MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint nunes-2005-1 The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 fluorescence imaging fluorescence microscopy fluorescence imaging predetermined predetermined participant predetermined Nunes SM., Ferralli J., Choi K., Brown-Luedi M., Minet AD., Chiquet-Ehrismann R. Exp. Cell Res. (0014-4827) 2005 nunes-2005-4 The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. yeast Saccharomyces cerevisiae Baker's yeast two hybrid pooling two hybrid pooling approach two hybrid pooling predetermined predetermined participant predetermined Nunes SM., Ferralli J., Choi K., Brown-Luedi M., Minet AD., Chiquet-Ehrismann R. Exp. Cell Res. (0014-4827) 2005 nunes-2005-2 The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Nunes SM., Ferralli J., Choi K., Brown-Luedi M., Minet AD., Chiquet-Ehrismann R. Exp. Cell Res. (0014-4827) 2005 nunes-2005-3 The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix. chlae-cos_7 Cercopithecus aethiops simian cells transformed with SV40 Grivet cos_7 cercopithecus aethiops, by transformation with SV40 anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Nunes SM., Ferralli J., Choi K., Brown-Luedi M., Minet AD., Chiquet-Ehrismann R. Exp. Cell Res. (0014-4827) 2005 ten1_chick Teneurin-1 TENM1 ODZ1 Protein Odd Oz/ten-m homolog 1 TNM1 Tenascin-M1 Teneurin transmembrane protein 1 protein protein chick Gallus gallus (Chicken) Chicken MEQMDCKPYQPLSKVKHEVDLTYTSSSDESEDGRKQRQSYDSRETLNEYSQELRLNYNSQSRKRKNTDQSTQDMEFCETPHILCSGYQTDLHGVSEHSYPLEVGSDVDTETEGGASPDHALRMWMRGMKSEHSSCLSSRANSALSLTDTDHERKSDGENDMPGSPHNQFTFRPLPPPPPPPHACTCTRKPPPAADSLQRRSMTTRSQPSPAAPTPPTSTQDSVHLHNSWVLNSNIPLETRHFLFKHGSGSSAIFSAASQNYPLTSNTVYSPPPRPLPRNTFSRPAFTFSKPYRCCNWKCTALSATAITVTLALLLAYVIAVHLFGLTWQLQPVEGQLYENGVSKGNKGAESTDTTYSPIGGKVSDKTEKKVFQKGRAIDTGEVEIGAQVMQTIPPGLFWRFQITIHHPVYLKFNISLAKDSLLGIYGRRNIPPTHTQFDFVKLMDGKQLIKQEPKNSEEPQQAPRNLILTSLQETGFIEYMDQGAWHMAFYNDGKKVEQVFVLTTAIEVLDDCSTNCNGNGECISGHCHCFPGFLGPDCAKDSCPVLCSGNGEYEKGHCVCRNGWKGPECDVPEEQCIDPTCFGHGTCIMGVCICVPGYKGEICEEEDCLDPMCSGHGVCVQGECHCSAGWGGVNCETSLPICQEHCSGHGTFLLDVGLCSCEPQWTGSDCSTELCTLDCGSHGVCSRGICQCEEGWVGPTCEERTCHSHCAEHGQCKDGKCECSPGWEGDHCTIDGCPGLCYGNGRCTLDQNGWHCVCQVGWSGSGCNVVMEMACGDNLDNDGDGLTDCVDPDCCQQNNCYASPLCQGSPDPLDLIQHSQPPFSQHPPRLFYDRIRFLIGKESTHVIPGDISFESRRASVIRGQVVAIDGTPLVGVNVSFLHHDEYGYTISRQDGSFDLVAVGGISVTLVFDRSPFISEKRTLWLSWNRFVIVDKVVMQRAESDIPSCDVSSFISPNPIVLPSPLTAFGGSCPERGTVIPELQVVQEEIPIPSSFVKLSYLSSRTPGYKTLLRVILTHTTIPSGMTKVHLIIAVEGRLLQKWFPAAANLVYTFAWNKTDIYGQKVSGLAEAMVSVGYEYETCPDFILWEKRTVILQGFEMDASNLGGWSINKHHVLNPQSGIVHKGNGENMFISQQPPVISTMMGNGHQRSVSCSNCNGLALNSKLFAPVALTSGPDGSVYIGDFNFVRRIFPSGNSIGILELRNRDTRHSTSPAHKYYLAVDPVSESLYLSDTNTRRVYKAKSLIETKDLAKNVDVVAGTGDQCLPFDQSHCGDGGKASEASLNSPRGITIDKHGFIYFVDGTMIRKIDENGMITTIIGSNGLTSTQPLSCDSGMDITQVRLEWPTDLTVNPLDNSLYVLDNNIVLQISESRRVRIIAGRPIHCQVPGIDHFIVSKVAIHSTLESARAIAVSHSGIPYIRETDERKINRIQQVTTNGEISIIAGAPSDCDCKIDPNCDCFSGDGGYAKDAKLKAPSSLAVSPDDTLYVADLGNIRIRAVSRNKAHLSDTNMYEIASPADQELYQFTINGTHLHTLNLITRDYIYNFTYSGEGDVATITSSNGNSVHIRRDTSGLPLWVVVPGGQVYWLTISSNGVLKRVYAQGYNLALMTYPGNTGLLATKSDENGWTTVYEYDSDGHLTNATFPTGEVSSFHSDVEKLTRVELDTSNRENMVTATNFSATSTIYTLKQDNTQNIYRVSPDGSLRVTFASGMEITLNTEPHILAGVVSPTLGKCNISLPGEHNSNLIEWRQRREQTKGNISTFERRLRAHNRNLLSIDFDHVTRTGKIYDDHRKFTLRIMYDQTGRPVLWSPISKYNEVNITYSHSGLVTYIQRGTWTEKMEYDPSGNIISRTWADGKIWSYTYLEKSVMLLLHSQRRYIFEYDQSDYLLSVTMPSMVRHALQTMLSVGYYRNIYTPPDSGAAFIQDVTRDGRLLQTLYPGTGRRVLYKYSKQSRLSEILYDTTQVTFTYEESSGVIKTIHLMHDGFICTIRYRQTGPLIGRQIFRFSEEGLVNARFDYSYNNFRVTSMQAMINETPLPIDLYRYVDVSGRTEQFGKFSVINYDLNQVITTTVMKHTKIFSANGQVIEVQYEILKSIAYWMTIQYDNMGRMVICDIRVGVDANITRYFYEYDRDGQLQTVSVNDKTQWRYSYDLNGNINLLSHGNSARLTPLRYDLRDRITRLGEIQYKMDEDGFLRQRGNEIFEYNSNGLLNKAYNKVSGWTVQYCYDGLGRRVASKSSLGQHLQFFYADLSNPIRVTHLYNHSSSEITSLYYDLQGHLIAMELSSGEEYYVACDNTGTPLAVFSSRGQVIKEILYTPYGEIYQDTNPDFQVVIGFHGGLYDSLTKLVHLGQRDYDVIAGRWTTPNHHIWKHLNAVPQPFNLYSFENNYPVGRIQDVAKYTTDIGSWLELFGFQLHNVLPGFPKPEIEALETTYELLQLQTKTQEWDPGKTILGIQCELQKQLRNFISLDQLPMTPRYSDGKCYEGVKQPRFAAIPSVFGKGIKFAIKDGIVTADIIGVANEDSRRIAAILNNAHYLENLHFTIEGRDTHYFIKLGSLEEDLSLIGNTGGRRILENGVNVTVSQMTSVINGRTRRFADIQLQHGALCFNVRYGTTVEEEKNHVLEVARQRAVAQAWTKEQRRLQEGEEGIRAWTDGEKQQLLNTGRVQGYDGYFVLSVEQYLELSDSANNIHFMRQSEIGRR mint May function as a cellular signal transducer srbs1_mouse Sorbin and SH3 domain-containing protein 1 Sorbs1 Kiaa1296 Sh3d5 Ponsin c-Cbl-associated protein SH3 domain protein 5 SH3P12 protein protein mouse Mus musculus Mouse MSSECDVGSSKAVVNGLASGNHGPDKDMDPTKICTGKGTVTLRASSSYRGTPSSSPVSPQESPKHESKSGLEPEDPSADEWKLSSSADTNGNAQPSPLAAKGYRSVHPSLSADKPQGSPLLNEVSSSHIETDSQDFPPTSRPSSAYPSTTIVNPTIVLLQHNRDPASERRAGEQDPVPTPAELTSPGRASERRAKDASRRVVRSAQDLSDVSTDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDVHSPRYSFSDDTKSPLSVPRSKSEMNYIEGEKVVKRSATLPLPARSSSLKSSPERNDWEPLDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGRPTNLEKDLSFCQAELEADLEKVETVNKSPSANSPQSSAVSPTPDITSEPPGYIYSSNFHAVKRESDGTPGGLASLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKVDRKGGNAHMISSSSVHSRTFHTSNALGPGCKHKKPLSAAKACISEILPSKFKPRLSAPSALLQEQKSVLLPSEKAQSCENLCVSLNDSKRGLPLRVGGSIENLLMRSRRDYDSKSSSTMSLQEYGTSSRRPCPLSRKAGLHFSMFYRDMHQINRAGLSLGSISSSSVRDLASHFERSSLTLARGELGASQEGSEHIPKHTVSSRITAFEQLIQRSRSMPSLDFSGRLSKSPTPVLSRSGLTSARSAESLLESTKLRPREMDGMDSGGVYASPTCSNMADHALSFRSLVPSEPLSICSDELDHCSNVSNDSREGSGGSVHGDFPKHRLNKCKGTCPASYTRFTTIRKHEQQSSRQSDWRSDSRGDKNSLLRNIHLMSPLPFRLKKPLQQHPRQPPPSDSSESPAGQKADLPCHDPQDQPHSAGKPQVPTRLSSRHTMARLSHNSEPPLDRPAGLEDCTRAINNGNPVPYSDHGLDRNNNPQSELAAAHGDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGLEMRPARAKFDFKAQTLKELPLQKGDVVYIYRQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPRKLAPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVLKRPLVKTPVDYIDLPYSSSPSRSATVSPQQPQAQQRRVTPDRSQPSLDLCSYQALYSYVPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTRQFGTFPGNYVKPLYL mbd1_mouse Methyl-CpG-binding domain protein 1 Mbd1 Methyl-CpG-binding protein MBD1 protein protein mouse Mus musculus Mouse MAESWQDCPALGPGWKRRESFRKSGASFGRSDIYYQSPTGEKIRSKVELTRYLGPACDLTLFDFRQGTLCHPIPKTHPLAVPSKKKKKPSKPAKTKKQQVGLQRSEVRIETPQGEYKAPTATALASLSVSASASSSASASASASSHAPVCCENCGIHFSWDGVKRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGDCAACLVKEDCGVCSTCRLQLPSDVASGLYCKCERRRCLRIMEKSRGCGVCRGCQTQEDCGHCCICLRSPRPGLKRQWRCLQRRCFWGKRDSSKRGSKVASQRHSQAPPLPPHPASQYTEPTELHISDIAPTSPAEFIYYCVDEDEDELQPYTNQRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGGNQKRQKCRWRQCLQFAMKRLLPSAGSGSGEGAGLRPYQTHQTHQKRPASARQLQLSSPLKAPWAVVTAPPGPVRDSRKQQAGRGSVLPQPDTDFVFLQEGTSSAMQMPGTAAASTEVPVQAAQCSAPSWVVALPQVKQETADAPEEWTAVTTFLTSSTLQSGFPSKAADPDLSPVKQEPPGPEEDGEEKKDDVSETTPAEEIGGVGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNEKEYFTELQLKEEVL mint Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters sorbs1-tenm1 209070 ten1_chick 209074 immunostaining immunostaining unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 srbs1_mouse 209075 immunostaining immunostaining unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 colocalization colocalization false false false F3G mint mbd1-tenm1 209070 mbd1_mouse 209076 immunostaining immunostaining unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 ten1_chick 209074 immunostaining immunostaining unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 colocalization colocalization false false false F5I homomint mint tenm1-sorbs1-1 209071 ten1_chick 209074 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 srbs1_mouse 209075 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role prey prey over-expressed over expressed level over-expressed binding site binding region binding-associated region binding region full dna sequence full identification by DNA sequencing full dna sequence certain certain sequence position certain certain certain sequence position certain false tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 physical association physical association false false false F2 mint tenm1-mbd1 209071 mbd1_mouse 209076 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role prey prey over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 ten1_chick 209074 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 physical association physical association false false false F4A homomint mint mbd1-tenm1-1 209072 mbd1_mouse 209076 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 ten1_chick 209074 western blot western blot Immuno blot Immuno blot unspecified role unspecified role unspecified role unspecified role over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 colocalization colocalization false false false F4B homomint mint tenm1-sorbs1 209073 ten1_chick 209074 western blot western blot Immuno blot Immuno blot unspecified role unspecified role bait bait over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false binding site binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false intracellular domain Stoichiometry: 1.0 srbs1_mouse 209075 nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence unspecified role unspecified role prey prey over-expressed over expressed level over-expressed tagged molecule tag tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false Stoichiometry: 1.0 physical association physical association false false false F3H mint