UniProt UniProt http://www.uniprot.org chinnakannan-2013-3 Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk PLoS ONE 2013 mimix curation chinnakannan-2013-1 Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. chlae-vero Chlorocebus (Cercopithecus) aethiops kidney cells Grivet vero Chlorocebus (Cercopithecus) aethiops kidney cells similar to cos-7 cells but these are not trasnformed anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk PLoS ONE 2013 mimix curation chinnakannan-2013-2 Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways. chlae-vero Chlorocebus (Cercopithecus) aethiops kidney cells Grivet vero Chlorocebus (Cercopithecus) aethiops kidney cells similar to cos-7 cells but these are not trasnformed anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Chinnakannan S.K., Nanda S.K., Baron M.D. Origin of viral sequences has been communicated by the authors or aa seq has been submitted (MD Baron). michael.baron@pirbright.ac.uk PLoS ONE 2013 mimix curation v_rindsa Non-structural protein V protein protein rind-sa Rinderpest virus (strain Sa) (RDV) MAEEQAYHVNKGLECIKALRARPLDSQVVEEALAAWVETSEGQTLDRMSPDEAEADYQDIGKPCFSATGPGKSSKSRSHDQEPGESNICDGELGALMDDTPMHNTEIQRYHVYDHSGEKVEGVEDADSILVQSGADDGVEFWGGDEESENSDVDPGELDPEGNAPADWRSSPIPPTTRASDVETVEGDEIQKLLEDQSRARKMTKAGKTLVVPPIPSHERSIASEKPIKKGHRREISLIWNDDRVFIDRWCNPTCSKVTVGTVRAKCICGECPRVCEQCFADPGIENRIWYHSLADVPE personal communication and submission, Dr MD Baron michael.baron@pirbright.ac.uk tyk2_human Non-receptor tyrosine-protein kinase TYK2 TYK2 protein protein human Homo sapiens Human MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC jak1_human Tyrosine-protein kinase JAK1 JAK1 JAK1A JAK1B Janus kinase 1 protein protein human Homo sapiens Human MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK v_rindr Non-structural protein V P/V protein protein rindr Rinderpest virus (strain RBOK) MAEEQAYHVNKGLECIKALRARPLDPLVVEEALAAWVETSEGQTLDRMSSDEAEADHQDISKPCFPAAGPGKSSMSRCHDQGLRGSNSCDEELGAFIGDSSMHSTEVQHYHVYDHSGEKVEGVEDADSILVQSGADDGVEVWGGDEESENSDVDSGEPDPEGSAPADWGSSPISPATRASDVETVEGDEIQKLLEDQSRIRKMTKAGKTLVVPPIPSQERPTASEKPIKKGHRREIDLIWNDGRVFIDRWCNPTCSKVTVGTVRAKCICGECPRVCEQCITDSGIENRIWYHNLADIPE proteinv_measd Non-structural protein V protein protein measd Measles virus (strain Dublin) (MeV) MAEEQARHVKNGLECIRALKAEPIDSLAVEEAMAAWSEISDNPGQDRATCKEGKAGSSGLSKPCLSAIGSTEGGAPRIRGQGSGESDDDAETLGIPSRNLQASSTGLQCYHVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDDESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGREIHELLRLQSRGNNFPKIGKTLNVPPPPNPDRASTSETPIKKGHRREISLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE proteinv_cdvo Non-structural protein V protein protein cdvo Canine distemper virus (strain Onderstepoort) (CDV) MAEEQAYHVSKGLECLKALRENPPDIEEIQEVSSLRDQTCNPGQENGTTGMQEEEDSQNLDESHEPTKGSNYVGHVPQNNPGCGERNTALVEAERPPREDIQPGPGIRCDHVYDHSGEEVKGIEDADSLVVPAGTVGNRGFERGEGSLDDSTEDSGEDYSEGNASSNWGYSFGLKPDRAADVSMLMEEELSALLRTSRNVGIQKRDGKTLQFPHNPEGKTRDPECGSIKKGHRREVSLTWNGDSCWIDKWCNPICTQVNWGIIRAKCFCGECPPTCNECKDDPEMQTRVWHATPSQDLK personal communication, submitted by MD Baron, michael.baron@pirbright.ac.uk b8pzp6_9mono P/V/C P protein protein measd Measles virus (strain Dublin) (MeV) MAEEQARHVKNGLECIRALKAEPIGSLAIEEAMAAWSEISDNPGQERATCREEKAGSSGLSKPCLSAIGSTEGGAPRIRGQGPGESDDDAETLGIPPRNLQASSTGLQCYYVYDHSGEAVKGIQDADSIMVQSGLDGDSTLSGGDNESENSDVDIGEPDTEGYAITDRGSAPISMGFRASDVETAEGGEIHELLRLQSRGNNFPKLGKTLNVPPPPDPGRASTSGTPIKKGHRREISLIWNGDRVFIDRWCNPMCSKVTLGTIRARCTCGECPRVCEQCRTDTGVDTRIWYHNLPEIPE q5zer6_pprv V protein protein Peste-des-petits-ruminants virus Peste-des-petits-ruminants virus MAEEQAYHVNKGLECIKSLKASPPDLSTIRDTIESWREGLSPSGRATPNPDTSEGDHQSINQSCSPAIGPNKVYLSPGDNLGFREITGNDCEAGLGGVQGKRSNSQVQRYYVYSHGGEEIEGLEDADSLVVQADPPVANVFNGGEDGSDDSDVDSGPDDPSRDTLYDRGSVAGNDVARSTDVEKLEGADIQEVLNSQKGKGGRFQGGKTLRVPEIPDVKHSRPSAQSIKKGTDGNSVSSGTVTECLSISGATQAVPESRWESSEQNASVGSVLKSARSAETIQGLTQESGTIASLTQP q6tv27_9mono protein protein canine distemper virus Canine distemper virus MAEEQAYHVSKGLECLKALRENPPDLEEIQEVSSIRDQTRNPGQENGTASMQEEEVSQDLDESHEPAKGSNYVGHVLQNNPGSGKGNTALVEAEQPAKDVIQPGPGIRCYHVYDHSGEEVKGTEDADSLVVPAGAVSNRGFERGEGSLDDSTEDSGEDYSEGNASSNWGYSFGLKPDRAADVSMLMEEELSALLKTSRNVGIQKRDGKTLQFPHNPEGKTGDPECGSIKKGHRREVSLTWNGDSCWIDKWCNPICTQVNWGIIRAKCVCGECPPTCSECKDDPEMQTRVWYATPSQDLK q4r4g0_chlae Signal transducer and activator of transcription STAT2 protein protein chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAVLGNDDSKATMLFFHFLDQLNYECGRCSQDPDSLLLQHNLRKFCRDIQAFSQGPTQLAEMIFNLLLEEKRILIQAQRAQPEQGEPALVTPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFSFRYKIQAKGKTPSLDSHQTKEQQILQETLNELDKRRKEVLDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLEKWFTAGAKLLFHLRQLLKELKGLSCLVSYQDDPLIKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGVTEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSLLGPALSWQFSSYVGRGLNSDQLSMLRNKLFGQNCRTEDPLLSWADFTKRESPPGKLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTISGTFLLRFSESSEGGITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLQERRKYLKHRLIVVSNRQVDELQQPLELKLEPELESLELELGLAPEPELSLDLEPLLKAGLDLGPELESVLESTLEPVMEPTLCMVSQTVPEPDRGPVSQPVPEPDLPCDLRHLNTEPMEIFRNCVKIEEIMPNGDPLLAGQNTVDEAYVSRPSHFYTDGPLMPSDF q4r4g2_chlae Signal transducer and activator of transcription STAT1 alpha protein protein chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYNCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLNPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPYFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKFLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNAV v-tyk2-1 1383229 n/a 1383232 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9B v-jak1 1383229 n/a 1383232 unspecified role unspecified role bait bait n/a 1383234 unspecified role unspecified role prey prey physical association physical association false false false 9C p_v-jak1 1383229 n/a 1383234 unspecified role unspecified role prey prey n/a 1383235 unspecified role unspecified role bait bait physical association physical association false false false 9C p_v-tyk2-1 1383229 n/a 1383233 unspecified role unspecified role prey prey n/a 1383235 unspecified role unspecified role bait bait physical association physical association false false false 9B tyk2-protein 1383229 n/a 1383236 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9B protein-jak1 1383229 n/a 1383236 unspecified role unspecified role bait bait n/a 1383234 unspecified role unspecified role prey prey physical association physical association false false false 9C protein_v-tyk2 1383229 n/a 1383237 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9B protein_v-jak1 1383229 n/a 1383237 unspecified role unspecified role bait bait n/a 1383234 unspecified role unspecified role prey prey physical association physical association false false false 9C p-p_v-1 1383229 n/a 1383238 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9B p-p_v-2 1383229 n/a 1383234 unspecified role unspecified role prey prey n/a 1383238 unspecified role unspecified role bait bait physical association physical association false false false 9C v-tyk2-2 1383229 n/a 1383239 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9B v-jak1-2 1383229 n/a 1383234 unspecified role unspecified role prey prey n/a 1383239 unspecified role unspecified role bait bait physical association physical association false false false 9C q6tv27-jak1 1383229 n/a 1383240 unspecified role unspecified role bait bait n/a 1383234 unspecified role unspecified role prey prey physical association physical association false false false 9C q6tv27-tyk2 1383229 n/a 1383233 unspecified role unspecified role prey prey n/a 1383240 unspecified role unspecified role bait bait physical association physical association false false false 9B v-stat1_alpha-1 1383230 n/a 1383232 unspecified role unspecified role bait bait n/a 1383241 unspecified role unspecified role prey prey n/a 1383242 unspecified role unspecified role prey prey association association false false false 5 p_v-stat1_alpha 1383230 n/a 1383242 unspecified role unspecified role prey prey n/a 1383241 unspecified role unspecified role prey prey n/a 1383235 unspecified role unspecified role bait bait association association false false false 5 protein-stat1_alpha 1383230 n/a 1383236 unspecified role unspecified role bait bait n/a 1383241 unspecified role unspecified role prey prey n/a 1383242 unspecified role unspecified role prey prey association association false false false 5 Weak association p-p_v 1383230 n/a 1383238 unspecified role unspecified role bait bait n/a 1383242 unspecified role unspecified role prey prey n/a 1383241 unspecified role unspecified role prey prey association association false false false 5 Weak association. v-stat1_alpha-2 1383230 n/a 1383239 unspecified role unspecified role bait bait n/a 1383241 unspecified role unspecified role prey prey n/a 1383242 unspecified role unspecified role prey prey association association false false false 5 q6tv27-stat1_alpha 1383230 n/a 1383242 unspecified role unspecified role prey prey n/a 1383241 unspecified role unspecified role prey prey n/a 1383240 unspecified role unspecified role bait bait association association false false false 5 Weak association protein_v-stat1_alph 1383230 n/a 1383237 unspecified role unspecified role bait bait n/a 1383241 unspecified role unspecified role prey prey n/a 1383242 unspecified role unspecified role prey prey association association false false false 5 Weak association. tyk2-v 1383231 n/a 1383232 unspecified role unspecified role prey prey n/a 1383233 unspecified role unspecified role bait bait physical association physical association false false false 9A v-tyk2 1383231 n/a 1383232 unspecified role unspecified role bait bait n/a 1383233 unspecified role unspecified role prey prey physical association physical association false false false 9A v-jak1-1 1383231 n/a 1383232 unspecified role unspecified role bait bait n/a 1383234 unspecified role unspecified role prey prey physical association physical association false false false 9A jak1-jak2 1383231 n/a 1383232 unspecified role unspecified role prey prey n/a 1383234 unspecified role unspecified role bait bait physical association physical association false false false 9A