<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2013-08-02+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="1427022">
                <names>
                    <shortLabel>kaitu_u_lino-2012-1</shortLabel>
                    <fullName>MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="22296769" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6897065" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-20969" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-syncytiotrophoblast</shortLabel>
                            <fullName>Human Syncytiotrophoblast</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>syncytiotrophoblast</shortLabel>
                                <fullName>Syncytiotrophoblast-fetal layer in the placenta- the interface with maternal tissue</fullName>
                            </names>
                            <xref>
                                <primaryRef db="brenda" dbAc="MI:0864" id="BTO:0001335" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="IA:2398" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6897049" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </tissue>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>pla</shortLabel>
                        <fullName>proximity ligation assay</fullName>
                        <alias typeAc="MI:0303" type="go synonym">pELISA</alias>
                        <alias typeAc="MI:1041" type="synonym">pELISA</alias>
                        <alias typeAc="MI:1041" type="synonym">PLA</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0813" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="15155907" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1218403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id=":17072308" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>antibody detection</shortLabel>
                        <fullName>identification by antibody</fullName>
                        <alias typeAc="MI:1041" type="synonym">antibody detection</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0421" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608791" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Kaitu'u-Lino T.J., Palmer K.R., Whitehead C.L., Williams E., Lappas M., Tong S.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Affinomics - Interactions curated for the Affinomics consortium.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">stong@unimelb.edu.au</attribute>
                    <attribute name="journal" nameAc="MI:0885">Am. J. Pathol. (0002-9440)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2012</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="1427023">
                <names>
                    <shortLabel>mmp14_human</shortLabel>
                    <fullName>Matrix metalloproteinase-14</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Membrane-type matrix metalloproteinase 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Membrane-type-1 matrix metalloproteinase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MMP-X1</alias>
                    <alias typeAc="MI:0301" type="gene name">MMP14</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P50281" version="SP_79" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070006" secondary="metalloaminopeptidase activity" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033739" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001501" secondary="skeletal system development" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3X23" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022617" secondary="extracellular matrix disassembly" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043627" secondary="response to estrogen" version="SP_218"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1592389" version="SP_218"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q92678" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004222" secondary="metalloendopeptidase activity" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036365" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048701" secondary="embryonic cranial skeleton morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004252" secondary="serine-type endopeptidase activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097094" secondary="craniofacial suture morphogenesis" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006026" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" secondary="zinc ion binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031012" secondary="extracellular matrix" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060322" secondary="head development" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036366" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BQQ" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903076" secondary="regulation of protein localization to plasma membrane" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021158" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006508" secondary="proteolysis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030198" secondary="extracellular matrix organization" version="SP_218"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004986.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_218"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P50281" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021805" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002477" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" secondary="positive regulation of cell growth" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000585" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001818" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_218"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000311852" version="SP_218" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045746" secondary="negative regulation of Notch signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035988" secondary="chondrocyte proliferation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_218"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-992788" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030574" secondary="collagen catabolic process" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CLZ" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006979" secondary="response to oxidative stress" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045111" secondary="intermediate filament cytoskeleton" version="SP_218"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1442490" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005796" secondary="Golgi lumen" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004175" secondary="endopeptidase activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010831" secondary="positive regulation of myotube differentiation" version="SP_218"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6GSF3" version="SP_79" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5H0U" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005178" secondary="integrin binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001958" secondary="endochondral ossification" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030324" secondary="lung development" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035987" secondary="endodermal cell differentiation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014070" secondary="response to organic cyclic compound" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042470" secondary="melanosome" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3C7X" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4P3C" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001935" secondary="endothelial cell proliferation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031638" secondary="zymogen activation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043615" secondary="astrocyte cell migration" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4P3D" version="SP_218"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000308208" version="SP_218" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048771" secondary="tissue remodeling" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048870" secondary="cell motility" version="SP_218"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K5L0" version="SP_92" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" secondary="cytoplasmic vesicle" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CM1" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905523" secondary="positive regulation of macrophage migration" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051895" secondary="negative regulation of focal adhesion assembly" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010954" secondary="positive regulation of protein processing" version="SP_218"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-35111N"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018486" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016485" secondary="protein processing" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044354" secondary="macropinosome" version="SP_218"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1474228" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MA2" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR021190" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2MQS" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008584" secondary="male gonad development" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036375" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024079" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048754" secondary="branching morphogenesis of an epithelial tube" version="SP_218"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000157227" version="SP_218" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009612" secondary="response to mechanical stimulus" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045579" secondary="positive regulation of B cell differentiation" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4QXU" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990834" secondary="response to odorant" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001541" secondary="ovarian follicle development" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018487" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1BUV" version="SP_218"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV</sequence>
            </interactor>
            <interactor id="1427024">
                <names>
                    <shortLabel>egln_human</shortLabel>
                    <fullName>Endoglin</fullName>
                    <alias typeAc="MI:0301" type="gene name">ENG</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">END</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P17813" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071260" secondary="cellular response to mechanical stimulus" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017015" secondary="regulation of transforming growth factor beta receptor signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022617" secondary="extracellular matrix disassembly" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005114" secondary="type II transforming growth factor beta receptor binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016477" secondary="cell migration" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005539" secondary="glycosaminoglycan binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031960" secondary="response to corticosteroid" version="SP_218"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2834630" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000362299" version="SP_218" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000373203" version="SP_218" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001569" secondary="branching involved in blood vessel morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060394" secondary="negative regulation of pathway-restricted SMAD protein phosphorylation" version="SP_218"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5T9C0" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905007" secondary="positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001570" secondary="vasculogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072563" secondary="endothelial microparticle" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001666" secondary="response to hypoxia" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HZW" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" secondary="transmembrane signaling receptor activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001947" secondary="heart looping" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" secondary="external side of plasma membrane" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001837" secondary="epithelial to mesenchymal transition" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070483" secondary="detection of hypoxia" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905222" secondary="atrioventricular canal morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050431" secondary="transforming growth factor beta binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005534" secondary="galactose binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003222" secondary="ventricular trabecula myocardium morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022009" secondary="central nervous system vasculogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043235" secondary="receptor complex" version="SP_218"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000109.1"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001265067.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14248" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001937" secondary="negative regulation of endothelial cell proliferation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010629" secondary="negative regulation of gene expression" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" secondary="positive regulation of angiogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" secondary="cell surface" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030155" secondary="regulation of cell adhesion" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070278" secondary="extracellular matrix constituent secretion" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055009" secondary="atrial cardiac muscle tissue morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010862" secondary="positive regulation of pathway-restricted SMAD protein phosphorylation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032967" secondary="positive regulation of collagen biosynthetic process" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003208" secondary="cardiac ventricle morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042325" secondary="regulation of phosphorylation" version="SP_218"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001108225.1"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P17813" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003209" secondary="cardiac atrium morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051897" secondary="positive regulation of protein kinase B signaling" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016604" secondary="nuclear body" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030509" secondary="BMP signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060326" secondary="cell chemotaxis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048745" secondary="smooth muscle tissue development" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003273" secondary="cell migration involved in endocardial cushion formation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042060" secondary="wound healing" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003084" secondary="positive regulation of systemic arterial blood pressure" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048845" secondary="venous blood vessel morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048870" secondary="cell motility" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048844" secondary="artery morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035912" secondary="dorsal aorta morphogenesis" version="SP_218"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-6246N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031953" secondary="negative regulation of protein autophosphorylation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" secondary="regulation of transcription, DNA-templated" version="SP_218"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000106991" version="SP_218" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003198" secondary="epithelial to mesenchymal transition involved in endocardial cushion formation" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5HZV" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034713" secondary="type I transforming growth factor beta receptor binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" secondary="regulation of cell population proliferation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030513" secondary="positive regulation of BMP signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048185" secondary="activin binding" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097084" secondary="vascular associated smooth muscle cell development" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003148" secondary="outflow tract septum morphogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905065" secondary="positive regulation of vascular associated smooth muscle cell differentiation" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060348" secondary="bone development" version="SP_218"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001507" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030336" secondary="negative regulation of cell migration" version="SP_218"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5I04" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" secondary="cell adhesion" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030512" secondary="negative regulation of transforming growth factor beta receptor signaling pathway" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015026" secondary="coreceptor activity" version="SP_218"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14926" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005024" secondary="transforming growth factor beta-activated receptor activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051001" secondary="negative regulation of nitric-oxide synthase activity" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_218"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003203" secondary="endocardial cushion morphogenesis" version="SP_218"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDRGTLPLAVALLLASCSLSPTSLAETVHCDLQPVGPERGEVTYTTSQVSKGCVAQAPNAILEVHVLFLEFPTGPSQLELTLQASKQNGTWPREVLLVLSVNSSVFLHLQALGIPLHLAYNSSLVTFQEPPGVNTTELPSFPKTQILEWAAERGPITSAAELNDPQSILLRLGQAQGSLSFCMLEASQDMGRTLEWRPRTPALVRGCHLEGVAGHKEAHILRVLPGHSAGPRTVTVKVELSCAPGDLDAVLILQGPPYVSWLIDANHNMQIWTTGEYSFKIFPEKNIRGFKLPDTPQGLLGEARMLNASIVASFVELPLASIVSLHASSCGGRLQTSPAPIQTTPPKDTCSPELLMSLIQTKCADDAMTLVLKKELVAHLKCTITGLTFWDPSCEAEDRGDKFVLRSAYSSCGMQVSASMISNEAVVNILSSSSPQRKKVHCLNMDSLSFQLGLYLSPHFLQASNTIEPGQQSFVQVRVSPSVSEFLLQLDSCHLDLGPEGGTVELIQGRAAKGNCVSLLSPSPEGDPRFSFLLHFYTVPIPKTGTLSCTVALRPKTGSQDQEVHRTVFMRLNIISPDLSGCTSKGLVLPAVLGITFGAFLIGALLTAALWYIYSHTRSPSKREPVVAVAAPASSESSSTNHSIGSTQSTPCSTSSMA</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-20969-1" id="1427025">
                <names>
                    <shortLabel>eng-mmp14</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-6897099" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-20969-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1427022</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1427026">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6897101" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1427023</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1427027">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-6897102" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1427024</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>proximity</shortLabel>
                        <fullName>proximity</fullName>
                        <alias typeAc="MI:1041" type="synonym">close-contact colocalization</alias>
                        <alias typeAc="MI:1041" type="synonym">neighbourhood interaction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">2 G/H</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
