nih.gov Molecular cell 2007 imex curation Only protein-protein interactions prasad-2007-1 mouse-embryonic_fibroblast Mus musculus embryonic fibroblasts embryonic_fibroblast Embryonic fibroblast Fibroblasts taken from an embryonic as opposed to a foetal or adult source. Foetus is defined as the stage at which tissue diferentiation is initiated. Tissue taken from an embryonic as opposed to a foetal or adult source. Embryo is defined as the development stage prior to organ formation. anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Prasad R., Liu Y., Deterding LJ., Poltoratsky VP., Kedar PS., Horton JK., Kanno S., Asagoshi K., Hou EW., Khodyreva SN., Lavrik OI., Tomer KB., Yasui A., Wilson SH. Polbeta null MEF cells expressing (human) Flag-tagged POLB/Polbeta have been used Transfected Flag-POLB/Polbeta has been described in PubMed 10197627 by the authors. FEN1 used in CoIP exp with purified proteins cannot be mapped as source information is missing. Host system for purified POLB described in Pubmed 8594388 (not available online) is not specified. wilson5@niehs.nih.gov Molecular cell 2007 imex curation Only protein-protein interactions apex1_mouse DNA-(apurinic or apyrimidinic site) endonuclease Apex1 Ape Apex REF-1 Redox factor-1 Ref1 Apurinic-apyrimidinic endonuclease 1 APEX nuclease protein protein mouse Mus musculus Mouse MPKRGKKAAADDGEEPKSEPETKKSKGAAKKTEKEAAGEGPVLYEDPPDQKTSPSGKSATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLTHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFESFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKDLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTAYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL mint Repairs oxidative DNA damages in vitro. May have a role in protection against cell lethality and suppression of mutations. Removes the blocking groups from the 3'-termini of the DNA strand breaks generated by ionizing radiations and bleomycin fen1_mouse Flap endonuclease 1 Flap structure-specific endonuclease 1 Fen1 Fen-1 protein protein mouse Mus musculus Mouse MGIHGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSLMGMFYRTIRMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGMEEEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRVLQELGLNQEQFVDLCILLGSDYCESIRGIGAKRAVDLIQKHKSIEEIVRRLDPSKYPVPENWLHKEAQQLFLEPEVVDPESVELKWSEPNEEELVKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGPAKKKAKTGGAGKFRRGK hmgb1_mouse High mobility group protein B1 Hmgb1 Hmg-1 Hmg1 High mobility group protein 1 protein protein mouse Mus musculus Mouse MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE dpolb_human DNA polymerase beta POLB protein protein human Homo sapiens Human MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE apex1_human DNA-(apurinic or apyrimidinic site) endonuclease Apurinic-apyrimidinic endonuclease 1 APEX nuclease APE1 APEX1 APE APEX APX HAP1 REF1 REF-1 Redox factor-1 protein protein human Homo sapiens Human MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKIRSKALGSDHCPITLYLAL hmgb1_human High mobility group protein B1 HMGB1 HMG1 High mobility group protein 1 protein protein human Homo sapiens Human MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE hmgb1-apex1-1 1857722 N/A 1857724 unspecified role unspecified role prey prey N/A 1857725 unspecified role unspecified role prey prey N/A 1857726 unspecified role unspecified role bait bait N/A 1857727 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false association association false false false 6B polb-apex1-2 1857722 N/A 1857728 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A 1857729 unspecified role unspecified role prey prey purified purified human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 N/A 1857727 unspecified role unspecified role bait bait purified purified association association false false false 6C FEN1 is found associated but cannot be mapped to UniProt hmgb1-apex1-2 1857722 N/A 1857728 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A 1857729 unspecified role unspecified role bait bait purified purified human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 N/A 1857727 unspecified role unspecified role prey prey purified purified association association false false false 6D FEN1 is found associated but cannot be mapped to UniProt polb-apex1-1 1857723 N/A 1857724 unspecified role unspecified role prey prey N/A 1857725 unspecified role unspecified role prey prey N/A 1857726 unspecified role unspecified role prey prey N/A 1857727 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection n-terminus flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range false association association false false false 6A