IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ san_jose-1992-1 Calmodulin inhibits the epidermal growth factor receptor tyrosine kinase. in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot San Jose E., Benguria A., Geller P., Villalobo A. EGFR purified by affinity chromatography Identity of calmodulin taken from manufacturers website. antonio.villalobo@iib.uam.es 2007-06-04. Antonio Villalobo, Instituto de Investigaciones Biomedicas, Universidad Autonoma de Madrid, Spain. J. Biol. Chem. (0021-9258) 1992 Only protein-protein interactions imex curation san_jose-1992-2 Calmodulin inhibits the epidermal growth factor receptor tyrosine kinase. in vitro In vitro protein kinase assay protein kinase assay predetermined predetermined participant predetermined San Jose E., Benguria A., Geller P., Villalobo A. EGFR purified by affinity chromatography antonio.villalobo@iib.uam.es 2007-06-04. Antonio Villalobo, Instituto de Investigaciones Biomedicas, Universidad Autonoma de Madrid, Spain. J. Biol. Chem. (0021-9258) 1992 Only protein-protein interactions imex curation Identity of calmodulin taken from manufacturers website. q9qx70_rat Receptor protein-tyrosine kinase Egfr protein protein rat Rattus norvegicus (Rat) Rat MRPSGTARTKLLLLLAALCAAGGALEEKKVCQGTSNRLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYALAVLSNYGTNKTGLRELPMRNLQEILIGAVRFSNNPILCNMETIQWRDIVQDVFLSNMSMDVQRHLTGCPKCDPSCPNGSCWGRGEENCQKLTKIICAQQCSRRCRGRSPSDCCHNQCAAGCTGPRESDCLVCHRFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGPDYYEVEEDGVSKCKKCDGPCRKVCNGIGIGEFKDTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPENWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKATNHVCNPLCSSEGCWGPEPTDCVSCQNVSRGRECVDKCNILEGEPREFVENSECIQCHPECLPQTMNITCTGRGPDNCIKCAHYVDGPHCVKTCPSGIMGENNTLVWKFADANNVCHLCHANCTYGCAGPGLKGCQQPEGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRQLVRKRTLRRLLQERELVEPLTPSGEAPNQAHLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMEEEDMEDVVDADEYLIPQQGFFNSPSTSRTPLLSSLSANSNSSTVACINRNGSCRVKEDAFLQRYSSDPTSVLTEDNIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLHPAPGRDLHYQNPHSNAVSNPEYLNTAQPTCLSSGFDSSALWIQKGSHQMSLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLRVAPPSSEFSGA calm_bovin Calmodulin CALM CAM protein protein bovin Bos taurus (Bovine) Bovine MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK calm-egfr-1 Binding of EGFR to Calmodulin agarose 650488 N/A 650490 unspecified role unspecified role prey prey rat-liver rattus norvegicus liver Rat liver liver N/A 650491 unspecified role unspecified role bait bait bovin-brain Bos taurus brain brain Brain [cerebrum] physical association physical association false false false Fig. 1, Fig. 2 and Fig. 3 Interaction takes place in the presence of calcium. egfr-1 Autophosphorylation of rat EGFR 650489 N/A 650490 putative self putative self putative self putative self rat-liver rattus norvegicus liver Rat liver liver phosphorylation phosphorylation reaction phosphorylation false true false EGF TGF-alpha