MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint cohen-2012-2 Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. in vitro In vitro crosslink cross-linking study crosslink predetermined predetermined participant predetermined Cohen TJ., Hwang AW., Unger T., Trojanowski JQ., Lee VM. EMBO J. (0261-4189) 2012 Only protein-protein interactions imex curation cohen-2012-1 Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 fluorescence imaging fluorescence microscopy fluorescence imaging predetermined predetermined participant predetermined Cohen TJ., Hwang AW., Unger T., Trojanowski JQ., Lee VM. EMBO J. (0261-4189) 2012 Only protein-protein interactions imex curation cohen-2012-3 Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. human-qbi-293 Homo sapiens qbi-293 qbi-293 crosslink cross-linking study crosslink predetermined predetermined participant predetermined Cohen TJ., Hwang AW., Unger T., Trojanowski JQ., Lee VM. EMBO J. (0261-4189) 2012 Only protein-protein interactions imex curation tadbp_human TAR DNA-binding protein 43 TARDBP TDP43 protein protein human Homo sapiens Human MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM tiar_human Nucleolysin TIAR TIAL1 TIA-1-related protein protein protein human Homo sapiens Human MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ tardbp-tardbp 1306906 tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified Q13148:p.Cys198Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys175Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys173Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys244Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified Q13148:p.Cys173Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys175Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys198Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Q13148:p.Cys244Ser mutation disrupting interaction mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false homomint mint f3b f3c f6b tardbp-tardbp-1 1306906 tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified disulfide bond disulfide bond disulfide bridge SS-bond false false false homomint mint f5a sf3 tardbp-1 1306906 tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified Q13148:p.Gly348Cys mutation disrupting interaction mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 direct interaction direct interaction false false false mint f8a f8b tardbp-1 1306906 tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role neutral component neutral component purified purified Q13148:p.Ser379Cys mutation disrupting interaction mutation increasing mutation increasing interaction mutation increasing mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 2.0 direct interaction direct interaction false false false mint f8a f8b tardbp-tial1 1306907 tadbp_human TDP43 1306909 immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell tiar_human TIAR 1306910 immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell colocalization colocalization false false false f1a homomint mint tardbp-tardbp-2 1306908 tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell tadbp_human TDP43 1306909 western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey over-expressed over expressed level over-expressed living cell living cell disulfide bond disulfide bond disulfide bridge SS-bond false false false homomint mint f5b sf3