MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint tan-2001b-3 The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. in vitro In vitro phosphatase assay phosphatase assay predetermined predetermined participant predetermined Tan KM., Chan SL., Tan KO., Yu VC. J. Biol. Chem. (0021-9258) 2001 partial coverage rapid curation tan-2001b-1 The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. in vitro In vitro pull down pull down predetermined predetermined participant predetermined Tan KM., Chan SL., Tan KO., Yu VC. J. Biol. Chem. (0021-9258) 2001 partial coverage rapid curation tan-2001b-2 The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Tan KM., Chan SL., Tan KO., Yu VC. J. Biol. Chem. (0021-9258) 2001 partial coverage rapid curation kcc2a_human Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A CAMKA KIAA0968 protein protein human Homo sapiens Human MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH ppm1f_human Protein phosphatase 1F Ca(2+)/calmodulin-dependent protein kinase phosphatase Partner of PIX 2 PPM1F KIAA0015 POPX2 Protein fem-2 homolog protein protein human Homo sapiens Human MSSGAPQKSSPMASGAEETPGFLDTLLQDFPALLNPEDPLPWKAPGTVLSQEEVEGELAELAMGFLGSRKAPPPLAAALAHEAVSQLLQTDLSEFRKLPREEEEEEEDDDEEEKAPVTLLDAQSLAQSFFNRLWEVAGQWQKQVPLAARASQRQWLVSIHAIRNTRRKMEDRHVSLPSFNQLFGLSDPVNRAYFAVFDGHGGVDAARYAAVHVHTNAARQPELPTDPEGALREAFRRTDQMFLRKAKRERLQSGTTGVCALIAGATLHVAWLGDSQVILVQQGQVVKLMEPHRPERQDEKARIEALGGFVSHMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRALTGSEDYLLLACDGFFDVVPHQEVVGLVQSHLTRQQGSGLRVAEELVAAARERGSHDNITVMVVFLRDPQELLEGGNQGEGDPQAEGRRQDLPSSLPEPETQAPPRS fem2_caeel Protein phosphatase fem-2 Ca(2+)/calmodulin-dependent protein kinase phosphatase fem-2 Sex-determining protein fem-2 Feminization of XX and XO animals protein 2 T19C3.8 protein protein caeel Caenorhabditis elegans MEKVNEERDAVFEDHIGDRRRSVRSLLEEAFADEMEKTSYDVEVADTPQPHIPIRFRHPPIAGPVHDVFGDAIHDIFQKMMKRGQAVDFCHWVSHLIATEIDEKFSEVAFRDVQYNPDIYVTDSTTEAKKLFNDKIWPAIDKILQQNAETCPILSEKWSGIHVSGDQLKGQRHKQEDRFLAYPNGQYMDRGEDPISVLAVFDGHGGHECSQYAAGHLWETWLEVRKSRDPSDSLEDQLRKSLELLDERMTVRSVKECWKGGSTAVCCAIDMDQKLMALAWLGDSPGYVMSNIEFRQLTRGHSPSDEREARRVEEAGGQLFVIGGELRVNGVLNLTRALGDVPGRPMISNEPETCQVPIESSDYLVLLACDGISDVFNERDLYQLVEAFANDYPVEDYAELSRFICTKAIEAGSADNVSVVIGFLRPPQDVWKLMKHESDDEDSDVTDEE ppm1f_rat Protein phosphatase 1F Ppm1f Popx2 Ca(2+)/calmodulin-dependent protein kinase phosphatase Partner of PIX 2 protein protein rat Rattus norvegicus (Rat) Rat MASGAPQNSSQMACDGEIPGFLDTLLQDFPAPLSLESPLPWKVPGTVLGQEEVEAELTELAMGFLGSRNAPPAVAAAVTHEAISQLLQTDLSEFKRLPEQEEEEEEEEERVLTTLLDAKGLSRSFFNCLWEVCSQWQKRVPLTAQAPQRKWLVSIHAIRNTRRKMEDRHVSLPAFNHLFGLSDSVHRAYFAVFDGHGGVDAARYASVHVHTNASHQPELLTDPAAALKEAFRHTDQMFLQKAKRERLQSGTTGVCALITGAALHVAWLGDSQVILVQQGQVVKLMEPHKPERQDEKSRIEALGGFVSLMDCWRVNGTLAVSRAIGDVFQKPYVSGEADAASRELTGLEDYLLLACDGFFDVVPHHEIPGLVHGHLLRQKGSGMHVAEELVAVARDRGSHDNITVMVVFLRDPLELLEGGGQGAGGAQADVGSQDLSTGLSELEINTSQRS mint Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis fem1b_human Protein fem-1 homolog B FEM1B KIAA0396 F1AA FEM1-beta Fem-1-like death receptor-binding protein alpha Fem-1-like in apoptotic pathway protein alpha protein protein human Homo sapiens Human MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIIKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELESIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIHLDPRTREGFTLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH camk2a-ppm1f 1190398 kcc2a_human 1190401 enzyme target enzyme target substrate substrate unspecified role unspecified role Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated) ppm1f_human 1190402 enzyme enzyme unspecified role unspecified role dephosphorylation dephosphorylation reaction dephosphorylation false false false f3 homomint mint camk2a-fem_2 1190398 fem2_caeel 1190403 enzyme enzyme unspecified role unspecified role kcc2a_human 1190401 enzyme target enzyme target substrate substrate unspecified role unspecified role Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated) dephosphorylation dephosphorylation reaction dephosphorylation false false false f3 mint camk2a-ppm1f-1 1190398 ppm1f_rat 1190404 enzyme enzyme unspecified role unspecified role kcc2a_human 1190401 enzyme target enzyme target substrate substrate unspecified role unspecified role Resulting Phenotypic qualities (properties)[PATO]: PATO:0002263 (dephosphorylated) dephosphorylation dephosphorylation reaction dephosphorylation false false false f3 homomint mint ppm1f-fem1b 1190399 ppm1f_human 1190402 unspecified role unspecified role bait bait fem1b_human 1190405 unspecified role unspecified role prey prey direct interaction direct interaction false false false f5b homomint mint ppm1f-fem1b-1 1190400 fem1b_human 1190405 unspecified role unspecified role prey prey ppm1f_human 1190402 unspecified role unspecified role bait bait physical association physical association false false false f5a homomint mint