MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint blancoap-1999-1 A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. in vitro In vitro phosphatase assay phosphatase assay predetermined predetermined participant predetermined Blanco-Aparicio C., Torres J., Pulido R. J. Cell Biol. (0021-9525) 1999 partial coverage rapid curation blancoap-1999-2 A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. chlae Chlorocebus aethiops Cercopithecus aethiops Grivet Green monkey fluorescence imaging fluorescence microscopy fluorescence imaging predetermined predetermined participant predetermined Blanco-Aparicio C., Torres J., Pulido R. J. Cell Biol. (0021-9525) 1999 partial coverage rapid curation blanco_apar-1999-1 A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Blanco-Aparicio C., Torres J., Pulido R. J. Cell Biol. (0021-9525) 1999 partial coverage rapid curation mk01_human Mitogen-activated protein kinase 1 MAPK1 ERK2 PRKM1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase isoform p42 ERT1 PRKM2 protein protein human Homo sapiens Human MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS ptprr_human Receptor-type tyrosine-protein phosphatase R PTPRR ECPTP PTPRQ Protein-tyrosine phosphatase PCPTP1 NC-PTPCOM1 Ch-1PTPase protein protein human Homo sapiens Human MRRAVCFPALCLLLNLHAAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESRLSAETVQ mk14_human Mitogen-activated protein kinase 14 Mitogen-activated protein kinase p38 alpha Cytokine suppressive anti-inflammatory drug-binding protein MAX-interacting protein 2 MAP kinase MXI2 SAPK2A MAPK14 CSBP CSBP1 CSBP2 CSPB1 MXI2 Stress-activated protein kinase 2a protein protein human Homo sapiens Human MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES mapk1-ptprr-4 1189360 mk01_human ERK2 1189363 enzyme target enzyme target substrate substrate neutral component neutral component Resulting Phenotypic qualities (properties)[PATO]: PATO:0002221 (increased phosphorylation) ptprr_human PTPRR 1189364 enzyme enzyme neutral component neutral component Q15256:p.Ser339Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false f2d homomint mint mapk14-ptprr 1189360 mk14_human p38 1189365 enzyme target enzyme target substrate substrate neutral component neutral component Resulting Phenotypic qualities (properties)[PATO]: PATO:0002221 (increased phosphorylation) ptprr_human PTPRR 1189364 enzyme enzyme neutral component neutral component Q15256:p.Ser339Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false f2d homomint mint mapk1-ptprr-5 1189361 mk01_human ERK2 1189363 unspecified role unspecified role neutral component neutral component ptprr_human PTPRR 1189364 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false f3 homomint mint mapk14-ptprr-1 1189361 ptprr_human PTPRR 1189364 unspecified role unspecified role neutral component neutral component mk14_human p38 1189365 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false f3 homomint mint ptprr-mapk14-1 1189362 ptprr_human PTPRR 1189364 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell Q15256:p.Ser339Glu mutation disrupting mutation disrupting interaction mutation disrupting certain certain sequence position certain certain certain sequence position certain false mk14_human p38 1189365 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association false false false f2c homomint mint