IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ tan-2008a-1 Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. rat-heart Rattus norvegicus heart heart Heart [Cardiac; Cardiac tissue] anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Tan W.Q., Wang J.X., Lin Z.Q., Li Y.R., Lin Y., Li P.F. Apoptosis - Interactions involving proteins with a function related to apoptosis Interactions involving ARC (phosphorylation assay and co-inmunoprecipitation) were not included because the precise origin of the protein was not stated in the paper. peifli@ioz.ac.cn Circulation (0009-7322) 2008 Only protein-protein interactions imex curation q8r2e7_rat FAS-associated death domain protein rCG_48606 Fadd fadd FAS-associating death domain-containing protein protein protein rat Rattus norvegicus (Rat) Rat MDPFLVLLHSLSSSLSGNDLTDLKFLCRERVSKRKLERVQSGLDLFSVLLEQNDLERGHTGLLRELLASLGRHDLLQRLDDFEAGATTAATPGEADLRVAFDIVCDNVGRDWKRLARELKVSEAKIDGIEERYPRSLSDRVRETLRVWKNVEKENASVAGLVKALRACRLNLVADLVEEALMAQGSVSKSDDTSSALRDSTVSFSETP casp8_rat Caspase-8 Casp8 protein protein rat Rattus norvegicus (Rat) Rat MDFHSCLYDIAERLGNEELAALKFLCLDHIPQKKQESINDVLVLFQRLQEEGMLEEDNLSFLKELLFHISRRDLLSRVLKSSPEEMVRELQVLGKAQVSAYRVMLFKLSEDMDKEDLKSFKFLLITEIPKCKLQDNSSLLDIFVEMEKRTILAENNLVTLKSICFRVNRSLLGRIDDYERSSTERRMSTEGGEELPVSVLDEVTIKMQDMWDSPGEQESESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSKTFKELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFICCILSHGDKGIVYGTDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQACQGNNFQKAVPVPDETGLEQEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSLRERCPRGEDILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFFPPN tnr6_rat Tumor necrosis factor receptor superfamily member 6 Fas Apt1 Tnfrsf6 Apo-1 antigen Apoptosis-mediating surface antigen FAS FASLG receptor protein protein rat Rattus norvegicus (Rat) Rat MLWIMAVLPLVLAGPELNVRMQGTDSIFEGLELKRSVRETDNNCSEGLYQVGPFCCQPCQPGERKVKDCTTSGGAPTCHPCTEGEEYTDRKHYSDKCRRCAFCDEGHGLEVETNCTRTQNTKCRCKENFYCNASLCDHCYHCTSCGLEDILEPCTRTSNTKCKKQSSNYKLLWLLILPGLAILFVFIYKRYRKRQPGDPESGIPSPESVPMNVSDVNLNKYIWRTAEKMKICDAKKFARQHKIPESKIDEIEHNSPQDAAEQKIQLLQCWYQSHGKTGACQALIQGLRKANRCDIAEEIQAMVWEDHENSISNSRNENEGQSLE nol3_rat Nucleolar protein 3 Nol3 Arc Apoptosis repressor with CARD protein protein rat Rattus norvegicus (Rat) Rat MGNMQERPSETIDRERKRLVETLQADSGLLLDALVARGVLTGPEYEALDALPDAERRVRRLLLLVQSKGEAACQELLRCAQQTVSMPDPAWDWQHVGPGYRDRSYDPPCPGHWTPEAPSSGTTCPGLPRASEEEEIGGPEDSEAVQPRTPEEPELEAEATKGDEPDLEQEMEPEPEPEVEPEPEPEPEPEPEPEPEPEPEPEPEREPDFQEGDESEGCENT casp8-fadd-10 1174210 n/a 1174211 unspecified role unspecified role prey prey n/a 1174212 unspecified role unspecified role bait bait physical association physical association false false false 6d Isoprotenerol was required for this endogenous interaction to happen. nol3 over expression disrupted the interaction. fadd-casp8-9 1174210 n/a 1174212 unspecified role unspecified role prey prey n/a 1174211 unspecified role unspecified role bait bait n/a 1174213 unspecified role unspecified role prey prey association association false false false 6d Isoprotenerol was required for this endogenous interaction to happen. nol3 over expression decreased the interaction. casp8-nol3 1174210 n/a 1174214 unspecified role unspecified role prey prey Q62881:p.Thr149Asp mutation disrupting mutation disrupting interaction mutation disrupting mutation analysis mutation analysis certain certain sequence position certain certain certain sequence position certain false n/a 1174212 unspecified role unspecified role bait bait physical association physical association false false false 6d 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) inhibited the interaction.