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    <entry>
        <source releaseDate="2005-04-01+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
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            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="174521">
                <names>
                    <shortLabel>al_shamkhan-1996-1</shortLabel>
                    <fullName>OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand.</fullName>
                </names>
                <bibref>
                    <xref>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>spr</shortLabel>
                        <fullName>surface plasmon resonance</fullName>
                        <alias typeAc="MI:0303" type="go synonym">Optical biosensor</alias>
                        <alias typeAc="MI:0303" type="go synonym">BIAcore(r)</alias>
                        <alias typeAc="MI:1041" type="synonym">BIAcore(r)</alias>
                        <alias typeAc="MI:1041" type="synonym">Optical biosensor</alias>
                        <alias typeAc="MI:1041" type="synonym">spr</alias>
                    </names>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">al-Shamkhani A., Birkeland ML., Puklavec M., Brown MH., James W., Barclay AN.</attribute>
                    <attribute name="exp-modification" nameAc="MI:0627">The BIAcore analysis system was used in this experiment</attribute>
                    <attribute name="journal" nameAc="MI:0885">Eur. J. Immunol. (0014-2980)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1996</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="174522">
                <names>
                    <shortLabel>tnfl4_mouse</shortLabel>
                    <fullName>Tumor necrosis factor ligand superfamily member 4</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">OX40 ligand</alias>
                    <alias typeAc="MI:0301" type="gene name">Tnfsf4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ox40l</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Txgp1l</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P43488" version="SP_48" refType="identity" refTypeAc="MI:0356"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2HEW" version="SP_147"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032743" secondary="positive regulation of interleukin-2 production" version="SP_147"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MEGEGVQPLDENLENGSRPRFKWKKTLRLVVSGIKGAGMLLCFIYVCLQLSSSPAKDPPIQRLRGAVTRCEDGQLFISSYKNEYQTMEVQNNSVVIKCDGLYIIYLKGSFFQEVKIDLHFREDHNPISIPMLNDGRRIVFTVVASLAFKDKVYLTVNAPDTLCEHLQINDGELIVVQLTPGYCAPEGSYHSTVNQVPL</sequence>
            </interactor>
            <interactor id="174523">
                <names>
                    <shortLabel>tnr4_rat</shortLabel>
                    <fullName>Tumor necrosis factor receptor superfamily member 4</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">OX40L receptor</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">OX40 antigen</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MRC OX40</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ox40</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Txgp1l</alias>
                    <alias typeAc="MI:0301" type="gene name">Tnfrsf4</alias>
                </names>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10116">
                    <names>
                        <shortLabel>rat</shortLabel>
                        <fullName>Rattus norvegicus (Rat)</fullName>
                        <alias typeAc="MI:1041" type="synonym">Rat</alias>
                    </names>
                </organism>
                <sequence>MYVWVQQPTAFLLLGLSLGVTVKLNCVKDTYPSGHKCCRECQPGHGMVSRCDHTRDTVCHPCEPGFYNEAVNYDTCKQCTQCNHRSGSELKQNCTPTEDTVCQCRPGTQPRQDSSHKLGVDCVPCPPGHFSPGSNQACKPWTNCTLSGKQIRHPASNSLDTVCEDRSLLATLLWETQRTTFRPTTVPSTTVWPRTSQLPSTPTLVAPEGPAFAVILGLGLGLLAPLTVLLALYLLRKAWRSPNTPKPCWGNSFRTPIQEEQTDTHFTLAKI</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="174524">
                <names>
                    <shortLabel>ox40-ox40l</shortLabel>
                    <fullName>The ox40 ligand (ox40L) binds to the ox40 protein.</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-519670" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>174521</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="174525">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-519697" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>174522</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="174526">
                                <names>
                                    <shortLabel>region</shortLabel>
                                    <fullName>extracellular domain</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="interpro" dbAc="MI:0449" id="IPR006052" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-519736" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="51"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="198"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="174527">
                                <names>
                                    <shortLabel>n terminal</shortLabel>
                                    <fullName>sCD4-OX40L was immobilzed to a CD4 mAb (covalently bound)  to the sensor chip</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-519700" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>uncategorized protein modification</shortLabel>
                                        <fullName>uncategorized protein modification</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mod" dbAc="MI:0897" id="MOD:00032" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="18688235" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0179" refType="secondary-ac" refTypeAc="MI:0360"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456692" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>n-term range</shortLabel>
                                                <fullName>n-terminal range</fullName>
                                                <alias typeAc="MI:1041" type="synonym">n-term range</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="36483">
                                <names>
                                    <shortLabel>crisp-kidney</shortLabel>
                                    <fullName>Cricetidae sp.</fullName>
                                </names>
                                <tissue>
                                    <names>
                                        <shortLabel>kidney</shortLabel>
                                        <fullName>kidney [Renal]</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="brenda" dbAc="MI:0864" id="BTO:0000671" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307750" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="IA:0199" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-1349104" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </tissue>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="174528">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-519671" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>174523</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="174529">
                                <names>
                                    <shortLabel>region</shortLabel>
                                    <fullName>soluble form</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="interpro" dbAc="MI:0449" id="IPR001368" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-519702" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="1"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="164"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="36483">
                                <names>
                                    <shortLabel>crisp-kidney</shortLabel>
                                    <fullName>Cricetidae sp.</fullName>
                                </names>
                                <tissue>
                                    <names>
                                        <shortLabel>kidney</shortLabel>
                                        <fullName>kidney [Renal]</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="brenda" dbAc="MI:0864" id="BTO:0000671" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307750" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="IA:0199" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-1349104" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </tissue>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>direct interaction</shortLabel>
                        <fullName>direct interaction</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
