MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url&gt;http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint mart_nez_mo-2005-1 Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor. bovine-baec Bos taurus baec baec anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Martínez-Moreno M., Alvarez-Barrientos A., Roncal F., Albar JP., Gavilanes F., Lamas S., Rodríguez-Crespo I. FEBS Lett. (0014-5793) 2005 2009-01-08 Only protein-protein interactions imex curation martinez-2005-2 Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor. in vitro In vitro affinity chrom affinity chromatography technology Affinity purification Affinity purification affinity chrom predetermined predetermined participant predetermined Martínez-Moreno M., Alvarez-Barrientos A., Roncal F., Albar JP., Gavilanes F., Lamas S., Rodríguez-Crespo I. FEBS Lett. (0014-5793) 2005 2009-01-08 Only protein-protein interactions imex curation martinez-2005-1 Direct interaction between the reductase domain of endothelial nitric oxide synthase and the ryanodine receptor. rat-h9c2 h9c2 rat myoblasts h9c2 h9c2 rat myoblasts imaging technique imaging technique microscopy predetermined predetermined participant predetermined Martínez-Moreno M., Alvarez-Barrientos A., Roncal F., Albar JP., Gavilanes F., Lamas S., Rodríguez-Crespo I. FEBS Lett. (0014-5793) 2005 2009-01-08 Only protein-protein interactions imex curation nos3_bovin Nitric oxide synthase, endothelial NOS3 Endothelial NOS EC-NOS NOS type III Constitutive NOS protein protein bovin Bos taurus (Bovine) Bovine MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPTLTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPPPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPDPWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKAAAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRATILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPGGPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVAVLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGIAPFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFSREPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGPDTPGP mint Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets q7jfy6_equas protein protein donkey Equus asinus VLDVLCSLCVCNGVAVRSNQDLITENLLPGRELLLQTNLINYVT fragmentation type: fragment mint calm_bovin Calmodulin CALM CAM protein protein bovin Bos taurus (Bovine) Bovine MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK nos3-q7jfy6 195439 nos3_bovin 195442 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 q7jfy6_equas 195443 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F2B BIOSOURCE=BAEC cells. <br>For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus mint nos3-q7jfy6-1 195439 q7jfy6_equas 195443 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 nos3_bovin 195442 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F2C For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=HSC2 cells mint q7jfy6-nos3 195439 nos3_bovin 195442 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 q7jfy6_equas 195443 polyclonal western polyclonal antibody western blot polyclonal western unspecified role unspecified role bait bait physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F2B For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=BAEC cells mint nos3-q7jfy6-3 195440 nos3_bovin 195442 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role bait bait purified purified binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 q7jfy6_equas 195443 fingerprinting peptide massfingerprinting fingerprinting unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F1 For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus mint nos3-calm-3 195440 nos3_bovin 195442 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role bait bait purified purified tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false Stoichiometry: 1.0 calm_bovin 195444 fingerprinting peptide massfingerprinting fingerprinting unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 physical association physical association false false false F1 mint nos3-q7jfy6-2 195441 nos3_bovin 195442 experimental particp experimental participant identification experimental particp unspecified role unspecified role unspecified role unspecified role physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 q7jfy6_equas 195443 experimental particp experimental participant identification experimental particp unspecified role unspecified role unspecified role unspecified role physiological level physiological level endogenous level endogenous endogenous endogenous level Stoichiometry: 1.0 colocalization colocalization false false false F4 For the RyR recepetor was used the donkey UP_ID since is not available for Bos taurus<br>BIOSOURCE=H9C2 cells mint