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                <names>
                    <shortLabel>jia-2008a-1</shortLabel>
                    <fullName>Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.</fullName>
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                            <shortLabel>human</shortLabel>
                            <fullName>Homo sapiens</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
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                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
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                        <shortLabel>western blot</shortLabel>
                        <fullName>western blot</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Immuno blot</alias>
                        <alias typeAc="MI:1041" type="synonym">Immuno blot</alias>
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                    <attribute name="author-list" nameAc="MI:0636">Jia SH., Parodo J., Kapus A., Rotstein OD., Marshall JC.</attribute>
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                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
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                <names>
                    <shortLabel>jia-2008a-2</shortLabel>
                    <fullName>Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8.</fullName>
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                            <shortLabel>crigr-cho</shortLabel>
                            <fullName>chinese hamster ovary cell line</fullName>
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                                <shortLabel>cho</shortLabel>
                                <fullName>chinese hamster ovary cell line</fullName>
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                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">Also called LR73 cells.</attribute>
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                        <shortLabel>anti tag coip</shortLabel>
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                    <alias typeAc="MI:0302" type="gene name synonym">Apoptotic protease Mch-5</alias>
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                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15806" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001219.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097110" secondary="scaffold protein binding" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004197" secondary="cysteine-type endopeptidase activity" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_203519.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002398" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8TDI4" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030225" secondary="macrophage differentiation" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009409" secondary="response to cold" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008625" secondary="extrinsic apoptotic signaling pathway via death domain receptors" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4PS1" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005246946.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75153" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9693928" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001073594.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZBW" version="SP_246"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15780" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14793" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001073593.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013957" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006915" secondary="apoptotic process" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5357905" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1QDU" version="SP_246"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015917" version="SP_246"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5H33" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006712853.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR033170" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005741" secondary="mitochondrial outer membrane" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901216" secondary="positive regulation of neuron death" version="SP_246"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000501268" version="SP_246" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9C0K4" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016129" version="SP_246"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000412523" version="SP_246" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5H31" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010803" secondary="regulation of tumor necrosis factor-mediated signaling pathway" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-140534" version="SP_246"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-933543" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034612" secondary="response to tumor necrosis factor" version="SP_246"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045862" secondary="positive regulation of proteolysis" version="SP_246"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005246945.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q14791" version="SP_107" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_246"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLSFLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSFKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQLMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD</sequence>
            </interactor>
            <interactor id="1243420">
                <names>
                    <shortLabel>ptn6_human</shortLabel>
                    <fullName>Tyrosine-protein phosphatase non-receptor type 6</fullName>
                    <alias typeAc="MI:0301" type="gene name">PTPN6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HCP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein-tyrosine phosphatase 1C</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Hematopoietic cell protein-tyrosine phosphatase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SH-PTP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein-tyrosine phosphatase SHP-1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PTP1C</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P29350" version="SP_99" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31002N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GRZ" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4HJQ" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005001" secondary="transmembrane receptor protein tyrosine phosphatase activity" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" secondary="negative regulation of MAP kinase activity" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029021" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042169" secondary="SH2 domain binding" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050732" secondary="negative regulation of peptidyl-tyrosine phosphorylation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001784" secondary="phosphotyrosine residue binding" version="SP_238"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-78260" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033630" secondary="positive regulation of cell adhesion mediated by integrin" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035335" secondary="peptidyl-tyrosine dephosphorylation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032715" secondary="negative regulation of interleukin-6 production" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-388841" version="SP_238"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000382376"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GS0" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-982772" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1X6C" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035580" secondary="specific granule lumen" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016130" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000387" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" secondary="protein dephosphorylation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-114604" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1FPR" version="SP_238"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28977917" refType="intact-secondary"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002822.2"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000326010"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5690714" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070372" secondary="regulation of ERK1 and ERK2 cascade" version="SP_238"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="G3V0F8" version="SP_156" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-909733" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-512988" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912526" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002924" secondary="negative regulation of humoral immune response mediated by circulating immunoglobulin" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017124" secondary="SH3 domain binding" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070527" secondary="platelet aggregation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0140031" secondary="phosphorylation-dependent protein binding" version="SP_238"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000318974" version="SP_238" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002244" secondary="hematopoietic progenitor cell differentiation" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GWZ" version="SP_238"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000399448"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007186" secondary="G protein-coupled receptor signaling pathway" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2RMX" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045577" secondary="regulation of B cell differentiation" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2B3O" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4GRY" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050853" secondary="B cell receptor signaling pathway" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042267" secondary="natural killer cell mediated cytotoxicity" version="SP_238"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UK67" version="SP_156" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042981" secondary="regulation of apoptotic process" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3PS5" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000045" secondary="regulation of G1/S transition of mitotic cell cycle" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003595" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-210990" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905867" secondary="epididymis development" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051279" secondary="regulation of release of sequestered calcium ion into cytosol" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_238"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_536859.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000391592"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032720" secondary="negative regulation of tumor necrosis factor production" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1433559" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YU7" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-389948" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-877300" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-877312" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014068" secondary="positive regulation of phosphatidylinositol 3-kinase signaling" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035855" secondary="megakaryocyte development" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" secondary="protein tyrosine phosphatase activity" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" secondary="cytokine-mediated signaling pathway" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042105" secondary="alpha-beta T cell receptor complex" version="SP_238"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P29350" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031295" secondary="T cell costimulation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" secondary="intracellular signal transduction" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036860" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018108" secondary="peptidyl-tyrosine phosphorylation" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050839" secondary="cell adhesion molecule binding" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="SP_238"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K306" version="SP_122" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042130" secondary="negative regulation of T cell proliferation" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983695" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033277" secondary="abortive mitotic cell cycle" version="SP_238"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000456013"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904724" secondary="tertiary granule lumen" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050860" secondary="negative regulation of T cell receptor signaling pathway" version="SP_238"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q969V8" version="SP_99" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912694" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-432142" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-391160" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6SM5" version="SP_238"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_536858.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000242" version="SP_238"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012152" version="SP_238"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4HJP" version="SP_238"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9008059" version="SP_238"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011519290.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000326010" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005911" secondary="cell-cell junction" version="SP_238"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060338" secondary="regulation of type I interferon-mediated signaling pathway" version="SP_238"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000111679" version="SP_238" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030220" secondary="platelet formation" version="SP_238"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="1243421">
                <names>
                    <shortLabel>ptpn6-casp8</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296942" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734593" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1243417</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1243422">
                        <names>
                            <shortLabel>casp8_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296945" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734599" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243419</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1243423">
                        <names>
                            <shortLabel>ptn6_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296944" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734597" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243420</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="1243424">
                <names>
                    <shortLabel>casp8-ptpn6</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296949" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734601" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1243417</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1243425">
                        <names>
                            <shortLabel>casp8_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296952" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734607" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243419</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1243426">
                        <names>
                            <shortLabel>ptn6_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296951" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734605" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243420</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="1243427">
                <names>
                    <shortLabel>casp8-ptpn6-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296960" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734655" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1243418</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1243428">
                        <names>
                            <shortLabel>casp8_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296962" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734663" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243419</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1243429">
                                <names>
                                    <shortLabel>undefined mutation</shortLabel>
                                    <fullName>mutation disrupting interaction</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296966" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734665" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation disrupting</shortLabel>
                                        <fullName>mutation disrupting interaction</fullName>
                                        <alias typeAc="MI:1041" type="synonym">mutation disrupting</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0573" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-705401" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>mutation analysis</shortLabel>
                                        <fullName>mutation analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0074" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456810" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="310"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="310"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                                <attributeList>
                                    <attribute name="no-mutation-export"/>
                                </attributeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="1243430">
                        <names>
                            <shortLabel>ptn6_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8296963" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7734661" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1243420</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
