NTNU NTNU, Norwegian University of Science and Technology www.ntnu.no/home chen-2011e-1 c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells. human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Chen Y., Xu J., Borowicz S., Collins C., Huo D., Olopade O.I. folopade@bsd.uchicago.edu BMC Cancer 2011 imex curation chen-2011e-2 c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells. human-mda_mb_231 Homo sapiens Caucasian breast adenocarcinoma mda_mb_231 Human Caucasian breast adenocarcinoma ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Chen Y., Xu J., Borowicz S., Collins C., Huo D., Olopade O.I. folopade@bsd.uchicago.edu BMC Cancer 2011 imex curation brca1_human_gene breast cancer 1, early onset gene gene human Homo sapiens Human myc_human Myc proto-oncogene protein BHLHE39 Transcription factor p64 MYC Proto-oncogene c-Myc Class E basic helix-loop-helix protein 39 protein protein human Homo sapiens Human MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGDNDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAGGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA myc-brca1 1295249 n/a 1295251 unspecified role unspecified role prey prey e-box x region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false e-box y region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells n/a c-Myc 1295252 unspecified role unspecified role bait bait human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells association association false false false Figure 4A Target gene BRCA1 regulatory regions assessed in the ChIP-experiments: E box X: -912 to -907 E box Y: -1292 to -1286 myc-brca1-1 1295250 n/a 1295251 unspecified role unspecified role prey prey e box y binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false e box x binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1295252 unspecified role unspecified role bait bait association association false false false Figure 4A