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                    <shortLabel>helin-1991-1</shortLabel>
                    <fullName>Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines.</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Helin K., Beguinot L.</attribute>
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                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1991</attribute>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016301" secondary="kinase activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048661" secondary="positive regulation of smooth muscle cell proliferation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007169" secondary="transmembrane receptor protein tyrosine kinase signaling pathway" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1227986" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048408" secondary="epidermal growth factor binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901224" secondary="positive regulation of NIK/NF-kappaB signaling" version="SP_231"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6296235" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043586" secondary="tongue development" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097708" secondary="intracellular vesicle" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009030" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071230" secondary="cellular response to amino acid stimulus" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9009391" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033590" secondary="response to cobalamin" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043406" secondary="positive regulation of MAP kinase activity" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1963642" version="SP_231"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MRPSGTARTTLLVLLTALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMYNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRGRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGIRKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSATSNNSTVACINRNGSCRVKEDAFLQRYSSDPTGAVTEDNIDDAFLPVPEYVNQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVGNPEYLNTAQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKETKPNGIFKGPTAENAEYLRVAPPSSEFIGA</sequence>
            </interactor>
            <interactor id="720896">
                <names>
                    <shortLabel>egf_mouse</shortLabel>
                    <fullName>Pro-epidermal growth factor</fullName>
                    <alias typeAc="MI:0301" type="gene name">Egf</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P01132" version="SP_103" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9QNX6" version="SP_137" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000028017" version="SP_221" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045740" secondary="positive regulation of DNA replication" version="SP_221"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000029653" version="SP_221" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-6785631" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1227986" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000152" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005509" secondary="calcium ion binding" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8847993" version="SP_221"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P01132" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016317" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-180336" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GK5" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EPJ" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008083" secondary="growth factor activity" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8856825" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018097" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018108" secondary="peptidyl-tyrosine phosphorylation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005615" secondary="extracellular space" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046425" secondary="regulation of receptor signaling pathway via JAK-STAT" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051223" secondary="regulation of protein transport" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061098" secondary="positive regulation of protein tyrosine kinase activity" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010800" secondary="positive regulation of peptidyl-threonine phosphorylation" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EPH" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048754" secondary="branching morphogenesis of an epithelial tube" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070371" secondary="ERK1 and ERK2 cascade" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000008" secondary="regulation of protein localization to cell surface" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045741" secondary="positive regulation of epidermal growth factor-activated receptor activity" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001881" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9013507" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000742" version="SP_221"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1782803" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-212718" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1250196" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-6811558" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001525" secondary="angiogenesis" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051048" secondary="negative regulation of secretion" version="SP_221"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-5762N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EGF" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045840" secondary="positive regulation of mitotic nuclear division" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1257604" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060749" secondary="mammary gland alveolus development" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8863795" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-177929" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050708" secondary="regulation of protein secretion" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-180292" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001938" secondary="positive regulation of endothelial cell proliferation" version="SP_221"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q569W5" version="SP_137" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090279" secondary="regulation of calcium ion import" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005576" secondary="extracellular region" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014068" secondary="positive regulation of phosphatidylinositol 3-kinase signaling" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048146" secondary="positive regulation of fibroblast proliferation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005085" secondary="guanyl-nucleotide exchange factor activity" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011042" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007173" secondary="epidermal growth factor receptor signaling pathway" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042327" secondary="positive regulation of phosphorylation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005154" secondary="epidermal growth factor receptor binding" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-179812" version="SP_221"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6P9J2" version="SP_103" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0021940" secondary="positive regulation of cerebellar granule cell precursor proliferation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043410" secondary="positive regulation of MAPK cascade" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000573" secondary="positive regulation of DNA biosynthetic process" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-182971" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000060" secondary="positive regulation of ubiquitin-dependent protein catabolic process" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016021" secondary="integral component of membrane" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-5673001" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038029" secondary="epidermal growth factor receptor signaling pathway via MAPK cascade" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010595" secondary="positive regulation of endothelial cell migration" version="SP_221"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_034243.2"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1236394" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1963642" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8856828" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902966" secondary="positive regulation of protein localization to early endosome" version="SP_221"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUST00000029653" version="SP_221" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000033" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070374" secondary="positive regulation of ERK1 and ERK2 cascade" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090263" secondary="positive regulation of canonical Wnt signaling pathway" version="SP_221"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009030" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043388" secondary="positive regulation of DNA binding" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EPI" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043406" secondary="positive regulation of MAP kinase activity" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-9009391" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905278" secondary="positive regulation of epithelial tube formation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002092" secondary="positive regulation of receptor internalization" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051897" secondary="positive regulation of protein kinase B signaling" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3EGF" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1A3P" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050731" secondary="positive regulation of peptidyl-tyrosine phosphorylation" version="SP_221"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1EPG" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050730" secondary="regulation of peptidyl-tyrosine phosphorylation" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090370" secondary="negative regulation of cholesterol efflux" version="SP_221"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-114608" version="SP_221"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900127" secondary="positive regulation of hyaluronan biosynthetic process" version="SP_221"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MPWGRRPTWLLLAFLLVFLKISILSVTAWQTGNCQPGPLERSERSGTCAGPAPFLVFSQGKSISRIDPDGTNHQQLVVDAGISADMDIHYKKERLYWVDVERQVLLRVFLNGTGLEKVCNVERKVSGLAIDWIDDEVLWVDQQNGVITVTDMTGKNSRVLLSSLKHPSNIAVDPIERLMFWSSEVTGSLHRAHLKGVDVKTLLETGGISVLTLDVLDKRLFWVQDSGEGSHAYIHSCDYEGGSVRLIRHQARHSLSSMAFFGDRIFYSVLKSKAIWIANKHTGKDTVRINLHPSFVTPGKLMVVHPRAQPRTEDAAKDPDPELLKQRGRPCRFGLCERDPKSHSSACAEGYTLSRDRKYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCHELVSCPGNVSKCSHGCVLTSDGPRCICPAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWECDCFPGYDLQSDRKSCAASGPQPLLLFANSQDIRHMHFDGTDYKVLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLSGKHHRIIIQERISRPRGIAVHPRARRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITIDYLTDTLYWCDTKRSVIEMANLDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTGQNRVRLQGSMLKPSSLVVVHPLAKPGADPCLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMCLPQDYPILSGENADLSKEVTSLSNSTQAEVPDDDGTESSTLVAEIMVSGMNYEDDCGPGGCGSHARCVSDGETAECQCLKGFARDGNLCSDIDECVLARSDCPSTSSRCINTEGGYVCRCSEGYEGDGISCFDIDECQRGAHNCGENAACTNTEGGYNCTCAGRPSSPGLSCPDSTAPSLLGEDGHHLDRNSYPGCPSSYDGYCLNGGVCMHIESLDSYTCNCVIGYSGDRCQTRDLRWWELRHAGYGQKHDIMVVAVCMVALVLLLVLGMWGTYYYRTRKQLSNPPKNPCDEPSGSVSSSGPNSSSGAAVASCPQPWFVVLEKHQDPKNGSLPADGTNGAVVDAGLSPSLQLGSVHLTSWRQKPHIDGMGTGQSCWIPPSSDRGPQEIEGNSHLPSYRPVGPEKLHSLQSANGSCHERAPDLPRQTEPVQ</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="720897">
                <names>
                    <shortLabel>egf-egfr-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6169276" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7853849" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>720894</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="720898">
                        <names>
                            <shortLabel>egfr_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">Egfr</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6169279" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7853856" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>720895</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>predetermined</shortLabel>
                                    <fullName>predetermined participant</fullName>
                                    <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                    <participant id="720899">
                        <names>
                            <shortLabel>egf_mouse</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6169278" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7853854" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>720896</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>predetermined</shortLabel>
                                    <fullName>predetermined participant</fullName>
                                    <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F3</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
