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    <entry>
        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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            <experimentDescription id="1189384">
                <names>
                    <shortLabel>geng-2005-1</shortLabel>
                    <fullName>Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1.</fullName>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="559292">
                        <names>
                            <shortLabel>yeast</shortLabel>
                            <fullName>Saccharomyces cerevisiae</fullName>
                            <alias typeAc="MI:1041" type="synonym">Baker's yeast</alias>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>2 hybrid</shortLabel>
                        <fullName>two hybrid</fullName>
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                        <alias typeAc="MI:0303" type="go synonym">2h</alias>
                        <alias typeAc="MI:0303" type="go synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:0303" type="go synonym">two-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">2-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2H</alias>
                        <alias typeAc="MI:1041" type="synonym">two-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:1041" type="synonym">2h</alias>
                        <alias typeAc="MI:1041" type="synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Y2H</alias>
                        <alias typeAc="MI:1041" type="synonym">Y-2H</alias>
                        <alias typeAc="MI:1041" type="synonym">2 hybrid</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Geng X., Tang RH., Law SK., Tan SM.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">gengxin@ntu.edu.sg</attribute>
                    <attribute name="journal" nameAc="MI:0885">Immunology (0019-2805)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2005</attribute>
                    <attribute name="partial coverage" nameAc="MI:0958">partial coverage</attribute>
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            <experimentDescription id="1189385">
                <names>
                    <shortLabel>geng-2005-2</shortLabel>
                    <fullName>Integrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1.</fullName>
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                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
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                    <names>
                        <shortLabel>pull down</shortLabel>
                        <fullName>pull down</fullName>
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                        <shortLabel>predetermined</shortLabel>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Geng X., Tang RH., Law SK., Tan SM.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">gengxin@ntu.edu.sg</attribute>
                    <attribute name="journal" nameAc="MI:0885">Immunology (0019-2805)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2005</attribute>
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                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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            </experimentDescription>
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        <interactorList>
            <interactor id="1189386">
                <names>
                    <shortLabel>ital_human</shortLabel>
                    <fullName>Integrin alpha-L</fullName>
                    <alias typeAc="MI:0301" type="gene name">ITGAL</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CD11A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Leukocyte adhesion glycoprotein LFA-1 alpha chain</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Leukocyte function-associated molecule 1 alpha chain</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CD11 antigen-like family member A</alias>
                </names>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
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                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD</sequence>
            </interactor>
            <interactor id="1189387">
                <names>
                    <shortLabel>ptprc_human</shortLabel>
                    <fullName>Receptor-type tyrosine-protein phosphatase C</fullName>
                    <alias typeAc="MI:0301" type="gene name">PTPRC</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CD45</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">T200</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Leukocyte common antigen</alias>
                </names>
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                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P08575" version="SP_93" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009986" secondary="cell surface" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043395" secondary="heparan sulfate proteoglycan binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903615" secondary="positive regulation of protein tyrosine phosphatase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904155" secondary="DN2 thymocyte differentiation" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0A0A0MT22" version="SP_207" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR024739" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045588" secondary="positive regulation of gamma-delta T cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005001" secondary="transmembrane receptor protein tyrosine phosphatase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050852" secondary="T cell receptor signaling pathway" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016335" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029021" version="SP_236"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-224N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010332" secondary="response to gamma radiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042110" secondary="T cell activation" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000458322" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001779" secondary="natural killer cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009898" secondary="cytoplasmic side of plasma membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061099" secondary="negative regulation of protein tyrosine kinase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045059" secondary="positive thymic T cell selection" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YGU" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051209" secondary="release of sequestered calcium ion into cytosol" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006469" secondary="negative regulation of protein kinase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006933" secondary="negative regulation of cell adhesion involved in substrate-bound cell migration" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048304" secondary="positive regulation of isotype switching to IgG isotypes" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905451" secondary="positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046425" secondary="regulation of receptor signaling pathway via JAK-STAT" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044770" secondary="cell cycle phase transition" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000573477" version="SP_236" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032059" secondary="bleb" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045060" secondary="negative thymic T cell selection" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001916" secondary="positive regulation of T cell mediated cytotoxicity" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016130" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000387" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" secondary="protein dephosphorylation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030507" secondary="spectrin binding" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1YGR" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030667" secondary="secretory granule membrane" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FMV" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FN7" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000262418" version="SP_236" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048539" secondary="bone marrow development" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030506" secondary="ankyrin binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903979" secondary="negative regulation of microglial cell activation" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000081237" version="SP_236" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000187" secondary="activation of MAPK activity" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6798695" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032677" secondary="regulation of interleukin-8 production" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031668" secondary="cellular response to extracellular stimulus" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001238" secondary="positive regulation of extrinsic apoptotic signaling pathway" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000648" secondary="positive regulation of stem cell proliferation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008201" secondary="heparin binding" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061097" secondary="regulation of protein tyrosine kinase activity" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003961" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001915" secondary="negative regulation of T cell mediated cytotoxicity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002244" secondary="hematopoietic progenitor cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" secondary="external side of plasma membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042100" secondary="B cell proliferation" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036116" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042098" secondary="T cell proliferation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000442510" version="SP_236" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044855" secondary="plasma membrane raft distribution" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006711535.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030890" secondary="positive regulation of B cell proliferation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007159" secondary="leukocyte cell-cell adhesion" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046641" secondary="positive regulation of alpha-beta T cell proliferation" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003595" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" secondary="regulation of gene expression" version="SP_236"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1341" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050853" secondary="B cell receptor signaling pathway" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007166" secondary="cell surface receptor signaling pathway" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_563578.2"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q16614" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002639" secondary="positive regulation of immunoglobulin production" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000573679" version="SP_236" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031953" secondary="negative regulation of protein autophosphorylation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030217" secondary="T cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032743" secondary="positive regulation of interleukin-2 production" version="SP_236"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P08575" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006711536.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016311" secondary="dephosphorylation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030183" secondary="B cell differentiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050857" secondary="positive regulation of antigen receptor-mediated signaling pathway" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="X6R433" version="SP_207" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048864" secondary="stem cell development" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042102" secondary="positive regulation of T cell proliferation" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K7W6" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051607" secondary="defense response to virus" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" secondary="protein tyrosine phosphatase activity" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000411355" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098857" secondary="membrane microdomain" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043410" secondary="positive regulation of MAPK cascade" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000473" secondary="positive regulation of hematopoietic stem cell migration" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050764" secondary="regulation of phagocytosis" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000461074" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006711537.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FN6" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045121" secondary="membrane raft" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035584" secondary="calcium-mediated signaling using intracellular calcium source" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002829.3"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202427" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001960" secondary="negative regulation of cytokine-mediated signaling pathway" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034113" secondary="heterotypic cell-cell adhesion" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-416700" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H0Y6" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002925" secondary="positive regulation of humoral immune response mediated by circulating immunoglobulin" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032703" secondary="negative regulation of interleukin-2 production" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045860" secondary="positive regulation of protein kinase activity" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070373" secondary="negative regulation of ERK1 and ERK2 cascade" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000242" version="SP_236"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="1189388">
                <names>
                    <shortLabel>itgal-ptprc</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213325" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654192" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1189384</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1189389">
                        <names>
                            <shortLabel>ital_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213328" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654197" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1189386</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1189390">
                        <names>
                            <shortLabel>ptprc_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213327" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654199" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1189387</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">f1</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="1189391">
                <names>
                    <shortLabel>itgal-ptprc-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213340" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654267" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1189385</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1189392">
                        <names>
                            <shortLabel>ital_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213343" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654274" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1189386</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1189393">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213355" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654281" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1088"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="1145"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="1189394">
                        <names>
                            <shortLabel>ptprc_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8213342" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7654272" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1189387</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="figure legend" nameAc="MI:0599">f3 f4b f6</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
