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    <entry>
        <source releaseDate="2011-10-03+01:00">
            <names>
                <shortLabel>InnateDB</shortLabel>
                <fullName>InnateDB</fullName>
            </names>
            <xref>
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            </xref>
        </source>
        <experimentList>
            <experimentDescription id="1130370">
                <names>
                    <shortLabel>gandhi-2010-4</shortLabel>
                    <fullName>Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="20676092" refType="primary-reference" refTypeAc="MI:0358"/>
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                </bibref>
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                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-293</shortLabel>
                            <fullName>Homo sapiens transformed primary embryonal kidney cells</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>293</shortLabel>
                                <fullName>Transformed human primary embryonal kidney cells.</fullName>
                            </names>
                            <xref>
                                <primaryRef db="mint" dbAc="MI:0471" id="MINT-1782570" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="cabri" dbAc="MI:0246" id="ACC 305" refType="identity" refTypeAc="MI:0356"/>
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                                <secondaryRef db="intact" dbAc="MI:0469" id="IA:0058" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">The Cell type named 293 is synonymous with HEK-293.</attribute>
                            </attributeList>
                        </cellType>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>anti tag western</shortLabel>
                        <fullName>anti tag western blot</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti tag western</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0705" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Gandhi R., Kumar D., Burns EJ., Nadeau M., Dake B., Laroni A., Kozoriz D., Weiner HL., Quintana FJ.</attribute>
                    <attribute name="negative">This experiment relates to a negative interaction.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">fquintana@rics.bwh.harvard.edu</attribute>
                    <attribute name="contact-comment" nameAc="MI:0635">species of foxp3, aiolos cDNA confirmed through author correspondence.</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nat. Immunol. (1529-2908)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2010</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                    <attribute name="external curation">Curated by: InnateDB - a knowledge resource for innate immunity</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="1130371">
                <names>
                    <shortLabel>q9ukt9-14</shortLabel>
                    <fullName>Zinc finger protein Aiolos</fullName>
                    <alias typeAc="MI:0304" type="isoform synonym">Aio-1-5a</alias>
                    <alias typeAc="MI:0301" type="gene name">IKZF3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ZNFN1A3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ikaros family zinc finger protein 3</alias>
                </names>
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                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000161405" version="SP_182" refType="gene"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEDIQTNAELKSTQEQSVPAESAAVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVLMVHKRSHTGERPFQCNQCGASFTQKGNLLRHIKLHTGEKPFKCHLCNYACQRRDALTGHLRTHSVEKPYKCEFCGRSYKQRSSLEEHKERCRTFLQSTDPGDTGTGWGWVELSHLGIRLQDLNVPWCRLH</sequence>
            </interactor>
            <interactor id="1130372">
                <names>
                    <shortLabel>foxp3_human</shortLabel>
                    <fullName>Forkhead box protein P3</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Scurfin</alias>
                    <alias typeAc="MI:0301" type="gene name">FOXP3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">IPEX</alias>
                    <alias typeAc="MI:0306" type="orf name">JM2</alias>
                </names>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050687" secondary="negative regulation of defense response to virus" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002667" secondary="regulation of T cell anergy" version="SP_207"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" secondary="DNA binding" version="SP_207"/>
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                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032354" version="SP_207"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_207"/>
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                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_054728.2"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14DD8" version="SP_68" refType="secondary-ac" refTypeAc="MI:0360"/>
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                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-36584N"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046007" secondary="negative regulation of activated T cell proliferation" version="SP_207"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002513" secondary="tolerance induction to self antigen" version="SP_207"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002851" secondary="positive regulation of peripheral T cell tolerance induction" version="SP_207"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_207"/>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MPNPRPGKPSAPSLALGPSPGASPSWRAAPKASDLLGARGPGGTFQGRDLRGGAHASSSSLNPMPPSQLQLPTLPLVMVAPSGARLGPLPHLQALLQDRPHFMHQLSTVDAHARTPVLQVHPLESPAMISLTPPTTATGVFSLKARPGLPPGINVASLEWVSREPALLCTFPNPSAPRKDSTLSAVPQSSYPLLANGVCKWPGCEKVFEEPEDFLKHCQADHLLDEKGRAQCLLQREMVQSLEQQLVLEKEKLSAMQAHLAGKMALTKASSVASSDKGSCCIVAAGSQGPVVPAWSGPREAPDSLFAVRRHLWGSHGNSTFPEFLHNMDYFKFHNMRPPFTYATLIRWAILEAPEKQRTLNEIYHWFTRMFAFFRNHPATWKNAIRHNLSLHKCFVRVESEKGAVWTVDELEFRKKRSQRPSRCSNPTPGP</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-16943-5" id="1130373">
                <names>
                    <shortLabel>foxp3-q9ukt9_14-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-3989406" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-16943-5" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1130370</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1130374">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-3989431" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1130371</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1130375">
                                <names>
                                    <shortLabel>region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-3989432" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>flag tag</shortLabel>
                                        <fullName>flag tag</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG-tagged</alias>
                                        <alias typeAc="MI:0303" type="go synonym">FLAG</alias>
                                        <alias typeAc="MI:0303" type="go synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">DYKDDDDKV epitope tag</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG</alias>
                                        <alias typeAc="MI:1041" type="synonym">FLAG-tagged</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0518" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456503" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="1130376">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-3989410" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1130372</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>true</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 8B, 8D.</attribute>
                    <attribute name="negative">The interaction does not occur under these experimental conditions.</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
