IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ marquart-1999-1 Rapid divergence in the course of Drosophila evolution reveals structural important domains of the Notch antagonist Hairless. yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Marquart J., Alexief-Damianof C., Preiss A., Maier D. Dev. Genes Evol. (0949-944X) 1999 Only protein-protein interactions imex curation suh_drome Suppressor of hairless protein Su(H) dRBP-JK J kappa-recombination signal-binding protein RBP-J kappa CG3497 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MKSYSQFNLNAAAPPAIAYETTVVNPNGSPLDPHQQQQQQSQDMPHFGLPGPQPPSSQQQQQQLQVHHQQQQQQQQQQQQQQHQQQMQMSLLPGPYRPHIEEKKLTRDAMEKYMRERNDMVIVILHAKVAQKSYGNEKRFFCPPPCIYLFGSGWRRRYEEMLQQGEGEQGAQLCAFIGIGSSDQDMQQLDLNGKQYCAAKTLFISDSDKRKHFMLSVKMFYGNGHDIGVFNSKRIKVISKPSKKKQSLKNADLCIASGTNVALFNRLRSQTVSTRYLHVENGHFHASSTQWGAFTIHLLDDNESESEEFQVRDGYIHYGATVKLVCSVTGMALPRLIIRKVDKQMALLEADDPVSQLHKCAFYMKDTDRMYLCLSQEKIIQFQATPCPKEPNKEMINDGACWTIISTDKAEYQFYEGMGPVASPVTPVPIVNSLNLNGGGDVAMLELSGDNFTPHLQVWFGDVEAETMYRCTETLLCVVPEISQFRGEWLWVRQPTQVPISLVRNDGIIYATGLTFTYTPEPGPRPHCNTQAEDVMRARQNNNNNNITSISNNNNSNNAGSPAAGGGLQQQQQQHQALPSISEVQWNSHGSGLS o97169_drohy H hairless protein protein drohy Drosophila hydei (Fruit fly) MTDERNGNDNKSNISTSSKNNSNISPTSIANHSSSNSAGSSSNNERLIAEAAAKFLLKNGINGTNTAAAAAAATLLTAAAAAVTFQLPAAPELKPTTSATAANATNSTTSSSTATSTSNGTTPALSSTKTNSSSNSSSSSLIMATASATALVAGGAGVTAPKAPADVMAGVLDYSALNSPNATKSSKFVGTGNGSSSFDMGRHPISMRSNNSMSGYGGRLQFFKDGKFILELARAKDGDKGGWVSVPRKPFRTPSAATSATVTPTSAVTTTYPKNENSTSLSFSDDNSSIQSSPWQRDQPWKQTRPRRGISKELSLYYQRPRYNVLSQSARQAAMRKRRRPYEPTIATENHQSIFERVSAQENGDETLKAVEVDTKAPEIQSDDIKSETIKEQLTEGKAKSDSKACSSDNKDLNDSSAKAEATLEKMNTSEDEDAMSVTVDDGAPTTSDCLVNGNTSEVNGEPKAHTKCETASEKDTRRTGTPATKTTTMMTDIRLKKQKPRAKLNSIIQKLIDGVPARLEQLSKTPAVAAATASAVASTADRISSNSSGGGAIGSLSHSLAHKVSPPSSAAAASRLVEYHHHHQHVSPRKRILREFEKVSLEDNNGCVNNGSGVGGGISGGAGGKRSRAKGSTATSAVTTKSMPINLAPPQAKVLSTPTPSTTSVATATVATQPTRLNSSYSIHSLLGGSGSSSSKESHDQPAAIISNVHHQHHHSLYASSASYPRSMRNSPNSPEMGGSNGGKSPSHAATKKQRSPPYAAAGSPLPIDYGRRTPPDSYKLAQAHGQQPQHHSFYAPYSGATVSPHIPQAGGGTGTRDLLSPPRSSSASPREPAAASVAVSTPHRTVPKKTASIRREFASPTASNSNSSSTANSCPSPGERSTSSPERRHLQLQRGSPSAVAAAAAGSPLHYYMYPPTQLNGSGTASPHGIAPNATPTTSSTAVAAAAAAAAAAAYIPSVVSPSLYHPYISTLAALRHNPLWVQHYQAGASPLLPPPPPHPHSHPQTSSAAGSRLSPQSPYHPFSYNGVNAAAVAVAAAAAASAFGQPTSNPHLGHPTHPGALAHQNTPPTHLAEHRTHTPKLTDICTDQMSAASSHRTTISSLPAGSSVSVTSAGATQGGGGAGSGSTNSVQSAMFQNSSLRNELSSDLPLNLSKH hles_drome Protein hairless H CG5460 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MALLNDVTSVAECNRQTTMTDEHKSNINSNSSHSSNNNNNGSSSNNDNNSNDDAASSSNSKNNNTSNESSHSNNNTSSIIAEAAAKFLLKNGLNGSSSTSYPPLPPPLPANLSRTTTPTTTTTPSSSSSTASNGFLPHAKTPKSSSIMAASAAVAASVVGATASKPTIDVLGGVLDYSSLGGAATGSLPTTAVVAAAAGTAKIGKGSNSGGSFDMGRTPISTHGNNSWGGYGGRLQFFKDGKFILELARSKDGDKSGWVSVTRKTFRPPSAATSATVTPTSAVTTAYPKNENSTSLSFSDDNSSIQSSPWQRDQPWKQSRPRRGISKELSLFFHRPRNSTLGRAALRTAARKRRRPHEPLTTSEDQQPIFATAIKAENGDDTLKAEAAEAVEIENVAVADTTTNEIKIEKPDTIKGEDDAERLEKEPKKAVSDDSESKEASPGQQVEPQPKDETVDVEMKMNTSEDEEPMTELPRITNAVNGDLNGDLKASIGKPKSKPKPKAKLSSIIQKLIDSVPARLEQMSKTSAVIASTTTSSDRIGGGLSHALTHKVSPPSSATAAGRLVEYHTQHVSPRKRILREFEKVSLEDNGCVNNGSGGASSGGAGGKRSRAKGTSTSSPAGKASPMNLAPPQGKPSPSPGSSSSSTSPATLSTQPTRLNSSYSIHSLLGGSSGSGSSSFSSSGKKCGDHPAAIISNVHHPQHSMYQPSSSSYPRALLTSPKSPDVSGSNGGGGKSPSHTGTKKRSPPYSAGSPVDYGHSFYRDPYAGAGRPSTSGSASQDLSPPRSSPASPATTPRTVPKKTASIRREFASPSASSSSCPSPGDRSASPPERRHMQQQPHLQRSSPLHYYMYPPPPQVNGNGSAGSPTSAPPTSNSSAAAVAAAAAAAAAYIPSPSIYNPYISTLAALRHNPLWMHHYQTGASPLLSPHPQPGGSAAAAAAAAAARLSPQSAYHAFAYNGVGAAVAAAAAAAAFGQPAPSPHTHPHLAHPHQHPHPAALTTHHSPAHLATPKLTDSSTDQMSATSSHRTASTSPSSSSASASSSAATSGASSSAMFHTSSLRNEQSSDLPLNLSKH h-su_h_-1 666893 N/A 666894 unspecified role unspecified role prey prey N/A 666895 unspecified role unspecified role bait bait hairless domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false physical association physical association false false false 5 h-su_h_-2 666893 N/A 666896 unspecified role unspecified role bait bait hairless domain sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false N/A 666894 unspecified role unspecified role prey prey physical association physical association false false false 5