IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ raijmakers-2002-1 Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. chlae-cos_1 Chlorocebus aethiops COS-1 cells Grivet cos_1 CV-1 Simian cells (cercopithecus aethiops) transformed by SV40 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Raijmakers R., Egberts WV., van Venrooij WJ., Pruijn GJ. g.pruijn@ncmls.kun.nl J. Mol. Biol. (0022-2836) 2002 exos2_human Exosome complex component RRP4 EXOSC2 RRP4 Ribosomal RNA-processing protein 4 Exosome component 2 protein protein human Homo sapiens Human MAMEMRLPVARKPLSERLGRDTKKHLVVPGDTITTDTGFMRGHGTYMGEEKLIASVAGSVERVNKLICVKALKTRYIGEVGDIVVGRITEVQQKRWKVETNSRLDSVLLLSSMNLPGGELRRRSAEDELAMRGFLQEGDLISAEVQAVFSDGAVSLHTRSLKYGKLGQGVLVQVSPSLVKRQKTHFHDLPCGASVILGNNGFIWIYPTPEHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQRMMLYDTSILYCYEASLPHQIKDILKPEIMEEIVMETRQRLLEQEG exos4_human Exosome complex component RRP41 EXOSC4 RRP41 SKI6 Ribosomal RNA-processing protein 41 Exosome component 4 p12A protein protein human Homo sapiens Human MAGLELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRARALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGFVDGTALADLSHVEEAAGGPQLALALLPASGQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHVREASILLGD exos7_human Exosome complex component RRP42 KIAA0116 RRP42 EXOSC7 Ribosomal RNA-processing protein 42 Exosome component 7 p8 protein protein human Homo sapiens Human MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFDAISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG exos3_human Exosome complex component RRP40 EXOSC3 RRP40 CGI-102 Ribosomal RNA-processing protein 40 Exosome component 3 p10 protein protein human Homo sapiens Human MAEPASVAAESLAGSRARAARTVLGQVVLPGEELLLPEQEDAEGPGGAVERPLSLNARACSRVRVVCGPGLRRCGDRLLVTKCGRLRHKEPGSGSGGGVYWVDSQQKRYVPVKGDHVIGIVTAKSGDIFKVDVGGSEPASLSYLSFEGATKRNRPNVQVGDLIYGQFVVANKDMEPEMVCIDSCGRANGMGVIGQDGLLFKVTLGLIRKLLAPDCEIIQEVGKLYPLEIVFGMNGRIWVKAKTIQQTLILANILEACEHMTSDQRKQIFSRLAES exos5_human Exosome complex component RRP46 EXOSC5 CML28 RRP46 Ribosomal RNA-processing protein 46 Exosome component 5 p12B Chronic myelogenous leukemia tumor antigen 28 protein protein human Homo sapiens Human MEEETHTDAKIRAENGTGSSPRGPGCSLRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEKSRERLIRNTCEAVVLGTLHPRTSITVVLQVVSDAGSLLACCLNAACMALVDAGVPMRALFCGVACALDSDGTLVLDPTSKQEKEARAVLTFALDSVERKLLMSSTKGLYSDTELQQCLAAAQAASQHVFRFYRESLQRRYSKS exos1_human Exosome complex component CSL4 CSL4 EXOSC1 CGI-108 Exosome component 1 protein protein human Homo sapiens Human MAPPVRYCIPGERLCNLEEGSPGSGTYTRHGYIFSSLAGCLMKSSENGALPVVSVVRETESQLLPDVGAIVTCKVSSINSRFAKVHILYVGSMPLKNSFRGTIRKEDVRATEKDKVEIYKSFRPGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHSESGIQMVPISWCEMQCPKTHTKEFRKVARVQPEFLQT exos8_human Exosome complex component RRP43 OIP2 RRP43 EXOSC8 Ribosomal RNA-processing protein 43 Exosome component 8 p9 Opa-interacting protein 2 protein protein human Homo sapiens Human MAAGFKTVEPLEYYRRFLKENCRPDGRELGEFRTTTVNIGSISTADGSALVKLGNTTVICGVKAEFAAPSTDAPDKGYVVPNVDLPPLCSSRFRSGPPGEEAQVASQFIADVIENSQIIQKEDLCISPGKLVWVLYCDLICLDYDGNILDACTFALLAALKNVQLPEVTINEETALAEVNLKKKSYLNIRTHPVATSFAVFDDTLLIVDPTGEEEHLATGTLTIVMDEEGKLCCLHKPGGSGLTGAKLQDCMSRAVTRHKEVKKLMDEVIKSMKPK mtmr3_human Myotubularin-related protein 3 MTMR3 FYVE domain-containing dual specificity protein phosphatase 1 Zinc finger FYVE domain-containing protein 10 KIAA0371 ZFYVE10 Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Phosphatidylinositol-3-phosphate phosphatase protein protein human Homo sapiens Human MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN rrp4-rrp41-1 Interaction between RRP4 and RRP41 identified by Y2H 134376 N/A 134377 unspecified role unspecified role bait bait N/A 134378 unspecified role unspecified role prey prey physical association physical association false false false rrp4-rrp41-2 Interaction between RRP4 and RRP41 identified by Y2H 134376 N/A 134378 unspecified role unspecified role bait bait N/A 134377 unspecified role unspecified role prey prey physical association physical association false false false rrp4-rrp42-1 Interaction between RRP4 and RRP42 identified by Y2H 134376 N/A 134377 unspecified role unspecified role bait bait N/A 134379 unspecified role unspecified role prey prey physical association physical association false false false rrp4-rrp42-2 Interaction between RRP4 and RRP42 identified by Y2H 134376 N/A 134379 unspecified role unspecified role bait bait N/A 134377 unspecified role unspecified role prey prey physical association physical association false false false rrp41-rrp42-1 Interaction between RRP41 and RRP42 identified by Y2H 134376 N/A 134378 unspecified role unspecified role bait bait N/A 134379 unspecified role unspecified role prey prey physical association physical association false false false Arbitary assigment made of bait/roles since not defined by author - only that interaction seen in one direction only. rrp40-rrp46-1 Interaction between RRP40 and RRP46 identified by Y2H 134376 N/A 134380 unspecified role unspecified role bait bait N/A 134381 unspecified role unspecified role prey prey physical association physical association false false false Arbitary assigment made of bait/roles since not defined by author - only that interaction seen in one direction only. rrp42-csl4-1 Interaction between RRP42 and CSL4 identified by Y2H 134376 N/A 134379 unspecified role unspecified role bait bait N/A 134382 unspecified role unspecified role prey prey physical association physical association false false false rrp42-csl4-2 Interaction between RRP42 and CSL4 identified by Y2H 134376 N/A 134382 unspecified role unspecified role bait bait N/A 134379 unspecified role unspecified role prey prey physical association physical association false false false rrp46-csl4-1 Interaction between RRP46 and CSL4 identified by Y2H 134376 N/A 134381 unspecified role unspecified role bait bait N/A 134382 unspecified role unspecified role prey prey physical association physical association false false false rrp46-csl4-2 Interaction between RRP46 and CSL4 identified by Y2H 134376 N/A 134382 unspecified role unspecified role bait bait N/A 134381 unspecified role unspecified role prey prey physical association physical association false false false rrp46-oip2-1 Interaction between RRP46 and OIP2 identified by Y2H 134376 N/A 134381 unspecified role unspecified role bait bait N/A 134383 unspecified role unspecified role prey prey physical association physical association false false false rrp46-op2-2 Interaction between RRP46 and OIP2 identified by Y2H 134376 N/A 134383 unspecified role unspecified role bait bait N/A 134381 unspecified role unspecified role prey prey physical association physical association false false false rrp42-mtr3-1 Interaction between RRP42 and MTR3 identified by Y2H 134376 N/A 134384 unspecified role unspecified role prey prey N/A 134379 unspecified role unspecified role bait bait physical association physical association false false false rrp42-mtr3-2 Interaction between RRP42 and MTR3 identified by Y2H 134376 N/A 134384 unspecified role unspecified role bait bait N/A 134379 unspecified role unspecified role prey prey physical association physical association false false false csl4-mtr3-1 Interaction between CSL4 and MTR3 identified by Y2H 134376 N/A 134382 unspecified role unspecified role bait bait N/A 134384 unspecified role unspecified role prey prey physical association physical association false false false csl4-mtr3-2 Interaction between CSL4 and MTR3 identified by Y2H 134376 N/A 134384 unspecified role unspecified role bait bait N/A 134382 unspecified role unspecified role prey prey physical association physical association false false false oip2-mtr3-1 Interaction between OIP2 and MTR3 identified by Y2H 134376 N/A 134383 unspecified role unspecified role bait bait N/A 134384 unspecified role unspecified role prey prey physical association physical association false false false oip2-mtr3-2 Interaction between OIP2 and MTR3 identified by Y2H 134376 N/A 134384 unspecified role unspecified role bait bait N/A 134383 unspecified role unspecified role prey prey physical association physical association false false false