UniProt UniProt http://www.uniprot.org wang-2004-5 in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Wang QL., Chen S., Esumi N., Swain PK., Haines HS., Peng G., Melia BM., McIntosh I., Heckenlively JR., Jacobson SG., Stone EM., Swaroop A., Zack DJ. Expression of recombinant proteins (IP fig 6A) according Ref. 73, De Spada et al (2001) PubMed:11580893. Origin of Crx accord. Ref 12, Chen et al (1997) PubMed:9390516. Origin of NRL accord. Ref 32, Mitton et al (2000) PubMed:10887186. dzak@bs.jhmi.edu Human molecular genetics 2004 imex curation mimix curation Only protein-protein interactions wang-2004-3 in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Wang QL., Chen S., Esumi N., Swain PK., Haines HS., Peng G., Melia BM., McIntosh I., Heckenlively JR., Jacobson SG., Stone EM., Swaroop A., Zack DJ. Expression of recombinant proteins (IP fig 6A) according Ref. 73, De Spada et al (2001) PubMed:11580893. Origin of Crx accord. Ref 12, Chen et al (1997) PubMed:9390516. Origin of NRL accord. Ref 32, Mitton et al (2000) PubMed:10887186. dzak@bs.jhmi.edu Human molecular genetics 2004 IMEx imex curation Only protein-protein interactions wang-2004-4 human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Wang QL., Chen S., Esumi N., Swain PK., Haines HS., Peng G., Melia BM., McIntosh I., Heckenlively JR., Jacobson SG., Stone EM., Swaroop A., Zack DJ. Expression of recombinant proteins (IP fig 6A) according Ref. 73, De Spada et al (2001) PubMed:11580893. Origin of Crx accord. Ref 12, Chen et al (1997) PubMed:9390516. Origin of NRL accord. Ref 32, Mitton et al (2000) PubMed:10887186. dzak@bs.jhmi.edu Human molecular genetics 2004 IMEx imex curation Only protein-protein interactions crx_bovin Cone-rod homeobox protein CRX protein protein bovin Bos taurus (Bovine) Bovine MMAYMNPGPHYSVNALALSGPSVDLMHPAVSYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGAQAKARPAKRKAGTSPRSSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPPLGGPALSPLSGPSVGPSLTQSPTSLSGQSYGTYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL nrl_human Neural retina-specific leucine zipper protein NRL D14S46E protein protein human Homo sapiens Human MALPPSPLAMEYVNDFDLMKFEVKREPSEGRPGPPTASLGSTPYSSVPPSPTFSEPGMVGATEGTRPGLEELYWLATLQQQLGAGEALGLSPEEAMELLQGQGPVPVDGPHGYYPGSPEETGAQHVQLAERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSSGPGSGDPSHLFL rx_mouse Retinal homeobox protein Rx Rax Rx Retina and anterior neural fold homeobox protein protein protein mouse Mus musculus Mouse MHLPGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLGAQPACPKAPAGGSESSPPAAPGFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKLSEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKWRRQEKLEVSSMKLQDSPLLSFSRSPPSSALAPLGTGPGSGSGPPGSALPLEPWLGPPLPGGGATALQSLPGFGPPGQGLPASYTPPPPFLNSAPLGPGLQQLGPPPAYPCAPAFGDKFSLEEAYPRNSSIAALRLKAKEHIQAIGKPWQAL rax2_bovin Retina and anterior neural fold homeobox protein 2 RAX2 QRX RAXL1 Q50-type retinal homeobox protein Retina and anterior neural fold homeobox-like protein 1 protein protein bovin Bos taurus (Bovine) Bovine MFLSPGEGPAAEGGGPGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEVPALPFARPPTMPLSLEPWLGPGPPAVPALPRLLGSGPGLQGSFGPHAFSPAFMDGFTLEEGSLRLLAKEHVQALDRAWPSA rax2_human Retina and anterior neural fold homeobox protein 2 RAX2 QRX RAXL1 Q50-type retinal homeobox protein Retina and anterior neural fold homeobox-like protein 1 protein protein human Homo sapiens Human MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRAWPPA crx_human Cone-rod homeobox protein CRX CORD2 protein protein human Homo sapiens Human MMAYMNPGPHYSVNALALSGPSVDLMHQAVPYPSAPRKQRRERTTFTRSQLEELEALFAKTQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGGQAKARPAKRKAGTSPRPSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLVASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPQLGGPALSPLSGPSVGPSLAQSPTSLSGQSYGAYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL nrl-crx-4 1853762 N/A 1853765 unspecified role unspecified role prey prey region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false homeobox domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false rabit-reticulocyte Oryctolagus cuniculus reticulocyte reticulocyte Reticulocytes N/A 1853766 unspecified role unspecified role bait bait N/A gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) 1853777 1853774 physical association physical association false false false 6C nrl-rax-1 1853762 N/A 1853767 unspecified role unspecified role prey prey region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false homeobox domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false rabit-reticulocyte Oryctolagus cuniculus reticulocyte reticulocyte Reticulocytes N/A 1853766 unspecified role unspecified role bait bait N/A gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) 1853784 1853781 physical association physical association false false false 6C crx-rax2-1 1853763 N/A 1853768 unspecified role unspecified role prey prey in vitro translated in vitro translated protein in vitro translated region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false homeobox domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false Q7YRX0:p.Gly137Arg mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false Corresponds to human G137R disease variant in CORD11 Q7YRX0:p.Ser138_Gly139insGlyPro mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain false rabit-reticulocyte Oryctolagus cuniculus reticulocyte reticulocyte Reticulocytes Mutation R87Q corresponding to human disease variant R87Q in ARMD6 is interacting N/A 1853765 unspecified role unspecified role bait bait in vitro translated in vitro translated protein in vitro translated homeobox domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false rabit-reticulocyte Oryctolagus cuniculus reticulocyte reticulocyte Reticulocytes 1853792 1853788 physical association physical association false false false 6A crx-rax2-2 1853764 N/A 1853769 unspecified role unspecified role prey prey nucl transfection nucleic acid transfection nucl transfection region xpress tag xpress tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 1853770 unspecified role unspecified role bait bait nucl transfection nucleic acid transfection nucl transfection region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 6B