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                    <shortLabel>brondello-1999-1</shortLabel>
                    <fullName>Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Brondello JM., Pouysségur J., McKenzie FR.</attribute>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0120041" secondary="positive regulation of macrophage proliferation" version="SP_236"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP</sequence>
            </interactor>
            <interactor id="1230308">
                <names>
                    <shortLabel>dus1_human</shortLabel>
                    <fullName>Dual specificity protein phosphatase 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Mitogen-activated protein kinase phosphatase 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein-tyrosine phosphatase CL100</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Dual specificity protein phosphatase hVH1</alias>
                    <alias typeAc="MI:0301" type="gene name">DUSP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CL100</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MKP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PTPN10</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">VH1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P28562" version="SP_78" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070373" secondary="negative regulation of ERK1 and ERK2 cascade" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020422" version="SP_200"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-975493" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032870" secondary="cellular response to hormone stimulus" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008330" secondary="protein tyrosine/threonine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006470" secondary="protein dephosphorylation" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029021" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009416" secondary="response to light stimulus" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070262" secondary="peptidyl-serine dephosphorylation" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000387" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033574" secondary="response to testosterone" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051447" secondary="negative regulation of meiotic cell cycle" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032526" secondary="response to retinoic acid" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106306" secondary="protein serine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000239223" version="SP_200" refType="transcript"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P28562" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004722" secondary="protein serine/threonine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106307" secondary="protein threonine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008343" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003595" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" secondary="cell cycle" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043409" secondary="negative regulation of MAPK cascade" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001706" secondary="endoderm formation" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000340" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016130" version="SP_200"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000120129" version="SP_200" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903753" secondary="negative regulation of p38MAPK cascade" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990869" secondary="cellular response to chemokine" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035335" secondary="peptidyl-tyrosine dephosphorylation" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090027" secondary="negative regulation of monocyte chemotaxis" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019838" secondary="growth factor binding" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" secondary="response to cAMP" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000188" secondary="inactivation of MAPK activity" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008138" secondary="protein tyrosine/serine/threonine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D67" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000279" secondary="negative regulation of DNA biosynthetic process" version="SP_200"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D65" version="SP_200"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6APX" version="SP_200"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-112409" version="SP_200"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2V508" version="SP_78" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042542" secondary="response to hydrogen peroxide" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051019" secondary="mitogen-activated protein kinase binding" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035970" secondary="peptidyl-threonine dephosphorylation" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090266" secondary="regulation of mitotic cell cycle spindle assembly checkpoint" version="SP_200"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001763" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" secondary="protein tyrosine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6D66" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051384" secondary="response to glucocorticoid" version="SP_200"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000239223" version="SP_200" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036873" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" secondary="intracellular signal transduction" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043407" secondary="negative regulation of MAP kinase activity" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043066" secondary="negative regulation of apoptotic process" version="SP_200"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DQL9" version="SP_108" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004408.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" secondary="response to estradiol" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007162" secondary="negative regulation of cell adhesion" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051592" secondary="response to calcium ion" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" secondary="phosphoprotein phosphatase activity" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017017" secondary="MAP kinase tyrosine/serine/threonine phosphatase activity" version="SP_200"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5675221" version="SP_200"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="1230309">
                <names>
                    <shortLabel>dusp1-mapk3-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238422" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7164842" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>1230306</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1230310">
                        <names>
                            <shortLabel>mk03_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238425" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7164849" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1230307</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>enzyme</shortLabel>
                                <fullName>enzyme</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0501" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-46" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1230311">
                        <names>
                            <shortLabel>dusp1</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8238424" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7164847" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1230308</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>enzyme target</shortLabel>
                                <fullName>enzyme target</fullName>
                                <alias typeAc="MI:0303" type="go synonym">substrate</alias>
                                <alias typeAc="MI:1041" type="synonym">substrate</alias>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0502" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-64" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>phosphorylation</shortLabel>
                        <fullName>phosphorylation reaction</fullName>
                        <alias typeAc="MI:1041" type="synonym">phosphorylation</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0217" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0039" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0033" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0034" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="go" dbAc="MI:0448" id="GO:0016310" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49922" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0035" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0222" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0037" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0036" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0038" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F3A</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
