IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ tosi-2013-1 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. yeast Saccharomyces cerevisiae Baker's yeast anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. FLAG-elution was further purified to near homogeneity by MonoQ ion exchange and Superose 6 size exclusion chromatography beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-7 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. chromatography chromatography technology column chromatography chromatography weight by comassie molecular weight estimation by coomasie staining weight by comassie Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-2 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. yeast Saccharomyces cerevisiae Baker's yeast electron microscopy electron microscopy Electron crystallography Electron cryomicroscopy Electron crystallography Electron cryomicroscopy predetermined predetermined participant predetermined Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. Both negative-stain (EMB-2385) and cryo-EM (EMD-2386) structures were obtained. beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-3 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. yeast Saccharomyces cerevisiae Baker's yeast crosslink cross-linking study crosslink sequence tag sequence tag identification sequence tag Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. Crosslinked with an equimolar mixture of d0- and d12-labeled disuccinimidyl suberate beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-5 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-6 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. yeast Saccharomyces cerevisiae Baker's yeast pull down pull down anti tag western anti tag western blot anti tag western Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation tosi-2013-8 Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex. in vitro In vitro crosslink cross-linking study crosslink sequence tag sequence tag identification sequence tag Tosi A., Haas C., Herzog F., Gilmozzi A., Berninghausen O., Ungewickell C., Gerhold C.B., Lakomek K., Aebersold R., Beckmann R., Hopfner K.P. Crosslinked with an equimolar mixture of d0- and d12-labeled disuccinimidyl suberate beckmann@genzentrum.lmu.de, hopfner@genzentrum.lmu.de Cell (0092-8674) 2013 Only protein-protein interactions imex curation act_yeast Actin ACT1 ABY1 END7 YFL039C protein protein yeast Saccharomyces cerevisiae Baker's yeast MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF 87AC19B0B0BC9E71 ruvb2_yeast RuvB-like protein 2 TIP49-homology protein 2 TIP49b homolog RVB2 TIH2 TIP49B YPL235W P1060 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSIQTSDPNETSDLKSLSLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNGTIAGRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKTEALTQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGADTRFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVMMATNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTILSIRAQEEEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNTVEVEDVKRAYLLFLDSARSVKYVQENESQYIDDQGNVQISIAKSADPDAMDTTE 0D8EFBA7EC711AB8 ies2_yeast Ino eighty subunit 2 N1315 YNL215W IES2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MDSEASDIEAELSDSVSAGGEEYIDDDDYTEDIDDQIVTAKSSRRTARRSVPKGVRTSKRIRDKELSVEVDEDYDEEEDVLSPSKKRHLHTRSMDKRQVAATASEKSDIGDSKGNDGEIEDGILEEEESLEKELNRGGGKEVEKSEESYYAQNDVGQKGEEEQDGESGGYEDNEPSISKESDELVSVVNGNGNEEDDEVEATKENTTDSTRSTTTRSKMLLDLLEDGGSKKKLTDEEIQLRRAENARKRKNLSEKRLEEEKQDTINKLLKKRAGKSRSHLPNDDEKNDGSSSFVKPRRPYNSEGMTRILRRYEEDLFCTF 6F0AA04387A3B3E8 ies6_yeast Chromatin-remodeling complex subunit IES6 YEL044W SYGP-ORF13 IES6 Ino eighty subunit 6 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSGSRGNSSNSSVSNNSNNNNNNDGGDERLLFLRSVGERNEIGFPSRFKSAHYKKPTRRHKSARQLISDENKRINALLTKANKAAESSTAARRLVPKATYFSVEAPPSIRPAKKYCDVTGLKGFYKSPTNNIRYHNAEIYQLIVKPMAPGVDQEYLKLRGANFVLK ruvb1_yeast RuvB-like protein 1 RVB1 TIP49-homology protein 1 TIP49a homolog TIH1 TIP49A YDR190C protein protein yeast Saccharomyces cerevisiae Baker's yeast MVAISEVKENPGVNSSNSGAVTRTAAHTHIKGLGLDESGVAKRVEGGFVGQIEAREACGVIVDLIKAKKMSGRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTETLMENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYESIQREKVSIGDVIYIEANTGAVKRVGRSDAYATEFDLETEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMGQLLKPKKTEITEKLRQEVNKVVAKYIDQGVAELIPGVLFIDEVNMLDIEIFTYLNKALESNIAPVVVLASNRGMTTVRGTEDVISPHGVPPDLIDRLLIVRTLPYDKDEIRTIIERRATVERLQVESSALDLLATMGTETSLRYALQLLAPCGILAQTSNRKEIVVNDVNEAKLLFLDAKRSTKILETSANYL 93D6ECB7006AF0F2 ies1_yeast Ino eighty subunit 1 IES1 YFL013C protein protein yeast Saccharomyces cerevisiae Baker's yeast MGKRVYDPIHDTFQLREDNSDETKADSPMQSVKSGSQEEASPSSIQSETETVTTKSIPVIHEIEIDDKNDDDSTQSEEENTNILLNFEPSTVPEATGASTATGPVTTNTVRRKPKESNASKYNRHLKKPDGEPFNRKDIQFSFMQELLMDKRQIFTNVLKPLYKNSIVPINIDGDKLSINVTDKEYDARTFVFNDKLTFAQLYVLTIATSIKCSKILRDKLLLDQQVAFSTCVLALLVNIGRLNTTINFYLEMTSQLRTFHSVPVLQLHANDPKLLQDTPRLKSILKNLPWGNEQLSLMETYKKVDQNDGEVDTVNKFNIINMLFSICDNSGLIDKRFLSKYVEVESKAQEQDMVDEQNEVKETEAENEKQESKAAYATTLFDILDYSKYEPKDRSNILIWLLYIHLETNLSQEEVEESVRFFNGLEDGAPAGKFILRCTERSYDTDPEDELEFGANQRIKRREFMSKMEEGRKRERTNVTEVKKPSIGGDKSEEDGEGEDDKSEETVEETRSLLTPTPILESSSPMTLNRKKVTPQLPKVTPAAPTETEEEITSAAIIDKNDLNLTPLKKYNSSATVNKVDKLISLDLNKHVSENGKTQEEFLADLKKSQVPNRLKRRDIGLIKIFNEFEDIPVASVLGIRGKKRKKFKDNLLGFETDFMKNLGASKKVLLNKIERAEIDDEEATAMFKLE 9C0084A36431B241 ies4_yeast Ino eighty subunit 4 YOR189W IES4 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSQESSVLSESQEQLANNPKIEDTSPPSANSRDNSKPVLPWDYKNKAIEIKSFSGYKVNFTGWIRRDVREERQRGSEFTASDVKGSDDKATRKKEPADEDPEVKQLEKEGEDGLDS ies3_yeast Ino eighty subunit 3 IES3 L2131 YLR052W protein protein yeast Saccharomyces cerevisiae Baker's yeast MKFEDLLATNKQVQFAHAATQHYKSVKTPDFLEKDPHHKKFHNADGLNQQGSSTPSTATDANAASTASTHTNTTTFKRHIVAVDDISKMNYEMIKNSPGNVITNANQDEIDISTLKTRLYKDNLYAMNDNFLQAVNDQIVTLNAAEQDQETEDPDLSDDEKIDILTKIQENLLEEYQKLSQKERKWFILKELLLDANVELDLFSNRGRKASHPIAFGAVAIPTNVNANSLAFNRTKRRKINKNGLLENIL 5A0A2229D6C87ABF arp4_yeast Actin-related protein 4 ARP4 ACT3 YJL081C J1012 Actin-like protein ARP4 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSNAALQVYGGDEVSAVVIDPGSYTTNIGYSGSDFPQSILPSVYGKYTADEGNKKIFSEQSIGIPRKDYELKPIIENGLVIDWDTAQEQWQWALQNELYLNSNSGIPALLTEPVWNSTENRKKSLEVLLEGMQFEACYLAPTSTCVSFAAGRPNCLVVDIGHDTCSVSPIVDGMTLSKSTRRNFIAGKFINHLIKKALEPKEIIPLFAIKQRKPEFIKKTFDYEVDKSLYDYANNRGFFQECKETLCHICPTKTLEETKTELSSTAKRSIESPWNEEIVFDNETRYGFAEELFLPKEDDIPANWPRSNSGVVKTWRNDYVPLKRTKPSGVNKSDKKVTPTEEKEQEAVSKSTSPAANSADTPNETGKRPLEEEKPPKENNELIGLADLVYSSIMSSDVDLRATLAHNVVLTGGTSSIPGLSDRLMTELNKILPSLKFRILTTGHTIERQYQSWLGGSILTSLGTFHQLWVGKKEYEEVGVERLLNDRFR 6DE1C8938C6C3DBB ies5_yeast Ino eighty subunit 5 YER092W IES5 protein protein yeast Saccharomyces cerevisiae Baker's yeast MPSKDPESVIDKEIRKISARNDELIKQDGTLKREYTTLLRKVSSVITVLNSIDDADTGSAETELPRLISQATVEKVPELKWYNDQISLITEKLEDDEDIEVPEELMDAYTLYKETPLLYNDTHTP arp5_yeast Actin-related protein 5 ARP5 YNL059C N2430 YNL2430C Actin-like protein ARP5 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSSRDASLTPLKAVVIDDPPLRQTPEPFDEQSAYNPQSPIAIDFGSSKLRAGFVNHATPTHIFPNALTKFRDRKLNKNFTFVGNDTLLDQAVRSQSRSPFDGPFVTNWNLTEEILDYTFHHLGVVPDNGIPNPILLTERLATVQSQRTNWYQILFETYNVPGVTFGIDSLFSFYNYNPSGNKTGLVISCGHEDTNVIPVVDGAGILTDAKRINWGGHQAVDYLNDLMALKYPYFPTKMSYLQYETMYKDYCYVSRNYDEDIEKILTLENLDTNDVVVEAPFTEVLQPQKTEEELRIQAEKRKETGKRLQEQARLKRMEKLVQKQEEFEYFSKVRDQLIDEPKKKVLSVLQNAGFDDERDFKKYLHSLEQSLKKAQMVEAEDDSHLDEMNEDKTAQKFDLLDIADEDLNEDQIKEKRKQRFLKASQDARQKAKEEKERVAKEEEEKKLKEQQWRETDLNGWIKDKRLKLNKLIKRRKEKLKLRDEMKDRKSQVSQNRMKNLASLAEDNVKQGAKRNRHQATIDNDPNDTFGANDEDWLIYTDITQNPEAFEEALEYEYKDIVELERLLLEHDPNFTEEDTLEAQYDWRNSILHLFLRGPRPHDSENIHEQHQMHLNVERIRVPEVIFQPTMGGQDQAGICELSETILLKKFGSQPGKLSQTSIDMVNNVLITGGNAKVPGLKERIVKEFTGFLPTGTNITVNMSSDPSLDAWKGMAALARNEEQYRKTVISKKEYEEYGPEYIKEHKLGNTKYFED arp8_yeast Actin-like protein ARP8 ARP8 YOR3348C YOR141C protein protein yeast Saccharomyces cerevisiae Baker's yeast MSQEEAESSIIYEEPIDIPLEDDDDEDELEEENSVPLSSQADQENAENESDDSVDNVVGSETPRSVTGLSVDPRDVADEEDEDEEGEDEDEDEDDNDVDNEDENDNDNANENENELGSSRDKRAPPAVQTSKRYKKYPKLDPAKAPPGKKVPLHLLEKRRLGRIKAAEEFAKTLKKIGIEKVETTTLPATGLFQPLMLINQKNYSSDYLKKDDQIFALRDRKFLRNNNTSQISSTNTPDVIDLKSLPHSEASAAPLNDEIDLNDPTATIVIHPGSNSIKIGFPKDDHPVVVPNCVAVPKKWLDLENSEHVENVCLQREQSEEFNNIKSEMEKNFRERMRYYKRKVPGNAHEQVVSFNENSKPEIISEKNDPSPIEWIFDDSKLYYGSDALRCVDEKFVIRKPFRGGSFNVKSPYYKSLAELISDVTKLLEHALNSETLNVKPTKFNQYKVVLVIPDIFKKSHVETFIRVLLTELQFQAVAIIQESLATCYGAGISTSTCVVNIGAAETRIACVDEGTVLEHSAITLDYGGDDITRLFALFLLQSDFPLQDWKIDSKHGWLLAERLKKNFTTFQDADVAVQLYNFMNRSPNQPTEKYEFKLFDEVMLAPLALFFPQIFKLIRTSSHKNSSLEFQLPESRDLFTNELNDWNSLSQFESKEGNLYCDLNDDLKILNRILDAHNIIDQLQDKPENYGNTLKENFAPLEKAIVQSIANASITADVTRMNSFYSNILIVGGSSKIPALDFILTDRINIWRPSLLSSASFPQFYKKLTKEIKDLEGHYVNAPDKTEDENKQILQAQIKEKIVEELEEQHQNIEHQNGNEHIFPVSIIPPPRDMNPALIIWKGASVLAQIKLVEELFITNSDWDVHGSRILQYKCIFTY 8174851B6B077A19 nhp10_yeast Non-histone protein 10 HMO2 YD8119.05C YDL002C NHP10 High mobility group protein 2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSVEEKKRRLEELKDQNVVLGLAIQRSRLSVKRLKLEYGVLLERLESRIELDPELNCEDPLPTLASFKQELLTKPFRKSKTKRHKVKERDPNMPKRPTNAYLLYCEMNKERIRQNGSLDVTRDLAEGWKNLNEQDRKPYYKLYSEDRERYQMEMEIYNKKISNIDADDDKEENEQKIKNNEEGSSTKVADSKGGEDGSLVSSN ino80_yeast Chromatin-remodeling ATPase INO80 YGL150C G1880 INO80 Inositol-requiring protein 80 protein protein yeast Saccharomyces cerevisiae Baker's yeast MSLAVLLNKEDKDISDFSKTTAGKSAKKNSRERVADVAPTRVLDKKQAYLSQLNSEFNRIKRRDSIEQLYQDWKFINLQEFELISEWNQQSKDWQFDNTNDSQDLHFKKLYRDMSMINKEWAEYQSFKNANLSDIINEKDADEDEEDDEDELEDGEEDMEEDEASTGRHTNGKSMRGNGIQKSRKKDAAAAAAIGKAIKDDQTHADTVVTVNGDENEDGNNGEDEDNDNDNENNNDNDNDNENENDNDSDNDDEEENGEEDEEEEEIEDLDEEDFAAFEEQDDNDDEDFNPDVEKRRKRSSSSSSSTKLSMNSLSLITSKKINKNITINSDRPKIVRELIKMCNKNKHQKIKKRRFTNCIVTDYNPIDSKLNIKITLKQYHVKRLKKLINDAKREREREEALKNNVGLDGNDLDNDEDGSESHKRRKLNNNTANGADDANKRKFNTRHGLPTYGMKMNAKEARAIQRHYDNTYTTIWKDMARKDSTKMSRLVQQIQSIRSTNFRKTSSLCAREAKKWQSKNFKQIKDFQTRARRGIREMSNFWKKNEREERDLKKKIEKEAMEQAKKEEEEKESKRQAKKLNFLLTQTELYSHFIGRKIKTNELEGNNVSSNDSESQKNIDISALAPNKNDFHAIDFDNENDEQLRLRAAENASNALAETRAKAKQFDDHANAHEEEEEEDELNFQNPTSLGEITIEQPKILACTLKEYQLKGLNWLANLYDQGINGILADEMGLGKTVQSISVLAHLAENHNIWGPFLVVTPASTLHNWVNEISKFLPQFKILPYWGNANDRKVLRKFWDRKNLRYNKNAPFHVMVTSYQMVVTDANYLQKMKWQYMILDEAQAIKSSQSSRWKNLLSFHCRNRLLLTGTPIQNSMQELWALLHFIMPSLFDSHDEFNEWFSKDIESHAEANTKLNQQQLRRLHMILKPFMLRRVKKNVQSELGDKIEIDVLCDLTQRQAKLYQVLKSQISTNYDAIENAATNDSTSNSASNSGSDQNLINAVMQFRKVCNHPDLFERADVDSPFSFTTFGKTTSMLTASVANNNSSVISNSNMNLSSMSSNNISNGKFTDLIYSSRNPIKYSLPRLIYEDLILPNYNNDVDIANKLKNVKFNIFNPSTNYELCLFLSKLTGEPSLNEFFRVSTTPLLKRVIERTNGPKNTDSLSFKTITQELLEVTRNAPSEGVMASLLNVEKHAYEREYLNCIQRGYHPNVSAPPVTIEVLGSSHVTNSINNELFDPLISQALSDIPAITQYNMHVKKGIPVEDFPKTGLFPEPLNKNFSSNISMPSMDRFITESAKLRKLDELLVKLKSEGHRVLIYFQMTKMMDLMEEYLTYRQYNHIRLDGSSKLEDRRDLVHDWQTNPEIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTIDSQAMDRAHRLGQTRQVTVYRLLVRGTIEERMRDRAKQKEQVQQVVMEGKTQEKNIKTIEVGENDSEVTREGSKSISQDGIKEAASALA 017053C5A245337E taf14_yeast Transcription initiation factor TFIID subunit 14 ANC1 CST10 YPL129W TAF14 SWP29 TAF30 TFG3 TBP-associated factor 14 TBP-associated factor 30 kDa Transcription initiation factor TFIIF 30 kDa subunit Transcription factor G 30 kDa subunit SWI/SNF chromatin-remodeling complex subunit TAF14 SWI/SNF complex subunit TAF14 SWI/SNF complex 29 kDa subunit Actin non-complementing mutant 1 Chromosome stability protein 10 protein protein yeast Saccharomyces cerevisiae Baker's yeast MVATVKRTIRIKTQQHILPEVPPVENFPVRQWSIEIVLLDDEGKEIPATIFDKVIYHLHPTFANPNRTFTDPPFRIEEQGWGGFPLDISVFLLEKAGERKIPHDLNFLQESYEVEHVIQIPLNKPLLTEELAKSGSTEETTANTGTIGKRRTTTNTTAEPKAKRAKTGSASTVKGSVDLEKLAFGLTKLNEDDLVGVVQMVTDNKTPEMNVTNNVEEGEFIIDLYSLPEGLLKSLWDYVKKNTE 60EA5EC2474B1B9C arp5_human Actin-related protein 5 Sarcoma antigen NY-SAR-16 ACTR5 ARP5 protein protein human Homo sapiens Human MAANVFPFRDARAAPDPVLEAGPVAHGPLPVPLVLDNGSFQVRAGWACPGQDPGPEPRLQFRAVCARGRGGARGASGPQVGNALGSLEPLRWMLRSPFDRNVPVNLELQELLLDYSFQHLGVSSQGCVDHPIVLTEAVCNPLYSRQMMSELLFECYGIPKVAYGIDSLFSFYHNKPKNSMCSGLIISSGYQCTHVLPILEGRLDAKNCKRINLGGSQAAGYLQRLLQLKYPGHLAAITLSRMEEILHEHSYIAEDYVEELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHKALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVFNLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQLASNPVLDAWYGARDWALNHLDDNEVWITRKEYEEKGGEYLKEHCASNIYVPIRLPKQASRSSDAQASSKGSAAGGGGAGEQA h3_drome Histone H3 His3 His3:CG31613 His3:CG33857 His3:CG33860 His3:CG33863 His3:CG33866 CG31613 CG33803 CG33806 CG33809 CG33812 CG33815 CG33818 CG33821 CG33824 CG33827 CG33830 CG33833 CG33836 CG33839 CG33842 CG33845 CG33848 CG33851 CG33854 CG33857 CG33860 CG33863 CG33866 His3:CG33803 His3:CG33806 His3:CG33809 His3:CG33812 His3:CG33815 His3:CG33818 His3:CG33821 His3:CG33824 His3:CG33827 His3:CG33830 His3:CG33833 His3:CG33836 His3:CG33839 His3:CG33842 His3:CG33845 His3:CG33848 His3:CG33851 His3:CG33854 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA h4_drome Histone H4 H4 His4r H4r CG3379 His4:CG31611 CG31611 His4 His4:CG33869 His4:CG33871 His4:CG33873 His4:CG33875 His4:CG33877 His4:CG33879 His4:CG33881 His4:CG33883 His4:CG33885 His4:CG33887 His4:CG33889 His4:CG33891 His4:CG33893 His4:CG33895 His4:CG33897 His4:CG33899 His4:CG33901 His4:CG33903 His4:CG33905 His4:CG33907 His4:CG33909 CG33869 CG33871 CG33873 CG33875 CG33877 CG33879 CG33881 CG33883 CG33885 CG33887 CG33889 CG33891 CG33893 CG33895 CG33897 CG33899 CG33901 CG33903 CG33905 CG33907 CG33909 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MTGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG h2b_drome Histone H2B His2B His2B:CG17949 His2B:CG33868 His2B:CG33870 His2B:CG33872 His2B:CG33874 His2B:CG33876 His2B:CG33878 His2B:CG33880 His2B:CG33882 His2B:CG33884 His2B:CG33886 His2B:CG33888 His2B:CG33890 His2B:CG33892 His2B:CG33894 His2B:CG33896 His2B:CG33898 His2B:CG33900 His2B:CG33902 His2B:CG33904 His2B:CG33906 His2B:CG33908 His2B:CG33910 CG17949 CG33868 CG33870 CG33872 CG33874 CG33876 CG33878 CG33880 CG33882 CG33884 CG33886 CG33888 CG33890 CG33892 CG33894 CG33896 CG33898 CG33900 CG33902 CG33904 CG33906 CG33908 CG33910 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MPPKTSGKAAKKAGKAQKNITKTDKKKKRKRKESYAIYIYKVLKQVHPDTGISSKAMSIMNSFVNDIFERIAAEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK h2a_drome Histone H2A His2A H2a His2A:CG31618 CG31618 His2A:CG33808 His2A:CG33814 His2A:CG33817 His2A:CG33820 His2A:CG33823 His2A:CG33826 His2A:CG33829 His2A:CG33832 His2A:CG33835 His2A:CG33838 His2A:CG33841 His2A:CG33844 His2A:CG33847 His2A:CG33850 His2A:CG33862 His2A:CG33865 CG33808 CG33814 CG33817 CG33820 CG33823 CG33826 CG33829 CG33832 CG33835 CG33838 CG33841 CG33844 CG33847 CG33850 CG33862 CG33865 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSGRGKGGKVKGKAKSRSNRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTEKKA ino80-act1-2 1455559 n/a 1455566 unspecified role unspecified role prey prey n/a 1455567 unspecified role unspecified role prey prey n/a 1455568 unspecified role unspecified role prey prey n/a 1455569 unspecified role unspecified role prey prey n/a 1455570 unspecified role unspecified role prey prey n/a 1455571 unspecified role unspecified role prey prey n/a 1455572 unspecified role unspecified role prey prey n/a 1455573 unspecified role unspecified role prey prey n/a 1455574 unspecified role unspecified role prey prey n/a 1455575 unspecified role unspecified role prey prey n/a 1455576 unspecified role unspecified role prey prey n/a 1455577 unspecified role unspecified role prey prey n/a 1455578 unspecified role unspecified role prey prey n/a 1455579 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455580 unspecified role unspecified role prey prey physical association physical association false false false Supp. Fig. 1A, 1B ino80-act1-5 1455559 n/a 1455574 unspecified role unspecified role prey prey n/a 1455577 unspecified role unspecified role prey prey n/a 1455567 unspecified role unspecified role prey prey n/a 1455576 unspecified role unspecified role prey prey n/a 1455575 unspecified role unspecified role prey prey n/a 1455571 unspecified role unspecified role prey prey n/a 1455568 unspecified role unspecified role prey prey n/a 1455569 unspecified role unspecified role prey prey n/a 1455580 unspecified role unspecified role prey prey n/a 1455573 unspecified role unspecified role prey prey n/a 1455566 unspecified role unspecified role prey prey n/a 1455572 unspecified role unspecified role prey prey n/a 1455579 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455578 unspecified role unspecified role prey prey n/a 1455570 unspecified role unspecified role prey prey physical association physical association false false false Fig.3, Sup. Tables 3 and 4 ino80-act1-6 1455559 n/a 1455575 unspecified role unspecified role prey prey n/a 1455571 unspecified role unspecified role prey prey n/a 1455566 unspecified role unspecified role prey prey n/a 1455572 unspecified role unspecified role prey prey n/a 1455573 unspecified role unspecified role prey prey n/a 1455579 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455568 unspecified role unspecified role prey prey n/a 1455570 unspecified role unspecified role prey prey n/a 1455580 unspecified role unspecified role prey prey n/a 1455578 unspecified role unspecified role prey prey n/a 1455567 unspecified role unspecified role prey prey n/a 1455577 unspecified role unspecified role prey prey n/a 1455574 unspecified role unspecified role prey prey physical association physical association false false false Fig. 3B Interaction observed in Arp5-/- cells ino80-act1-9 1455559 n/a 1455580 unspecified role unspecified role prey prey n/a 1455579 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455573 unspecified role unspecified role prey prey n/a 1455570 unspecified role unspecified role prey prey n/a 1455567 unspecified role unspecified role prey prey n/a 1455569 unspecified role unspecified role prey prey n/a 1455571 unspecified role unspecified role prey prey n/a 1455575 unspecified role unspecified role prey prey n/a 1455578 unspecified role unspecified role prey prey n/a 1455574 unspecified role unspecified role prey prey n/a 1455576 unspecified role unspecified role prey prey n/a 1455568 unspecified role unspecified role prey prey n/a 1455566 unspecified role unspecified role prey prey physical association physical association false false false Fig.3B Interaction observed in ARP8-/- cells. Taf14 and Actin were present in reduced amounts. ino80-act1-7 1455559 n/a 1455576 unspecified role unspecified role prey prey n/a 1455567 unspecified role unspecified role prey prey n/a 1455570 unspecified role unspecified role prey prey n/a 1455574 unspecified role unspecified role prey prey n/a 1455577 unspecified role unspecified role prey prey n/a 1455572 unspecified role unspecified role prey prey n/a 1455579 unspecified role unspecified role bait bait c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455566 unspecified role unspecified role prey prey n/a 1455569 unspecified role unspecified role prey prey n/a 1455568 unspecified role unspecified role prey prey n/a 1455580 unspecified role unspecified role prey prey physical association physical association false false false Fig.3B Interaction observed in Nhp10-/- cells act1-arp4-18 1455560 n/a 1455572 unspecified role unspecified role unspecified role unspecified role region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1455579 unspecified role unspecified role unspecified role unspecified role hsa region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1455574 unspecified role unspecified role unspecified role unspecified role n/a 1455577 unspecified role unspecified role unspecified role unspecified role n/a 1455566 unspecified role unspecified role unspecified role unspecified role association association false false false Supp Fig 2G, 4C actr5-ies6 1455560 n/a 1455581 unspecified role unspecified role unspecified role unspecified role n/a 1455569 unspecified role unspecified role unspecified role unspecified role region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false Supp. fig. 2H, 4C ino80-act1-3 1455561 n/a 1455576 unspecified role unspecified role neutral component neutral component n/a 1455575 unspecified role unspecified role neutral component neutral component n/a 1455572 unspecified role unspecified role neutral component neutral component n/a 1455571 unspecified role unspecified role neutral component neutral component n/a 1455573 unspecified role unspecified role neutral component neutral component n/a 1455574 unspecified role unspecified role neutral component neutral component n/a 1455570 unspecified role unspecified role neutral component neutral component n/a 1455566 unspecified role unspecified role neutral component neutral component n/a 1455567 unspecified role unspecified role neutral component neutral component n/a 1455578 unspecified role unspecified role neutral component neutral component n/a 1455579 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false n/a 1455569 unspecified role unspecified role neutral component neutral component n/a 1455580 unspecified role unspecified role neutral component neutral component n/a 1455568 unspecified role unspecified role neutral component neutral component n/a 1455577 unspecified role unspecified role neutral component neutral component physical association physical association false false false Fig. 1, 5A, Supp.Fig. 1 D-I DID-tag on Arp4 protrudes out at the foot of INO80. The DID-tag on Nhp10 protrudes out at the body of INO80. The DID-tag of Ies6 and Ies2 protrude at the neck of INO80. ino80-act1-4 1455562 n/a 1455566 unspecified role unspecified role neutral component neutral component lys-315 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-328 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-326 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455570 unspecified role unspecified role neutral component neutral component lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-134 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-295 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-174 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-174 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-66 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-177 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-290 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-454 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-454 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-174 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-290 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-290 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-432 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-450 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455567 unspecified role unspecified role neutral component neutral component lys-154 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-157 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-181 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-231 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-281 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-414 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-59 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-338 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-157 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-154 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-183 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-281 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-123 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-157 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-233 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-183 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-198 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-338 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-357 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455577 unspecified role unspecified role neutral component neutral component lys-688 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-688 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-202 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-211 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-775 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-158 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-158 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-165 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-165 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-165 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-396 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-158 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-165 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-172 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-172 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-132 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455578 unspecified role unspecified role neutral component neutral component lys-178 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-137 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-160 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-32 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-87 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-87 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-14 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-74 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-109 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-35 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-192 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455576 unspecified role unspecified role neutral component neutral component lys-731 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-731 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-751 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-467 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-751 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-445 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455580 unspecified role unspecified role neutral component neutral component lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-161 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-166 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-166 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455568 unspecified role unspecified role neutral component neutral component lys-248 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-261 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-267 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-286 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-286 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-250 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-232 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-250 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-261 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-286 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-286 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-53 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-295 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455575 unspecified role unspecified role neutral component neutral component lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455569 unspecified role unspecified role neutral component neutral component lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-55 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-80 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-97 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-114 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455579 unspecified role unspecified role neutral component neutral component c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false lys-1082 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1082 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-370 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-424 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-483 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-794 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-478 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-456 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-505 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-545 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1312 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1350 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-24 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-460 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-108 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-119 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-119 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-798 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-803 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1009 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-483 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-487 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-962 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1350 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1082 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1150 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1303 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-478 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-460 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-467 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-460 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-483 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-460 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-523 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-798 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1312 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-505 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1009 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1009 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1009 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1082 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455574 unspecified role unspecified role neutral component neutral component lys-210 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-218 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-313 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-343 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-473 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-313 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-313 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455573 unspecified role unspecified role neutral component neutral component lys-182 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-182 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-39 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-182 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-182 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-34 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455572 unspecified role unspecified role neutral component neutral component lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-89 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-84 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-51 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-89 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-51 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-57 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-89 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-93 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-94 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false n/a 1455571 unspecified role unspecified role neutral component neutral component lys-598 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-609 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-609 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-674 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-690 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-609 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-580 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-609 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false 1455723 1455706 1455724 1455715 1455725 1455716 1455730 1455700 1455731 1455708 1455734 1455707 1455735 1455714 1455736 1455709 1455737 1455710 1455739 1455696 1455740 1455695 1455794 1455768 1455800 1455701 1455801 1455702 1455802 1455711 1455803 1455726 1455804 1455727 1455811 1455732 1455813 1455703 1455815 1455776 1455816 1455770 1455817 1455780 1455819 1455719 1455820 1455782 1455821 1455783 1455822 1455718 1455823 1455784 1455824 1455786 1455825 1455728 1455828 1455720 1455829 1455733 1455830 1455790 1455833 1455787 1455834 1455755 1455835 1455756 1455836 1455745 1455837 1455747 1455838 1455798 1455839 1455799 1455840 1455809 1455843 1455743 1455844 1455744 1455845 1455746 1455848 1455805 1455849 1455796 1455850 1455797 1455851 1455807 1455852 1455808 1455856 1455698 1455857 1455705 1455858 1455721 1455859 1455729 1455860 1455722 1455864 1455785 1455865 1455751 1455866 1455752 1455867 1455767 1455868 1455753 1455869 1455754 1455870 1455748 1455871 1455806 1455872 1455810 1455877 1455712 1455878 1455699 1455879 1455704 1455880 1455713 1455881 1455789 1455883 1455694 1455884 1455749 1455887 1455863 1455888 1455793 1455889 1455760 1455890 1455741 1455891 1455750 1455893 1455861 1455894 1455862 1455897 1455831 1455898 1455832 1455899 1455792 1455900 1455791 1455903 1455841 1455904 1455774 1455905 1455775 1455906 1455779 1455907 1455812 1455909 1455885 1455910 1455896 1455911 1455886 1455912 1455765 1455913 1455758 1455914 1455853 1455915 1455892 1455916 1455854 1455917 1455761 1455918 1455763 1455919 1455764 1455920 1455759 1455921 1455895 1455922 1455762 1455923 1455757 1455924 1455766 1455925 1455742 1455926 1455873 1455927 1455874 1455928 1455875 1455929 1455876 1455930 1455842 1455931 1455855 1455933 1455846 1455934 1455778 1455935 1455771 1455936 1455773 1455937 1455902 1455938 1455847 1455939 1455777 1455940 1455772 physical association physical association false false false Fig. 2, Supp. Table 2 nhp10-ies3-2 1455563 n/a 1455579 unspecified role unspecified role prey prey region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false n/a 1455573 unspecified role unspecified role prey prey n/a 1455578 unspecified role unspecified role bait bait region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1455575 unspecified role unspecified role prey prey association association false false false Supp. fig. 2E nhp10-ies1-2 1455564 n/a 1455571 unspecified role unspecified role prey prey region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1455578 unspecified role unspecified role bait bait region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Supp. Fig. 2F, 4C act1-arp4-19 1455565 n/a 1455580 unspecified role unspecified role neutral component neutral component lys-166 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-161 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-166 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455566 unspecified role unspecified role neutral component neutral component lys-213 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-213 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455573 unspecified role unspecified role neutral component neutral component lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-182 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455579 unspecified role unspecified role neutral component neutral component lys-198 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-393 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-572 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-962 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-28 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-460 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-487 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false c-terminal flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range false lys-443 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-1082 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455577 unspecified role unspecified role neutral component neutral component lys-772 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455578 unspecified role unspecified role neutral component neutral component lys-85 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455574 unspecified role unspecified role neutral component neutral component lys-227 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-218 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455567 unspecified role unspecified role neutral component neutral component lys-298 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-198 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-89 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-357 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-198 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-154 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-233 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-233 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455572 unspecified role unspecified role neutral component neutral component lys-89 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455569 unspecified role unspecified role neutral component neutral component lys-55 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-61 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-54 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455575 unspecified role unspecified role neutral component neutral component lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-26 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455571 unspecified role unspecified role neutral component neutral component lys-674 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455576 unspecified role unspecified role neutral component neutral component lys-489 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-315 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455568 unspecified role unspecified role neutral component neutral component lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-261 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-261 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-232 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-232 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455570 unspecified role unspecified role neutral component neutral component lys-290 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-290 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-66 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false yeast Saccharomyces cerevisiae Baker's yeast n/a 1455582 unspecified role unspecified role neutral component neutral component lys-28 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-24 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-19 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-65 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-10 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-28 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-5 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) n/a 1455583 unspecified role unspecified role neutral component neutral component lys-13 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-9 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-9 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-32 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-45 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-9 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-60 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-45 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) n/a 1455584 unspecified role unspecified role neutral component neutral component lys-18 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-18 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-18 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-118 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-106 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-8 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-106 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-118 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-118 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-55 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-118 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-18 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-11 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-12 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-12 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-12 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) n/a 1455585 unspecified role unspecified role neutral component neutral component lys-75 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-75 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-13 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-15 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-11 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-9 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-9 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-122 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-122 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-122 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) 1456023 1455987 1456024 1456018 1456025 1455986 1456026 1455997 1456027 1455983 1456028 1455984 1456029 1456006 1456030 1456014 1456031 1455979 1456032 1456000 1456033 1455977 1456034 1455993 1456036 1455995 1456037 1455988 1456038 1455967 1456039 1455968 1456040 1455981 1456041 1455998 1456042 1456011 1456043 1455964 1456044 1455989 1456045 1456016 1456047 1456013 1456048 1455971 1456049 1455972 1456050 1455973 1456051 1456021 1456052 1456009 1456053 1455961 1456054 1456008 1456055 1455965 1456056 1456003 1456057 1455999 1456058 1455976 1456059 1455990 1456060 1456015 1456061 1455975 1456062 1455956 1456063 1455958 1456064 1455959 1456065 1455957 1456067 1455969 1456068 1455970 1456069 1456019 1456070 1455962 1456071 1456002 1456072 1456012 1456073 1456004 1456074 1456020 1456075 1455991 1456076 1455992 1456077 1455955 physical association physical association false false false Supp. Fig.5, Supp. Table 6