UniProt UniProt http://www.uniprot.org hocevar-2001-1 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hocevar B.A., Smine A., Xu X.X., Howe P.H. howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-2 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hocevar B.A., Smine A., Xu X.X., Howe P.H. howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-3 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. human-ht1080 Homo sapiens HT1080 fribrosarcoma cell line ht1080 confirmed as human with IEF of AST, LDH, NP established from the biopsy from a fibrosarcoma of a 35-year-old Caucasian man in 1972 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Hocevar B.A., Smine A., Xu X.X., Howe P.H. The cell line is the human fibrosarcoma HT1080-derived parental cell line, BAHgpt, which contains the selectable marker Escherichia coli guanine phosphoribosyltransferase (gpt) linked to the TGFbeta-responsive promoter 3TP howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-4 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Hocevar B.A., Smine A., Xu X.X., Howe P.H. howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-5 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 crosslink cross-linking study crosslink anti tag western anti tag western blot anti tag western Hocevar B.A., Smine A., Xu X.X., Howe P.H. howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-6 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. human-ht1080 Homo sapiens HT1080 fribrosarcoma cell line ht1080 confirmed as human with IEF of AST, LDH, NP established from the biopsy from a fibrosarcoma of a 35-year-old Caucasian man in 1972 crosslink cross-linking study crosslink weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hocevar B.A., Smine A., Xu X.X., Howe P.H. The cell line is the human fibrosarcoma HT1080-derived parental cell line, BAHgpt, which contains the selectable marker Escherichia coli guanine phosphoribosyltransferase (gpt) linked to the TGFbeta-responsive promoter 3TP howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation hocevar-2001-7 The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. musvi-mv1lu Mustela vison mink lung epithelial cells Neovison vison mv1lu Mv1Lu mink lung epithelial crosslink cross-linking study crosslink weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Hocevar B.A., Smine A., Xu X.X., Howe P.H. howep@ccf.org EMBO J. (0261-4189) 2001 mimix curation smad2_human Mothers against decapentaplegic homolog 2 SMAD2 MADH2 MADR2 Mad-related protein 2 SMAD family member 2 JV18-1 protein protein human Homo sapiens Human MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS dab2_human Disabled homolog 2 DAB2 DOC2 Differentially-expressed protein 2 Adaptor molecule disabled-2 Differentially expressed in ovarian carcinoma 2 protein protein human Homo sapiens Human MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA smad3_human Mothers against decapentaplegic homolog 3 SMAD3 MADH3 SMAD family member 3 JV15-2 protein protein human Homo sapiens Human MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS tgfr1_human TGF-beta receptor type-1 TGFBR1 Transforming growth factor-beta receptor type I TGF-beta type I receptor Serine/threonine-protein kinase receptor R4 Activin receptor-like kinase 5 ALK5 SKR4 Activin A receptor type II-like protein kinase of 53kD protein protein human Homo sapiens Human MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM tgfr2_human TGF-beta receptor type-2 TGFBR2 Transforming growth factor-beta receptor type II TGF-beta type II receptor protein protein human Homo sapiens Human MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK tgfbr2_musvi_protein protein protein musvi Mustela vison similar to mouse Q62312 UniProt entry dab2_musvi_protein protein protein musvi Mustela vison similar to mouse P98078 Uniprot entry tgfbr1_musvi_protein protein protein musvi Mustela vison similar to mouse Q64729 UniProt entry smad2-dab2 1318914 n/a 1318921 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 5A smad3-dab2 1318914 n/a 1318923 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 5A smad2-dab2-1 1318915 n/a 1318921 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 6A smad3-dab2-1 1318915 n/a 1318923 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 6A smad2-dab2-2 1318916 n/a 1318921 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 7A and B smad3-dab2-2 1318916 n/a 1318922 unspecified role unspecified role prey prey n/a 1318923 unspecified role unspecified role bait bait physical association physical association false false false 7B smad2-dab2-3 1318917 n/a 1318921 unspecified role unspecified role bait bait n/a 1318922 unspecified role unspecified role prey prey physical association physical association false false false 7B dab2-tgfbr1 1318918 n/a 1318924 unspecified role unspecified role prey prey n/a 1318925 unspecified role unspecified role prey prey n/a 1318922 unspecified role unspecified role bait bait association association false false false 8A dab2-tgfbr1-1 1318919 n/a 1318922 unspecified role unspecified role bait bait n/a 1318925 unspecified role unspecified role prey prey n/a 1318924 unspecified role unspecified role prey prey association association false false false 8C dab2-tgfbr1-5 1318920 n/a 1318926 unspecified role unspecified role prey prey n/a 1318927 unspecified role unspecified role bait bait n/a 1318928 unspecified role unspecified role prey prey association association false false false 8C