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    <entry>
        <source releaseDate="2004-02-01Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="16606">
                <names>
                    <shortLabel>song-1997-1</shortLabel>
                    <fullName>The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="9070862" refType="primary-reference" refTypeAc="MI:0358"/>
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                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-80342" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="4932">
                        <names>
                            <shortLabel>yeasx</shortLabel>
                            <fullName>Saccharomyces cerevisiae (Baker's yeast)</fullName>
                            <alias typeAc="MI:1041" type="synonym">Baker's yeast</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>2 hybrid</shortLabel>
                        <fullName>two hybrid</fullName>
                        <alias typeAc="MI:0303" type="go synonym">2H</alias>
                        <alias typeAc="MI:0303" type="go synonym">2h</alias>
                        <alias typeAc="MI:0303" type="go synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:0303" type="go synonym">two-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">2-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2H</alias>
                        <alias typeAc="MI:1041" type="synonym">two-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:1041" type="synonym">2h</alias>
                        <alias typeAc="MI:1041" type="synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Y2H</alias>
                        <alias typeAc="MI:1041" type="synonym">Y-2H</alias>
                        <alias typeAc="MI:1041" type="synonym">2 hybrid</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0018" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-94" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="12634794" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="1946372" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="10967325" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Song WJ., Chung SH., Kurnit DM.</attribute>
                    <attribute name="journal" nameAc="MI:0885">Biochem. Biophys. Res. Commun. (0006-291X)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1997</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="16607">
                <names>
                    <shortLabel>dyr1a_mouse</shortLabel>
                    <fullName>Dual specificity tyrosine-phosphorylation-regulated kinase 1A</fullName>
                    <alias typeAc="MI:0301" type="gene name">Dyrk1a</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Dyrk</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Protein kinase minibrain homolog</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MP86</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Dual specificity YAK1-related kinase</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q61214" version="SP_70" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003779" secondary="actin binding" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048156" secondary="tau protein binding" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005856" secondary="cytoskeleton" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990904" secondary="ribonucleoprotein complex" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000381" secondary="regulation of alternative mRNA splicing, via spliceosome" version="SP_191"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-80344" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000023614" version="SP_191" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004712" secondary="protein serine/threonine/tyrosine kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_191"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043518" secondary="negative regulation of DNA damage response, signal transduction by p53 class mediator" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030425" secondary="dendrite" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0038083" secondary="peptidyl-tyrosine autophosphorylation" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031115" secondary="negative regulation of microtubule polymerization" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004715" secondary="non-membrane spanning protein tyrosine kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034205" secondary="amyloid-beta formation" version="SP_191"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-1538133" version="SP_191"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003713" secondary="transcription coactivator activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008092" secondary="cytoskeletal protein binding" version="SP_191"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR028318" version="SP_191"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001106860.1"/>
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                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_031916.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033120" secondary="positive regulation of RNA splicing" version="SP_191"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSG00000022897" version="SP_191" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016607" secondary="nuclear speck" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004713" secondary="protein tyrosine kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004672" secondary="protein kinase activity" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015631" secondary="tubulin binding" version="SP_191"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011244396.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018107" secondary="peptidyl-threonine phosphorylation" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007623" secondary="circadian rhythm" version="SP_191"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000113660" version="SP_191" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043621" secondary="protein self-association" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_191"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR044131" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090312" secondary="positive regulation of protein deacetylation" version="SP_191"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048025" secondary="negative regulation of mRNA splicing, via spliceosome" version="SP_191"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030424" secondary="axon" version="SP_191"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MHTGGETSACKPSSVRLAPSFSFHAAGLQMAAQMPHSHQYSDRRQPSISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWSLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFSANTGPAHYMTEGHLAMRQGADREESPMTGVCVQQSPVASS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="16608">
                <names>
                    <shortLabel>dyrk1a-dyrk1a-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-80352" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>16606</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="16609">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-80353" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>16607</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="16610">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-80354" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>16607</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
