I2D I2D bakthavatchalu-2012-1 Manganese superoxide dismutase is a mitochondrial fidelity protein that protects Polγ against UV-induced inactivation. mouse-skin Mus musculus skin cells skin anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Bakthavatchalu V., Dey S., Xu Y., Noel T., Jungsuwadee P., Holley A.K., Dhar S.K., Batinic-Haberle I., St Clair D.K. Cancer - Interactions investigated in the context of cancer Skin mitochondrial lysates from wild type C57BL/6 mice were exposed to 5kJ/m2 of UVB radiation for 1 or 24hours. dstc100@uky.edu dstcl00@uky.edu Oncogene (0950-9232) 2012 Only protein-protein interactions imex curation Curated by: I2D - Interologous Interaction Database sodm_mouse Superoxide dismutase [Mn], mitochondrial Sod2 Sod-2 protein protein mouse Mus musculus Mouse MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFWTNLSPKGGGEPKGELLEAIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYTACKK p53_mouse Cellular tumor antigen p53 Tp53 P53 Trp53 Tumor suppressor p53 protein protein mouse Mus musculus Mouse MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD dpog1_mouse DNA polymerase subunit gamma-1 Mitochondrial DNA polymerase catalytic subunit PolG-alpha Polg Polg1 protein protein mouse Mus musculus Mouse MSRLLWKKVAGAKVASGPVPATARWVASSVLDPVPSDGRPPSQMPSSENGQLRLNPLLIQMLSRGLHEQIFGCGGEMPDEAAVQRSVEHLQKHGLWGQPATPLPDVELRLPRLFGGNLDQHFRLLAQKQSLPYLEAAASLLEAQLPPEPKSWAWAEGWTRYGPEGEAEPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSRRLVEERYSWTSQLSPADLIPLGGSTSASSSTKQDGQEQLVVGHNVSFDRAHIREQYLIQDSRMRFLDTMSMHMAISGLSSFQRSLWMGAKQGKHKNPAAHKARAEVPEESQWSSESSSWDWMDISSANNLADVHNLYVGGPPLEKEPRELFVKGSMRDIRENFQDLMQYCARDVWATFEVFQQQLPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLTEAQNTYEELQREMKKSLMDLANDACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKPASASKLPIEGAGPFGDPMDQEDPGPPSEEEELQRSVTAHNRLQQLRSTTDLLPKRPQHLPGHPGWYRQLCPRLDDPAWAPGPSLLSLQMRVTPKLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTEPPVSPTVESAAVTCPYRAIESLYRKHCLEQGKQQLEPQEVDLAEEFLLTDNSAMWQTVEELGCLDVEAEAKMENSGLSQPLVLPAACAPKSSQPTYHHGNGPYNDVNIPGCWFFKLPHKDGNNYNVGSPFAKDFLPKMEDGTLQAGPGGASGPRALEINKMISFWRNAHKRISSQMVVWLPRSALPRVVTRHPAFDEEGHYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQAPPGYVLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTAATVGISREHAKIFNYGRIYGAGQSFAERLLMQFNHRLTRQEAAEKAQQMYAVTKGLRRYRLSADGEWLVKQLNLPVDRTEDGWVSLQDLRMIRREASRKSRWKKWEVAAERAWTGGTESEMFNKLESIAMSDTPRTPVLGCCISRALEPSVVQGEFITSRVNWVVQSSAVDYLHLMLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLGLNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMERRYGIPQGEALDIYQIIELTKGSLEKRSQPGP tp53-sod2 1316613 n/a 1316614 unspecified role unspecified role prey prey n/a 1316615 unspecified role unspecified role bait bait physical association physical association false false false 4a sod2-tp53 1316613 n/a 1316614 unspecified role unspecified role bait bait n/a 1316615 unspecified role unspecified role prey prey physical association physical association false false false 4a polg-sod2 1316613 n/a 1316616 unspecified role unspecified role bait bait n/a 1316614 unspecified role unspecified role prey prey physical association physical association false false false 4b, c MnSOD and PolG interact in both p53 WT and KO mice. sod2-polg 1316613 n/a 1316614 unspecified role unspecified role bait bait n/a 1316616 unspecified role unspecified role prey prey physical association physical association false false false 4b, c MnSOD and PolG interact in both p53 WT and KO mice. tp53-polg 1316613 n/a 1316616 unspecified role unspecified role prey prey n/a 1316615 unspecified role unspecified role bait bait physical association physical association false false false 3a polg-tp53 1316613 n/a 1316616 unspecified role unspecified role bait bait n/a 1316615 unspecified role unspecified role prey prey physical association physical association false false false 3a