MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint grabbe-2006-1 Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 Blood (0006-4971) 2006 mimix curation mimix curation grabbe-2006-2 Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. chick Gallus gallus (Chicken) Chicken anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 Blood (0006-4971) 2006 mimix curation mimix curation grabbe-2006-3 Human SLP-65 isoforms contribute differently to activation and apoptosis of B lymphocytes. in vitro In vitro pull down pull down predetermined predetermined participant predetermined Grabbe A., Wienands J. SH3 Blood (0006-4971) 2006 mimix curation mimix curation blnk_human B-cell linker protein BASH SLP65 B-cell adapter containing a SH2 domain protein B-cell adapter containing a Src homology 2 domain protein Cytoplasmic adapter protein Src homology 2 domain-containing leukocyte protein of 65 kDa BLNK protein protein human Homo sapiens Human MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS grb2_human Growth factor receptor-bound protein 2 GRB2 ASH Adapter protein GRB2 SH2/SH3 adapter GRB2 Protein Ash protein protein human Homo sapiens Human MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV blnk_chick B-cell linker protein BLNK BASH Cytoplasmic adapter protein B-cell adapter SH2 domain-containing protein Src homology 2 domain-containing leukocyte protein of 65 kDa protein protein chick Gallus gallus (Chicken) Chicken MDKLNKLAVPAGEKFRKLQKMVHDIKKNESGIINKFKKFQNEQVALICKTGKDTWDRLKKKPPPSLPRRDYASEHADNEEEQWSDDFDSDYENPDGHSDSEMYVVPSEENPDDSYEPPPSEQEKKKIPSSFPISRGEYADNRTSHHQLPPINKPLPSTPSSALPRPKKPSLPSPAAKPKLPLKPRECSDDEDNYIVPVDNDDDNYIEPTESSTPPPAKPPVNRFMKPPAKSALPTPPKPSLASDMQEVYEVPEEEEELSPPPVTRFTKPLPATRAQNAEHSHMHSMTRESPKLDASRNILPLPRNRLHPKTDHEANNNDENHSFSNTQESKFPPGAAPSPLPRALKKTSNAVNPAKPCLPSRDTFTVNEDKPTAADRRRGSSHEFPLPPLPSGTPKSSLQKPLVLPKVPEAPSRALGTSPHSSISSISSTADQDAGVHSKAWYAATCDRKTAEDALYRSNKDGSFLIRKSSGQDSRQPYTLVVFYNRRVYNIPIRFIESTRQYALGREKCGEERFDSVAEIVENHQHTSLVLIDSQNNTKDSTKLKYIVRVS mint May function as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays an important role in BCR-mediated PLCG1 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays a critical role in B-cell development in the bursa plcg2 plcg2 protein protein chick Gallus gallus (Chicken) Chicken mint q8uux6_chick VAV3 RCJMB04_7l6 protein protein chick Gallus gallus (Chicken) Chicken MEPWKQCGQWLISCKVLPPNHRVTWETAQVFDLAQTLRDGVLLCQLLNNLRSHSINLKEINLRPQMSQFLCLKNIRTFLSACCEIFGMKKSELFEAFDLFDVRDFGKVIETLSKLSRTPIAIGTGIRPFPTEESVDDEDVYKCLPDLIDETGVDEDEELYDCVYGEDEGGEVYEDLMKDEAAQQPKHTENDVRSCCLAEIKQTEEKYTETLESIEKFFMVPLKRFMSASEFETVFINIPDLVKIHRSLTQDISDSIINKNDQNLYQIFINYKERLVIYGQYCSQVETAISCLDNISKTKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPMEKANLKLALDAMKDLAQYVNEVKRDNETLREIRQFQLSIENLNHSLLQYGRPQGDGEIRITTLDKRARQDRHIFLFDLAVIVCKRRGDNYEMKEIIDLQKYKITNNPTTDKENKKWSYGFYLIHIQGQNGLEVYCKTKDLKKKWLEQFQMALSNIRPDYADTSFHEFKMHTFSRVTSCKVCQMLLRGTFYQGYLCSKCGAGAHKECLGRLDNCGRANSGEHGNLKHEKRTNGIRRNSRHVDPGLPRMQVIRNYKGIPQPTPQDGPPLHIQIGDTIELITGDVHSLFWQGRNLTTGELGFFPSDAVKPSPCVPKPVDYSSQLWFAGAMERLQAESELINRVNSTYLVRHRTKESGEYAISIKYNNEVKHIKIFTRDGYFHITENRKFINLMELVDYYKHHSLKEGFRSLDTTLQFPYKESENSVGQRGNRAGGNLLSPKVIGIAIARYDFCARDMRELSLLKGDVVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE mint grb2_mouse Growth factor receptor-bound protein 2 Grb2 Adapter protein GRB2 SH2/SH3 adapter GRB2 protein protein mouse Mus musculus Mouse MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQMPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV blnk-grb2 824324 blnk_human SLP65 824327 unspecified role unspecified role bait bait grb2_human GRB2 824328 unspecified role unspecified role prey prey binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false direct interaction direct interaction false false false 824324 f1c homomint domino mint blnk-grb2-1 824324 grb2_human GRB2 824328 unspecified role unspecified role prey prey blnk_human SLP65 824327 unspecified role unspecified role bait bait direct interaction direct interaction false false false 824324 f1c homomint mint plcg2-blnk 824325 blnk_chick slp65 824329 unspecified role unspecified role prey prey plcg2 plc gamma2 824330 unspecified role unspecified role bait bait physical association physical association false false false f2b mint vav3-blnk 824325 q8uux6_chick vav3 824331 unspecified role unspecified role bait bait blnk_chick slp65 824329 unspecified role unspecified role prey prey physical association physical association false false false f2b homomint mint grb2-blnk-5 824326 blnk_human SLP65 824327 unspecified role unspecified role prey prey grb2_human Grb2 824328 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false gst tagged gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false f1b homomint domino mint blnk-grb2-2 824326 blnk_human SLP65 824327 unspecified role unspecified role bait bait binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false biotin tagged biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false grb2_mouse Grb2 824332 unspecified role unspecified role prey prey physical association physical association false false false f1d homomint domino mint