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        <source releaseDate="2013-09-02+01:00">
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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                <names>
                    <shortLabel>katunuma-2006-1</shortLabel>
                    <fullName>A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine.</fullName>
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                            <shortLabel>in vitro</shortLabel>
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                        <shortLabel>fluorescence</shortLabel>
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                        <shortLabel>predetermined</shortLabel>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Katunuma N., Le QT., Murata E., Matsui A., Majima E., Ishimaru N., Hayashi Y., Ohashi A.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">katunuma@tokushima.bunri-u.ac.jp</attribute>
                    <attribute name="journal" nameAc="MI:0885">FEBS Lett. (0014-5793)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="imex-exported">2009-01-08</attribute>
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                    <attribute name="imex curation" nameAc="MI:0959"/>
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                    <shortLabel>casp3_rat</shortLabel>
                    <fullName>Caspase-3</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">Cysteine protease CPP32</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein Yama</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SREBP cleavage activity 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">LICE</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">IRP</alias>
                    <alias typeAc="MI:0301" type="gene name">Casp3</alias>
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                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
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                            <shortLabel>casp3_rat</shortLabel>
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                        <participantIdentificationMethodList>
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                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
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                            </participantIdentificationMethod>
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                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
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                                    <shortLabel>self</shortLabel>
                                    <fullName>self</fullName>
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                                <names>
                                    <shortLabel>purified</shortLabel>
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                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="491681">
                        <names>
                            <shortLabel>casp3_rat</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-2635499" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8547801" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>491678</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
                                    <fullName>nucleotide sequence identification</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">nucleotide sequence</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>self</shortLabel>
                                    <fullName>self</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0503" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383082" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>purified</shortLabel>
                                    <fullName>purified</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0350" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537811" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>cleavage</shortLabel>
                        <fullName>cleavage reaction</fullName>
                        <alias typeAc="MI:1041" type="synonym">cleavage</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0194" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49853" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F3</attribute>
                    <attribute name="kinetics">kd 100 micromolar</attribute>
                    <attribute name="comment" nameAc="MI:0612">lactoferrin enhances the autocatalytic activation</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
