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    <entry>
        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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                <names>
                    <shortLabel>deng-2000-1</shortLabel>
                    <fullName>Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.</fullName>
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                            <shortLabel>in vivo</shortLabel>
                            <fullName>in vivo</fullName>
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                <interactionDetectionMethod>
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                        <shortLabel>ms of complexes</shortLabel>
                        <fullName>mass spectrometry studies of complexes</fullName>
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                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., Chen ZJ.</attribute>
                    <attribute name="journal" nameAc="MI:0885">Cell (0092-8674)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2000</attribute>
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                    <shortLabel>ub2v1_human</shortLabel>
                    <fullName>Ubiquitin-conjugating enzyme E2 variant 1</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">TRAF6-regulated IKK activator 1 beta Uev1A</alias>
                    <alias typeAc="MI:0306" type="orf name">P/OKcl.19</alias>
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                    <alias typeAc="MI:0302" type="gene name synonym">UBE2V</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">UEV1</alias>
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                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
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                <sequence>MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN</sequence>
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                    <alias typeAc="MI:0301" type="gene name">UBE2N</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">BLU</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">UbcH13</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">E2 ubiquitin-conjugating enzyme N</alias>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000724" secondary="double-strand break repair via homologous recombination" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5607764" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006511" secondary="ubiquitin-dependent protein catabolic process" version="SP_198"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003339.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DHJ" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9646399" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3HCU" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EYA" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-168638" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016574" secondary="histone ubiquitination" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ONN" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69473" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ORH" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4WHV" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051443" secondary="positive regulation of ubiquitin-protein transferase activity" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020702" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4TKP" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6KL4" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UMS" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VON" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4IP3" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004842" secondary="ubiquitin-protein transferase activity" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JKY" version="SP_198"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000729" secondary="DNA double-strand break processing" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AIU" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ONL" version="SP_198"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000318066" version="SP_198" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P5B" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450302" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="7BBD" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-937041" version="SP_198"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6S53" version="SP_198"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169408" version="SP_198"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016135" version="SP_198"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKTNEAQAIETARAWTRLYAMNNI</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="142755">
                <names>
                    <shortLabel>ube2n-ube2v1-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-50197" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7427166" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>142752</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="142756">
                        <names>
                            <shortLabel>ub2v1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-433279" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7427174" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>142753</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>fingerprinting</shortLabel>
                                    <fullName>peptide massfingerprinting</fullName>
                                    <alias typeAc="MI:1041" type="synonym">fingerprinting</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0082" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="11752590" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-70" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="10967324" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="11805826" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="142757">
                        <names>
                            <shortLabel>ube2n_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-433274" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7427171" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>142754</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>fingerprinting</shortLabel>
                                    <fullName>peptide massfingerprinting</fullName>
                                    <alias typeAc="MI:1041" type="synonym">fingerprinting</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0082" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="11752590" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-70" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="10967324" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="11805826" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>unspecified role</shortLabel>
                                    <fullName>unspecified role</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">- 160.80.34.231</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
