MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint cao-2006a-1 Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. mouse-macrophage Mus musculus macrophage macrophage Macrophage fluorescence imaging fluorescence microscopy fluorescence imaging predetermined predetermined participant predetermined Cao C., Lawrence DA., Li Y., Von Arnim CA., Herz J., Su EJ., Makarova A., Hyman BT., Strickland DK., Zhang L. EMBO J. (0261-4189) 2006 2009-01-08 Only protein-protein interactions imex curation cao-2006a-2 Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. mouse-macrophage Mus musculus macrophage macrophage Macrophage anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Cao C., Lawrence DA., Li Y., Von Arnim CA., Herz J., Su EJ., Makarova A., Hyman BT., Strickland DK., Zhang L. EMBO J. (0261-4189) 2006 2009-01-08 Only protein-protein interactions imex curation lrp1b_mouse Low-density lipoprotein receptor-related protein 1B Lrp1b Lrpdit Low-density lipoprotein receptor-related protein-deleted in tumor protein protein mouse Mus musculus Mouse MSQLLLAILTLSGLLPNAEVLIVGANQDQHLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDQSDESLDTCPEEVEIKCPLNHIACHGSSACVHLSKLCNGVVDCPDGFDEGGHCQELLPSCQQLNCQFKCAMVRNATRCYCEDGFEVAEDGRSCKDQDECSIYGICSQTCKNTYGSYACSCVEGYIMQSDNRSCKVKHEPTDKAPMLLISSLETIELFYINGSKMTTLSSANRNEIHTLDFIYSEEMICWIESRESSNQLKCGQITKAGRLTDQRIINSLQSFQNVEQMAFDWLTRNIYFVDHVSDRIFVCNFNGSVCVTLIESELHNPKAIAADPIAGKLFFTDYGNVPKIERCDLDGMNRTRIVYSKAEQPSALALDLVNRLVYWVDLYLDYVGVVDYQGKNRHTIVQGRQVKHLYGITVFEDYLYATSSDNFNIIRINRFNGTDIHSIIKMESARGIRTYQKRTQPTVRSHACEVDAYGMPGGCSHICLLSSSYKTRTCRCRTGFNMGSDGRSCKRPKNELFLFYGKGRPGIVRGMDLNTKIADECMIPIENLVNPRALDFHAEANYIYFADTTSFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGGMSHPRAIVVDPVNGWMYWTDWKEDKIDDSVGRIEKAWMDGVNRQVFVTSKMLWPNGLTLDFHTSTLYWCDAYYDHIEKVFLNGTHRKVVYSGKELNHPFGLSHHGNYVFWTDYMNGSIFQLDLMTNEVTLLRHERAPLFGLQIYDPRKQQGDNMCRINNGGCGTLCLAIPAGRVCACADNQLLDENGTTCTFNPEEIRFHICKPGEFRCKNKHCIQARWKCDGDDDCLDGSDEDSVTCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQADQFSCGNGRCIPTAWLCDREDDCGDQTDEVASCEFPTCEPLTQFICKSGRCISNKWHCDTDDDCGDRSDEVGCVHSCLDDQFRCSSGRCIPGHWACDGDNDCGDFSDETHINCTKEEARSPAGCIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCRSTGRCINNAWVCDGDVDCEDQSDEEDCDSFLCGPPKYPCANDTSVCLQPEKLCNGRKDCPDGSDEGDLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGHQLKKDNRTCEIVDYCASHLRCSQVCEQQKHMVKCSCYEGWALGTDGESCTSVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLAKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCLINHNRSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDIDNPYVNFITAFTVPDIDDVAVIDFDASEERLYWTDIKTQTITRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHGIDKPQCLAAHPVRGKLYWTDGNTINMANMDGSNSKILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGTCNKRDGRNPSILRNKTSGVVHMKVYDKEAQQGSNSCQVNNGGCSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIESFLMYSVHEGIRGIPLEPRDKVDALMPISGAAFAVGIDFHAENDTIYWTDMGLNKISRAKRDQTWKEDVVTNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGFLFWTEWGQVPCIGKARLDGSEKVMIVSVGITWPNGISIDYEENKLYWCDARSDKIERIDLDTGANREVLLSGSNVDLFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETVTMRTGLGVNLKEIKIFNRVREKGTNVCAKENGGCQQLCLYRGNSRRTCACAHGYLAGDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPVRPYENPNYFKNIIALAFDYNQRREGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSSTSSITRHTVDQTRPGAIDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPSIMRATLTGKNAHVVVSTDILTPNGLTIDHRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDSYIFWSDWGRRAILRSNKYTGGETKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPDGRVNCSCRGDRVLLANNRCVTKNSSCNIYSEFECGNGDCVDYVLTCDGIPHCKDKSDEKLLYCENRSCRSGFKPCYNRRCVPHGKLCDGTNDCGDSSDELDCKVSTCSTVEFRCADGTCIPRSARCNQNMDCSDASDEKGCNNTDCTHFYKLGVKSTGFIRCNSTSLCVLPSWICDGSNDCGDYSDELKCPVQNKHKCEENYFGCPSGRCILNTWVCDGQKDCEDGLDELHCDSSCSWNQFACSVKKCISKHWICDGEDDCGDSLDESDSICGAVTCAADMFSCQGSHACVPQHWLCDGERDCPDGSDELSSAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDEFLQCGYRQCGPEEFRCADGRCLVNTLWQCDGDFDCPDSSDEAPINPRCRSAEHSCNSSFFMCKNGRCIPSDGLCDIRDDCGDGSDETNCHINECLSKKISGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCHCAEGYETQPDNPNGCRSLSDEEPFLILADQHEIRKISTDGSNYTLLKQGLNNVIALDFDYREEFIYWIDSSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYPTVLVSKRLKFPRDLSLDPRAGNLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTIDYVNHRLYWADENHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRVHKTSGADRLSLINSWHAITDIQVYHSYRQPDVSKHLCTVNNGGCSHLCLLGPGKTHTCACPTNFYLAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFKCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLAGQFKCTKNKKCIPVNLRCNGQDDCGDEEDEKDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDNQNDCSDNSDEDNCKPQTCTLKDFLCSNGDCVSSRFWCDGEFDCADGSDEKNCETSCSKDQFQCSNGQCLSAKWKCDGHEDCKYGEDEKNCEPAFPVCSSSEYMCASGGCLSASLKCNGEPDCVDGSDEMDCVIECKEDQFQCKNKAYCIPIRWLCDGIYDCVDGSDEETCGRGGSICRDDEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPPTRPYRCRNDRICLQLEKICNGINDCGDNSDEEHCSGKLSLKSKPCKKDEFTCSNRNCIPMELQCDSLDDCGDGSDEQGCLKTPIEHTCENNGNPCGDDAYCNQIKTSVFCRCKPGFQRNMKGRECADLNECLLFGICSHHCLNTRGSYKCVCDQNFQEKNNSCIAKGSEDQALYIANDTDILGFVYPFNYSGGHQQISHVEHNSRITGMDVHYQRNVIVWSTQFNPGGIFYKMIDAREKRQANSGLICPEFKRPRDIAVDWVAGNVYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVIGDHSHIEEAAMDGTLRRVLVQKNLQRPTGLTVDHFGERIYWADFELSIIGSVLYDGSSPVVSVSSKQGLLHPHRIDVFEDYIYGAGPKNGIFRVQKFGHGSVEVLALGVDKTKSILVSHRYKQLNLPNPCLDLSCDFLCLLNPSGATCICPEGKYMMNGTCHDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGGRCEVNHCSNYCQNGGTCIPSTLGRPTCICALGFTGPNCGKAVCEDSCHNGGSCVVTAGNQPYCHCQADYTGDRCQYYVCHHYCVNSESCTIGNDGSVECVCPTRYEGPKCEIDKCVRCHGGHCIINKDNEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETSIPVCVCSTNWSGTQCERPAPKSSKSEHISTRSIAIIVPLVLLVTLVTTLVIGLVVCKRKRRTKTIRRQPIINGGINVEIGNPSYNMYEVDHDHSDGGLLEPSFMIDPVKSRYIGGGSSAFKLPHTAPPIYLNSDLKGPLTFGPTNYSNPVYAKLYMDGQNCRNSLASVDERKELLPKKIEIGIRETVA mint Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis itb2_mouse Integrin beta-2 Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta Complement receptor C3 subunit beta Itgb2 protein protein mouse Mus musculus Mouse MLGLRPSLLLALAGLFFLGSAVSQECTKYKVSSCRDCIQSGPGCSWCQKLNFTGPGEPDSLRCDTRAQLLLKGCPADDIMDPRSIANPEFDQRGQRKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLNNVKKLGGDLLQALNEITESGRIGFGSFVDKTVLPFVNTHPEKLRNPCPNKEKACQPPFAFRHVLKLTDNSNQFQTEVGKQLISGNLDAPEGGLDAIMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNMYKRSNEFDYPSVGQLAHKLSESNIQPIFAVTKKMVKTYEKLTEIIPKSAVGELSDDSSNVVQLIKNAYYKLSSRVFLDHSTLPDTLKVTYDSFCSNGASSIGKSRGDCDGVQINNPVTFQVKVMASECIQEQSFVIRALGFTDTVTVQVRPQCECQCRDQSREQSLCGGKGVMECGICRCESGYIGKNCECQTQGRSSQELERNCRKDNSSIVCSGLGDCICGQCVCHTSDVPNKEIFGQYCECDNVNCERYNSQVCGGSDRGSCNCGKCSCKPGYEGSACQCQRSTTGCLNARLVECSGRGHCQCNRCICDEGYQPPMCEDCPSCGSHCRDNHTSCAECLKFDKGPFEKNCSVQCAGMTLQTIPLKKKPCKERDSEGCWITYTLQQKDGRNIYNIHVEDSLECVKGPNVAAIVGGTVVGVVLIGVLLLVIWKALTHLTDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES itgb2-lrp1b 372041 lrp1b_mouse 372043 immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell Stoichiometry: 1.0 itb2_mouse 372044 immunostaining immunostaining unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell Stoichiometry: 1.0 colocalization colocalization false false false F6B F6C Addition of RAP or genetic inactivation of PAI-1 or tPA significantly reduced LRP/Mac-1 colocalization in the trailing edges mint lrp1b-itgb2 372042 lrp1b_mouse 372043 monoclonal western monoclonal antibody western blot monoclonal western unspecified role unspecified role bait bait living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 itb2_mouse 372044 monoclonal western monoclonal antibody western blot monoclonal western unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F4D F4E In macrophages obtained from PAI1-/- or tPA-/- mice only small amounts of the LRP/Mac-1 complex could be detected mint