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    <entry>
        <source releaseDate="2013-09-02+01:00">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
            </names>
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            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
                <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
                <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
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                <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
                <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="758822">
                <names>
                    <shortLabel>zanier-2005-1</shortLabel>
                    <fullName>Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance.</fullName>
                </names>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-3">
                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>spr</shortLabel>
                        <fullName>surface plasmon resonance</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Optical biosensor</alias>
                        <alias typeAc="MI:0303" type="go synonym">BIAcore(r)</alias>
                        <alias typeAc="MI:1041" type="synonym">BIAcore(r)</alias>
                        <alias typeAc="MI:1041" type="synonym">Optical biosensor</alias>
                        <alias typeAc="MI:1041" type="synonym">spr</alias>
                    </names>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Zanier K., Charbonnier S., Baltzinger M., Nominé Y., Altschuh D., Travé G.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">zanier@titus.u-strasbg.fr</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Mol. Biol. (0022-2836)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2005</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="758823">
                <names>
                    <shortLabel>ve6_hpv03</shortLabel>
                    <fullName>Protein E6</fullName>
                    <alias typeAc="MI:0301" type="gene name">E6</alias>
                </names>
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                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                </interactorType>
                <organism ncbiTaxId="10614">
                    <names>
                        <shortLabel>hpv03</shortLabel>
                        <fullName>Human papillomavirus type 3</fullName>
                    </names>
                </organism>
                <sequence>MAVAMSMDANCPKNIFLLCRNTGIGFDDLRLHCIFCTKQLTTTELQAFALRELNVVWRRGAPYGACARCLLVEGIARRLKYWEYSYYVSGVEEETKQSIDTQQIRCYMCHKPLVKEEKDRHRNEKRRLHKISGHWRGSCQYCWSRCTVRIPR</sequence>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="function" nameAc="MI:0613">Transcriptional transactivator. Binds double stranded DNA</attribute>
                </attributeList>
            </interactor>
            <interactor id="758824">
                <names>
                    <shortLabel>ube3a_human</shortLabel>
                    <fullName>Ubiquitin-protein ligase E3A</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">E6AP ubiquitin-protein ligase</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Oncogenic protein-associated protein E6-AP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Human papillomavirus E6-associated protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Renal carcinoma antigen NY-REN-54</alias>
                    <alias typeAc="MI:0301" type="gene name">UBE3A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">E6AP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EPVE6AP</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HPVE6A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">HECT-type ubiquitin transferase E3A</alias>
                </names>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983168" version="SP_215"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014068" secondary="positive regulation of phosphatidylinositol 3-kinase signaling" version="SP_215"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_570854.1"/>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MEKLHQCYWKSGEPQSDDIEASRMKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="758825">
                <names>
                    <shortLabel>ube3a-e6-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6733648" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7627743" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>758822</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="758826">
                        <names>
                            <shortLabel>ve6_hpv03</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6733653" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P36799" secondary="P36799"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7627753" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>758823</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="758827">
                        <names>
                            <shortLabel>ube3a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6733649" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q05086" secondary="Q05086"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7627750" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>758824</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F1  F2  F3  F4  F5</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
