UniProt UniProt http://www.uniprot.org doyle-2010-4 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-1 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. human Homo sapiens Human tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-2 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-3 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. human-u2-os Human U2-OS osteosarcoma cell line u2-os U2-OS osteocaroma cell line Not in CAPRI and no primary literature reference fluorescence imaging fluorescence microscopy fluorescence imaging anti tag immunost anti tag immunostaining anti tag immunost Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-5 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-6 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column weight by comassie molecular weight estimation by coomasie staining weight by comassie Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-7 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Host cell line not given but only human cell lines used throughout. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-8 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro ubiquitinase assay ubiquitinase assay ubiquitinase assay anti tag western anti tag western blot anti tag western Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-9 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro ubiquitinase assay ubiquitinase assay ubiquitinase assay western blot western blot Immuno blot Immuno blot Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-10 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation doyle-2010-11 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Doyle J.M., Gao J., Wang J., Yang M., Potts P.R. Species origin of proteins confirmed by authors (e-mail). ryan.potts@utsouthwestern.edu Mol. Cell (1097-2765) 2010 mimix curation maga2_human Melanoma-associated antigen 2 MAGEA2 MAGEA2B MAGE2 MAGEA2A MAGE2 MAGEA2 Cancer/testis antigen 1.2 MAGE-2 antigen protein protein human Homo sapiens Human MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE tif1b_human Transcription intermediary factor 1-beta TRIM28 KAP1 RNF96 TIF1B Tripartite motif-containing protein 28 Nuclear corepressor KAP-1 KRAB-associated protein 1 KRAB-interacting protein 1 RING finger protein 96 E3 SUMO-protein ligase TRIM28 RING-type E3 ubiquitin transferase TIF1-beta protein protein human Homo sapiens Human MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGPAPMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSGLMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAGTPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTSSGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVPGEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP maga3_human Melanoma-associated antigen 3 MAGEA3 MAGE3 Antigen MZ2-D Cancer/testis antigen 1.3 MAGE-3 antigen protein protein human Homo sapiens Human MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE 3F5EB13D1C9946A1 maga6_human Melanoma-associated antigen 6 MAGE-6 antigen MAGE3B antigen Cancer/testis antigen 1.6 MAGEA6 MAGE6 protein protein human Homo sapiens Human MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE magc2_human Melanoma-associated antigen C2 MAGEC2 HCA587 MAGEE1 Cancer/testis antigen 10 Hepatocellular carcinoma-associated antigen 587 MAGE-C2 antigen MAGE-E1 antigen protein protein human Homo sapiens Human MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE magd1_human Melanoma-associated antigen D1 MAGE-D1 antigen Neurotrophin receptor-interacting MAGE homolog MAGE tumor antigen CCF MAGED1 NRAGE PRO2292 PP2250 protein protein human Homo sapiens Human MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE magbi_human Melanoma-associated antigen B18 MAGE-B18 antigen MAGEB18 protein protein human Homo sapiens Human MPRGQKSKLRAREKRHQARCENQDLGATQATVAEGESPSPAYLLFGDRPQNLPAAETPSIPEALQGAPSTTNAIAPVSCSSNEGASSQDEKSLGSSREAEGWKEDPLNKKVVSLVHFLLQKYETKEPITKGDMIKFVIRKDKCHFNEILKRASEHMELALGVDLKEVDPIRHYYAFFSKLDLTYDETTSDEEKIPKTGLLMIALGVIFLNGNRAPEEAVWEIMNMMGVYADRKHFLYGDPRKVMTKDLVQLKYLEYQQVPNSDPPRYEFLWGPRAHAETSKMKVLEFVAKIHDTVPSAFPSCYEEALRDEEQRTQARAAARAHTAAMANARSRTTSSSFSHAK lnx1_human E3 ubiquitin-protein ligase LNX LNX1 LNX Numb-binding protein 1 Ligand of Numb-protein X 1 PDZ domain-containing RING finger protein 2 PDZRN2 RING-type E3 ubiquitin transferase LNX UNQ574/PRO1136 protein protein human Homo sapiens Human MNQPESANDPEPLCAVCGQAHSLEENHFYSYPEEVDDDLICHICLQALLDPLDTPCGHTYCTLCLTNFLVEKDFCPMDRKPLVLQHCKKSSILVNKLLNKLLVTCPFREHCTQVLQRCDLEHHFQTSCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL nse1_human Non-structural maintenance of chromosomes element 1 homolog NSMCE1 HSPC333 HSPC337 protein protein human Homo sapiens Human MQGSTRRMGVMTDVHRRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYPDAVKICNICHSLLIQGQSCETCGIRMHLPCVAKYFQSNAEPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQH magf1_human Melanoma-associated antigen F1 MAGEF1 MAGE-F1 antigen protein protein human Homo sapiens Human MLQTPESRGLPVPQAEGEKDGGHDGETRAPTASQERPKEELGAGREEGAAEPALTRKGARALAAKALARRRAYRRLNRTVAELVQFLLVKDKKKSPITRSEMVKYVIGDLKILFPDIIARAAEHLRYVFGFELKQFDRKHHTYILINKLKPLEEEEEEDLGGDGPRLGLLMMILGLIYMRGNSAREAQVWEMLRRLGVQPSKYHFLFGYPKRLIMEDFVQQRYLSYRRVPHTNPPEYEFSWGPRSNLEISKMEVLGFVAKLHKKEPQHWPVQYREALADEADRARAKARAEASMRARASARAGIHLW nse3_human Non-structural maintenance of chromosomes element 3 homolog HCA4 Hepatocellular carcinoma-associated protein 4 MAGE-G1 antigen MAGEG1 Melanoma-associated antigen G1 NDNL2 Necdin-like protein 2 NSMCE3 protein protein human Homo sapiens Human MLQKPRNRGRSGGQAERDRDWSHSGNPGASRAGEDARVLRDGFAEEAPSTSRGPGGSQGSQGPSPQGARRAQAAPAVGPRSQKQLELKVSELVQFLLIKDQKKIPIKRADILKHVIGDYKDIFPDLFKRAAERLQYVFGYKLVELEPKSNTYILINTLEPVEEDAEMRGDQGTPTTGLLMIVLGLIFMKGNTIKETEAWDFLRRLGVYPTKKHLIFGDPKKLITEDFVRQRYLEYRRIPHTDPVDYEFQWGPRTNLETSKMKVLKFVAKVHNQDPKDWPAQYCEALADEENRARPQPSGPAPSS magd4_human Melanoma-associated antigen D4 MAGED4B MAGED4A MAGE-D4 antigen MAGE-E1 antigen MAGED4 KIAA1859 MAGEE1 protein protein human Homo sapiens Human MAEGSFSVQSESYSVEDMDEGSDEVGEEEMVEGNDYEEFGAFGGYGTLTSFDIHILRAFGSLGPGLRILSNEPWELENPVLAQTLVEALQLDPETLANETAARAANVARAAASNRAARAAAAAARTAFSQVVASHRVATPQVSGEDTQPTTYAAEAQGPTPEPPLASPQTSQMLVTSKMAAPEAPATSAQSQTGSPAQEAATEGPSSACAFSQAPCAREVDANRPSTAFLGQNDVFDFTQPAGVSGMAFPRPKRPAPAQEAATEGPSAASGVPQTGPGREVAATRPKTTKSGKALAKTRWVEPQNVVAAAAAKAKMATSIPEPEGAAAATAQHSAEPWARMGGKRTKKSKHLDDEYESSEEERETPAVPPTWRASQPSLTVRAQLAPRPPMAPRSQIPSRHVLCLPPRNVTLLQERANKLVKYLMIKDYKKIPIKRADMLKDVIREYDEHFPEIIERATYTLEKKFGIHLKEIDKEEHLYILVCTRDSSARLLGKTKDTPRLSLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPFLGDLRKLITDDFVKQKYLEYKKIPNSNPPEYEFLWGLRARHETSKMRVLRFIAQNQNRDPREWKAHFLEAVDDAFKTMDVDMAEEHARAQMRAQMNIGDEALIGRWSWDDIQVELLTWDEDGDFGDAWARIPFAFWARYHQYILNSNRANRRATWRAGVSSGTNGGASTSVLDGPSTSSTIRTRNAARAGASFFSWIQHR tri27_human Zinc finger protein RFP TRIM27 RNF76 RFP Ret finger protein Tripartite motif-containing protein 27 RING finger protein 76 RING-type E3 ubiquitin transferase TRIM27 protein protein human Homo sapiens Human MASGSVAECLQQETTCPVCLQYFAEPMMLDCGHNICCACLARCWGTAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPGGEMGVCEKHREPLKLYCEEDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNQLDHLKRVKDLKKRRRAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGAITQFSCNISHLSSLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEKIHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDNLRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSVCRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFYNVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHSMETSP magl2_human MAGE-like protein 2 MAGEL2 NDNL1 Necdin-like protein 1 Protein nM15 protein protein human Homo sapiens Human MSQLSKNLGDSSPPAEAPKPPVYSRPTVLMRAPPASSRAPPVPWDPPPIDLQASLAAWQAPQPAWEAPQGQLPAPVVPMTQPPALGGPIVPAPPLGGPMGKPPTPGVLMVHPPPPGAPMAQPPTPGVLMVHPSAPGAPMAHPPPPGTPMSHPPPPGTPMAHPPPPGTPMAHPPPPGTPMVHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAHPPPPGTPMAQPPAPGVLMAQPLTPGVLMVQPAAPGAPMVQPPPAAMMTQPQPSGAPMAKPPGPGVLMIHPPGARAPMTQPPASGAPMAQPAAPPAQPMAPPAQPMASWAPQAQPLILQIQSQVIRAPPQVPQGPQAPPAQLATPPGWQATSPGWQATQQGWQATPLTWQTTQVTWQAPAVTWQVPPPMRQGPPPIRPGPPPIRPGPPPVRQAPPLIRQAPPVIRQAPPVIRQAPPVIRQAPAVIRQAPPVIRQAPPVIRQAPPVIRQAPPLIRQAPPPIRPAPQVLATQPPLWQALPPPPPLRQAPQARLPAPQVQAAPQVPTAPPATQVPAAPPAGPQVPQPVLPAPLSAPLSAPQAVHCPSIIWQAPKGQPPVPHEIPTSMEFQEVQQTQALAWQAQKAPTHIWQPLPAQEAQRQAPPLVQLEQPFQGAPPSQKAVQIQLPPQQAQASGPQAEVPTLPLQPSWQAPPAVLQAQPGPPVAAANFPLGSAKSLMTPSGECRASSIDRRGSSKERRTSSKERRAPSKDRMIFAATFCAPKAVSAARAHLPAAWKNLPATPETFAPSSSVFPATSQFQPASLNAFKGPSAASETPKSLPYALQDPFACVEALPAVPWVPQPNMNASKASQAVPTFLMATAAAPQATATTQEASKTSVEPPRRSGKATRKKKHLEAQEDSRGHTLAFHDWQGPRPWENLNLSDWEVQSPIQVSGDWEHPNTPRGLSGWEGPSTSRILSGWEGPSASWALSAWEGPSTSRALGLSESPGSSLPVVVSEVASVSPGSSATQDNSKVEAQPLSPLDERANALVQFLLVKDQAKVPVQRSEMVKVILREYKDECLDIINRANNKLECAFGYQLKEIDTKNHAYIIINKLGYHTGNLVASYLDRPKFGLLMVVLSLIFMKGNCVREDLIFNFLFKLGLDVRETNGLFGNTKKLITEVFVRQKYLEYRRIPYTEPAEYEFLWGPRAFLETSKMLVLRFLAKLHKKDPQSWPFHYLEALAECEWEDTDEDEPDTGDSAHGPTSRPPPR pja1_human E3 ubiquitin-protein ligase Praja-1 RING finger protein 70 PJA1 RNF70 RING-type E3 ubiquitin transferase Praja-1 protein protein human Homo sapiens Human MGQESSKPVWPNPTGGYQSNTGRRYGRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRSPFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVRGKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVASQSSSEGKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDDDDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDFWTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPGASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFMLDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSGTCPVCRCMFPPPL nse4a_human Non-structural maintenance of chromosomes element 4 homolog A NSMCE4A C10orf86 PP4762 protein protein human Homo sapiens Human MSGDSSGRGPEGRGRGRDPHRDRTRSRSRSRSPLSPRSRRGSARERREAPERPSLEDTEPSDSGDEMMDPASLEAEADQGLCRQIRHQYRALINSVQQNREDILNAGDKLTEVLEEANTLFNEVSRAREAVLDAHFLVLASDLGKEKAKQLRSDLSSFDMLRYVETLLTHMGVNPLEAEELIRDEDSPDFEFIVYDSWKITGRTAENTFNKTHTFHFLLGSIYGECPVPKPRVDRPRKVPVIQEERAMPAQLRRMEESHQEATEKEVERILGLLQTYFREDPDTPMSFFDFVVDPHSFPRTVENIFHVSFIIRDGFARIRLDQDRLPVIEPVSINEENEGFEHNTQVRNQGIIALSYRDWEEIVKTFEISEPVITPSQRQQKPSA p53_human Cellular tumor antigen p53 TP53 P53 Tumor suppressor p53 Phosphoprotein p53 Antigen NY-CO-13 protein protein human Homo sapiens Human MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD ube2h_human Ubiquitin-conjugating enzyme E2 H UBE2H Ubiquitin-protein ligase H Ubiquitin carrier protein H UbcH2 Ubiquitin-conjugating enzyme E2-20K (E3-independent) E2 ubiquitin-conjugating enzyme H E2 ubiquitin-conjugating enzyme H protein protein human Homo sapiens Human MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL magb2_human Melanoma-associated antigen B2 MAGEB2 MAGE-B2 antigen DSS-AHC critical interval MAGE superfamily 6 MAGE XP-2 antigen Cancer/testis antigen 3.2 protein protein human Homo sapiens Human MPRGQKSKLRAREKRRKARDETRGLNVPQVTEAEEEEAPCCSSSVSGGAASSSPAAGIPQEPQRAPTTAAAAAAGVSSTKSKKGAKSHQGEKNASSSQASTSTKSPSEDPLTRKSGSLVQFLLYKYKIKKSVTKGEMLKIVGKRFREHFPEILKKASEGLSVVFGLELNKVNPNGHTYTFIDKVDLTDEESLLSSWDFPRRKLLMPLLGVIFLNGNSATEEEIWEFLNMLGVYDGEEHSVFGEPWKLITKDLVQEKYLEYKQVPSSDPPRFQFLWGPRAYAETSKMKVLEFLAKVNGTTPCAFPTHYEEALKDEEKAGV mage1_human Melanoma-associated antigen E1 MAGE-E1 antigen Hepatocellular carcinoma-associated protein 1 MAGEE1 HCA1 KIAA1587 Alpha-dystrobrevin-associated MAGE Protein protein protein human Homo sapiens Human MSLVSQNSRRRRRRVAKATAHNSSWGEMQAPNAPGLPADVPGSDVPQGPSDSQILQGLCASEGPSTSVLPTSAEGPSTFVPPTISEASSASGQPTISEGPGTSVLPTPSEGLSTSGPPTISKGLCTSVTLAASEGRNTSRPPTSSEEPSTSVPPTASEVPSTSLPPTPGEGTSTSVPPTAYEGPSTSVVPTPDEGPSTSVLPTPGEGPGTSVPLAATEGLSTSVQATPDEGPSTSVPPTATEGLSTPVPPTRDEGPSTSVPATPGEGPSTSVLPAASDGQSISLVPTRGKGSSTSVPPTATEGLSTSVQPTAGEGSSTSVPPTPGGGLSTSVPPTATEELSTSVPPTPGEGPSTSVLPIPGEGLSTSVPPTASDGSDTSVPPTPGEGASTLVQPTAPDGPGSSVLPNPGEGPSTLFSSSASVDRNPSKCSLVLPSPRVTKASVDSDSEGPKGAEGPIEFEVLRDCESPNSISIMGLNTSRVAITLKPQDPMEQNVAELLQFLLVKDQSKYPIRESEMREYIVKEYRNQFPEILRRAAAHLECIFRFELRELDPEAHTYILLNKLGPVPFEGLEESPNGPKMGLLMMILGQIFLNGNQAKEAEIWEMLWRMGVQRERRLSIFGNPKRLLSVEFVWQRYLDYRPVTDCKPVEYEFFWGPRSHLETTKMKILKFMAKIYNKDPMDWPEKYNEALEEDAARAFAEGWQALPHFRRPFFEEAAAEVPSPDSEVSSYSSKYAPHSWPESRLESKARKLVQLFLLMDSTKLPIPKKGILYYIGRECSKVFPDLLNRAARTLNHVYGTELVVLDPRNHSYTLYNRREMEETEEIVDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGVQAGRKHVITCRYLSQRYIDSLRVPDSDPVQYEFVWGPRARLETSKMKALRYVARIHRKEPQDWPQQYREAMEDEANRADVGHRQIFVHNFR necd_human Necdin NDN protein protein human Homo sapiens Human MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG uba1_human Ubiquitin-like modifier-activating enzyme 1 Ubiquitin-activating enzyme E1 Protein A1S9 UBA1 A1S9T UBE1 protein protein human Homo sapiens Human MSSSPLSKKRRVSGPDPKPGSNCSPAQSVLSEVPSVPTNGMAKNGSEADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVTAYTGPLVEDFLSGFQVVVLTNTPLEDQLRVGEFCHNRGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMVELNGNQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLVASLAEPDFVVTDFAKFSRPAQLHIGFQALHQFCAQHGRPPRPRNEEDAAELVALAQAVNARALPAVQQNNLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEVLTEDKCLQRQNRYDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEIIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNPLHLDYVMAAANLFAQTYGLTGSQDRAAVATFLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDIPSADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR magea2-trim28-3 1272902 n/a 1272913 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false S3A , 3A and Table 3B trim28-magea3 1272902 n/a 1272915 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B trim28-magea6 1272902 n/a 1272916 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B trim28-magec2 1272902 n/a 1272914 unspecified role unspecified role bait bait n/a 1272917 unspecified role unspecified role prey prey physical association physical association false false false S3A, B, 3A and Table 3B trim28-maged1 1272902 n/a 1272914 unspecified role unspecified role bait bait n/a 1272918 unspecified role unspecified role prey prey physical association physical association false false false S3A, 3A and Table 3B lnx1-mageb18-1 1272902 n/a 1272919 unspecified role unspecified role prey prey n/a 1272920 unspecified role unspecified role bait bait physical association physical association false false false S3A, B and Table 3B magef1-nsmce1 1272902 n/a 1272921 unspecified role unspecified role bait bait n/a 1272922 unspecified role unspecified role prey prey physical association physical association false false false S3A and Table 3B nsmce1-ndnl2 1272902 n/a 1272921 unspecified role unspecified role bait bait n/a 1272923 unspecified role unspecified role prey prey physical association physical association false false false S3A, B and Table 3B maged4b-trim27 1272902 n/a 1272924 unspecified role unspecified role prey prey n/a 1272925 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B trim27-magef1 1272902 n/a 1272925 unspecified role unspecified role bait bait n/a 1272922 unspecified role unspecified role prey prey physical association physical association false false false S3A and Table 3B trim27-magel2 1272902 n/a 1272926 unspecified role unspecified role prey prey n/a 1272925 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B maged1-pja1-4 1272902 n/a 1272927 unspecified role unspecified role prey prey n/a 1272918 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B ndnl2-pja1 1272902 n/a 1272927 unspecified role unspecified role prey prey n/a 1272923 unspecified role unspecified role bait bait physical association physical association false false false S3A and Table 3B ndnl2-nsmce1-7 1272902 n/a 1272923 unspecified role unspecified role bait bait n/a 1272921 unspecified role unspecified role prey prey physical association physical association false false false 5B ndnl2-nsmce4a 1272902 n/a 1272928 unspecified role unspecified role prey prey n/a 1272923 unspecified role unspecified role bait bait physical association physical association false false false 5B magec2-trim28-6 1272902 n/a 1272917 unspecified role unspecified role bait bait n/a 1272914 unspecified role unspecified role prey prey physical association physical association false false false S3I and S5E, S6G lnx1-mageb18-2 1272902 n/a 1272920 unspecified role unspecified role prey prey n/a 1272919 unspecified role unspecified role bait bait physical association physical association false false false S3K ndnl2-nsmce1-8 1272902 n/a 1272921 unspecified role unspecified role prey prey n/a 1272923 unspecified role unspecified role bait bait physical association physical association false false false S3M magec2-tp53-3 1272902 n/a 1272917 unspecified role unspecified role prey prey n/a 1272929 unspecified role unspecified role bait bait physical association physical association false false false S6F magea2-tp53-3 1272902 n/a 1272913 unspecified role unspecified role prey prey n/a 1272929 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait association association false false false S6H MAGEA2 has been detected with anti-MAGE-A antibody. magec2-tp53-4 1272902 n/a 1272929 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait n/a 1272917 unspecified role unspecified role prey prey association association false false false S6H MAGEC2 has been detected with anti-MAGE-C2 antibody. magea2-ube2h-1 1272902 n/a 1272913 unspecified role unspecified role bait bait n/a 1272930 unspecified role unspecified role prey prey physical association physical association false false false S6J magec2-ube2h 1272902 n/a 1272930 unspecified role unspecified role prey prey n/a 1272917 unspecified role unspecified role bait bait physical association physical association false false false S6J magea2-trim28 1272903 n/a 1272913 unspecified role unspecified role bait bait n/a 1272914 unspecified role unspecified role prey prey physical association physical association false false false 1 and supplement. table S1 magea3-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272915 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 magea6-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272916 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 mageb2-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272931 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 magec2-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272917 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 magee1-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272932 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 ndn-trim28 1272903 n/a 1272914 unspecified role unspecified role prey prey n/a 1272933 unspecified role unspecified role bait bait physical association physical association false false false 1 and supplement. table S1 mageb18-lnx1 1272903 n/a 1272919 unspecified role unspecified role bait bait n/a 1272920 unspecified role unspecified role prey prey physical association physical association false false false 1 and supplement. table S1 ndnl2-nsmce1-3 1272903 n/a 1272921 unspecified role unspecified role prey prey n/a 1272923 unspecified role unspecified role bait bait n/a 1272927 unspecified role unspecified role prey prey association association false false false 1 and supplement. table S1 magea2-trim28-1 1272904 n/a 1272913 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false 2A magec2-trim28-1 1272904 n/a 1272917 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false 2A and S5F magee1-trim28-1 1272904 n/a 1272914 unspecified role unspecified role bait bait n/a 1272932 unspecified role unspecified role prey prey physical association physical association false false false 2A mageb18-lnx1-1 1272904 n/a 1272919 unspecified role unspecified role prey prey n/a 1272920 unspecified role unspecified role bait bait physical association physical association false false false 2A maged1-pja1-2 1272904 n/a 1272927 unspecified role unspecified role bait bait n/a 1272918 unspecified role unspecified role prey prey physical association physical association false false false 2A ndnl2-nsmce1-9 1272904 n/a 1272921 unspecified role unspecified role bait bait n/a 1272923 unspecified role unspecified role prey prey physical association physical association false false false S5D magea2-ube2h 1272904 n/a 1272930 unspecified role unspecified role bait bait n/a 1272913 unspecified role unspecified role prey prey physical association physical association false false false S6I ube2h-magec2 1272904 n/a 1272917 unspecified role unspecified role prey prey n/a 1272930 unspecified role unspecified role bait bait physical association physical association false false false S6I magea2-trim28-4 1272905 n/a 1272914 unspecified role unspecified role neutral component neutral component n/a 1272913 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B magec2-trim28-2 1272905 n/a 1272917 unspecified role unspecified role neutral component neutral component n/a 1272914 acceptor acceptor neutral component neutral component colocalization colocalization false false false 2B ndnl2-nsmce1-4 1272905 n/a 1272923 unspecified role unspecified role neutral component neutral component n/a 1272921 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B lnx1-mageb18 1272905 n/a 1272920 unspecified role unspecified role neutral component neutral component n/a 1272919 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B maged1-pja1-3 1272905 n/a 1272927 unspecified role unspecified role neutral component neutral component n/a 1272918 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 2B magec2-trim28-3 1272906 n/a 1272917 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait direct interaction direct interaction false false false S2B ndnl2-nsmce1-5 1272906 n/a 1272921 unspecified role unspecified role prey prey n/a 1272923 unspecified role unspecified role bait bait direct interaction direct interaction false false false S2C magec2-trim28-4 1272907 n/a 1272917 unspecified role unspecified role neutral component neutral component n/a 1272914 unspecified role unspecified role neutral component neutral component physical association physical association false false false S2D ndnl2-nsmce1-6 1272907 n/a 1272921 unspecified role unspecified role neutral component neutral component n/a 1272923 unspecified role unspecified role neutral component neutral component physical association physical association false false false S2E magec2-trim28-5 1272908 n/a 1272917 unspecified role unspecified role prey prey n/a 1272914 unspecified role unspecified role bait bait physical association physical association false false false 2C and E maged1-pja1-5 1272908 n/a 1272927 unspecified role unspecified role prey prey n/a 1272918 unspecified role unspecified role bait bait physical association physical association false false false 2C magec2-tp53-5 1272909 n/a 1272934 unspecified role unspecified role neutral component neutral component n/a 1272935 ancillary ancillary neutral component neutral component n/a 1272917 ancillary ancillary neutral component neutral component n/a 1272914 enzyme enzyme neutral component neutral component n/a 1272929 enzyme target enzyme target substrate substrate neutral component neutral component ubiquitination ubiquitination reaction ubiquitination false false false 5E and F magea2-tp53-4 1272909 n/a 1272934 unspecified role unspecified role neutral component neutral component n/a 1272913 ancillary ancillary neutral component neutral component n/a 1272929 enzyme target enzyme target substrate substrate neutral component neutral component n/a 1272914 enzyme enzyme neutral component neutral component n/a 1272935 ancillary ancillary neutral component neutral component ubiquitination ubiquitination reaction ubiquitination false false false 5E magec2-tp53-2 1272910 n/a 1272935 ancillary ancillary neutral component neutral component n/a 1272914 enzyme enzyme neutral component neutral component n/a 1272929 enzyme target enzyme target substrate substrate neutral component neutral component n/a 1272930 enzyme enzyme neutral component neutral component n/a 1272917 ancillary ancillary neutral component neutral component association association false false false S5I and J magec2-trim28-7 1272911 n/a 1272917 unspecified role unspecified role bait bait n/a 1272914 unspecified role unspecified role prey prey physical association physical association false false false S6C ndnl2-nsmce1-10 1272912 n/a 1272921 unspecified role unspecified role neutral component neutral component n/a 1272923 unspecified role unspecified role neutral component neutral component direct interaction direct interaction false false false 4 2.92 A working 21.9% ; free 27.0 %