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        <source releaseDate="2013-09-02+01:00">
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                    <shortLabel>zenke-2004-1</shortLabel>
                    <fullName>p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.</fullName>
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                        <names>
                            <shortLabel>unknown</shortLabel>
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                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Zenke FT., Krendel M., DerMardirossian C., King CC., Bohl BP., Bokoch GM.</attribute>
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                    <attribute name="publication year" nameAc="MI:0886">2004</attribute>
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                    <fullName>14-3-3 protein zeta/delta</fullName>
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                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
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                <sequence>MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN</sequence>
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                    <fullName>Rho guanine nucleotide exchange factor 2</fullName>
                    <alias typeAc="MI:0301" type="gene name">ARHGEF2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">KIAA0651</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">LFP40</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Guanine nucleotide exchange factor H1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Microtubule-regulated Rho-GEF</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Proliferating cell nucleolar antigen p40</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q92974" version="SP_72" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071474" secondary="cellular hyperosmotic response" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-416482" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032755" secondary="positive regulation of interleukin-6 production" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" secondary="regulation of cell population proliferation" version="SP_209"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H023" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032587" secondary="ruffle membrane" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000902" secondary="cell morphogenesis" version="SP_209"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1045693" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031982" secondary="vesicle" version="SP_209"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EFX" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005819" secondary="spindle" version="SP_209"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8TDA3" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR002219" version="SP_209"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001155855.1"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5VY92" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000219" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035023" secondary="regulation of Rho protein signal transduction" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-193648" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060546" secondary="negative regulation of necroptotic process" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902042" secondary="negative regulation of extrinsic apoptotic signaling pathway via death domain receptors" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8980692" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" secondary="cell cycle" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005874" secondary="microtubule" version="SP_209"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000116584" version="SP_209" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031410" secondary="cytoplasmic vesicle" version="SP_209"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035899" version="SP_209"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000354837" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055059" secondary="asymmetric neuroblast division" version="SP_209"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001849" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005856" secondary="cytoskeleton" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" secondary="glutamatergic synapse" version="SP_209"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9013026" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007015" secondary="actin filament organization" version="SP_209"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001155856.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR041020" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045087" secondary="innate immune response" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007026" secondary="negative regulation of microtubule depolymerization" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005925" secondary="focal adhesion" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045666" secondary="positive regulation of neuron differentiation" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" secondary="transcription factor binding" version="SP_209"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q92974" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005085" secondary="guanyl-nucleotide exchange factor activity" version="SP_209"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O75142" version="SP_72" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004714.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099092" secondary="postsynaptic density, intracellular component" version="SP_209"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DVA6" version="SP_110" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037806" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031267" secondary="small GTPase binding" version="SP_209"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q15079" version="SP_72" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8WUG4" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" secondary="protein-containing complex" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006886" secondary="intracellular protein transport" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008270" secondary="zinc ion binding" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051056" secondary="regulation of small GTPase mediated signal transduction" version="SP_209"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000361247" version="SP_209" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" secondary="intracellular signal transduction" version="SP_209"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011993" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071356" secondary="cellular response to tumor necrosis factor" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008017" secondary="microtubule binding" version="SP_209"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-302405" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005923" secondary="bicellular tight junction" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001224" secondary="positive regulation of neuron migration" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071225" secondary="cellular response to muramyl dipeptide" version="SP_209"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902219" secondary="negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress" version="SP_209"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVTTRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPEETESRDGEAVASES</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="984277">
                <names>
                    <shortLabel>arhgef2-ywhaz</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006660" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7138371" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>984274</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="984278">
                        <names>
                            <shortLabel>1433z_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">1433Z_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006661" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P63104" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7138380" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>984275</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="984279">
                        <names>
                            <shortLabel>arhg2_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">ARHG2_HUMAN</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-8006664" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q92974" refType="original identifier" refTypeAc="MI:0869"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7138376" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>984276</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">domino</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
