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<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2004-05-01+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="105460">
                <names>
                    <shortLabel>van_de_veld-1991-1</shortLabel>
                    <fullName>The B-cell surface protein CD72/Lyb-2 is the ligand for CD5.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="1711157" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-307922" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-1">
                        <names>
                            <shortLabel>in vitro</shortLabel>
                            <fullName>In vitro</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>facs</shortLabel>
                        <fullName>fluorescence-activated cell sorting</fullName>
                        <alias typeAc="MI:0303" type="go synonym">FACS</alias>
                        <alias typeAc="MI:0303" type="go synonym">Flow cytometry</alias>
                        <alias typeAc="MI:1041" type="synonym">facs</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0054" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1125" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="11988464" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Van de Velde H., von Hoegen I., Luo W., Parnes JR., Thielemans K.</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature (0028-0836)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1991</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="105461">
                <names>
                    <shortLabel>cd72_human</shortLabel>
                    <fullName>B-cell differentiation antigen CD72</fullName>
                    <alias typeAc="MI:0301" type="gene name">CD72</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Lyb-2</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P21854" version="SP_75" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016187" version="SP_186"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030246" secondary="carbohydrate binding" version="SP_186"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001304" version="SP_186"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039689" version="SP_186"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_186"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_186"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_186"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016186" version="SP_186"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000259633" version="SP_186" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-416700" version="SP_186"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307924" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000137101" version="SP_186" refType="gene"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000259633" version="SP_186" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004888" secondary="transmembrane signaling receptor activity" version="SP_186"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001773.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007155" secondary="cell adhesion" version="SP_186"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD</sequence>
            </interactor>
            <interactor id="105462">
                <names>
                    <shortLabel>cd5_human</shortLabel>
                    <fullName>T-cell surface glycoprotein CD5</fullName>
                    <alias typeAc="MI:0301" type="gene name">CD5</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">LEU1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Lymphocyte antigen T1/Leu-1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P06127" version="SP_80" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A0N0P4" version="SP_99" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031295" secondary="T cell costimulation" version="SP_198"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307931" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001333385.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000347785" version="SP_198" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038023" secondary="signaling receptor activity" version="SP_198"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036772" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2JA4" version="SP_198"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003566" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005044" secondary="scavenger receptor activity" version="SP_198"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001190" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2JOP" version="SP_198"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000110448" version="SP_198" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2JP0" version="SP_198"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-21N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000342681" version="SP_198" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" secondary="integral component of plasma membrane" version="SP_198"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017448" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097190" secondary="apoptotic signaling pathway" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" secondary="external side of plasma membrane" version="SP_198"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K9I3" version="SP_103" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008037" secondary="cell recognition" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2OTT" version="SP_198"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_055022.2"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MPMGSLQPLATLYLLGMLVASCLGRLSWYDPDFQARLTRSNSKCQGQLEVYLKDGWHMVCSQSWGRSSKQWEDPSQASKVCQRLNCGVPLSLGPFLVTYTPQSSIICYGQLGSFSNCSHSRNDMCHSLGLTCLEPQKTTPPTTRPPPTTTPEPTAPPRLQLVAQSGGQHCAGVVEFYSGSLGGTISYEAQDKTQDLENFLCNNLQCGSFLKHLPETEAGRAQDPGEPREHQPLPIQWKIQNSSCTSLEHCFRKIKPQKSGRVLALLCSGFQPKVQSRLVGGSSICEGTVEVRQGAQWAALCDSSSARSSLRWEEVCREQQCGSVNSYRVLDAGDPTSRGLFCPHQKLSQCHELWERNSYCKKVFVTCQDPNPAGLAAGTVASIILALVLLVVLLVVCGPLAYKKLVKKFRQKKQRQWIGPTGMNQNMSFHRNHTATVRSHAENPTASHVDNEYSQPPRNSHLSAYPALEGALHRSSMQPDNSSDSDYDLHGAQRL</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="105463">
                <names>
                    <shortLabel>cd5-cd72-1</shortLabel>
                    <fullName>Interaction detected by FACS</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-307941" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>105460</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="105464">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-307942" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>105461</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="10090">
                                <names>
                                    <shortLabel>mouse-l cells</shortLabel>
                                    <fullName>Mus musculus embryo fibroblast, Moloney Sarcoma Virus transformed</fullName>
                                </names>
                                <cellType>
                                    <names>
                                        <shortLabel>l cells</shortLabel>
                                        <fullName>Mouse embryo fibroblast, Moloney Sarcoma Virus transformed</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="intact" dbAc="MI:0469" id="IA:0068" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307782" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="cabri" dbAc="MI:0246" id="ECACC 90110101" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="mint" dbAc="MI:0471" id="MINT-113218" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </cellType>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                    <participant id="105465">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-307943" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>105462</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <hostOrganismList>
                            <hostOrganism ncbiTaxId="9606">
                                <names>
                                    <shortLabel>human-ccrf_cem</shortLabel>
                                    <fullName>Homo sapiens T-Acute Lymphoblastic Leukemia cell line</fullName>
                                </names>
                                <cellType>
                                    <names>
                                        <shortLabel>ccrf_cem</shortLabel>
                                        <fullName>T-Acute Lymphoblastic Leukemia cell line</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="intact" dbAc="MI:0469" id="IA:0069" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307787" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="cabri" dbAc="MI:0246" id="ACC 240" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </cellType>
                            </hostOrganism>
                        </hostOrganismList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
