<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2013-09-02+01:00">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0471" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="17135203" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-80017" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579228" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it/mint</attribute>
                <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
                <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">MINT-[0-9]+</attribute>
                <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
                <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="7875">
                <names>
                    <shortLabel>falck-2001-1</shortLabel>
                    <fullName>The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="11298456" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-576223" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="doi" dbAc="MI:0574" id="10.1038/35071124" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7820679" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="11298456" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="MINT-5213933" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-4">
                        <names>
                            <shortLabel>in vivo</shortLabel>
                            <fullName>in vivo</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0019" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-98" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Falck J., Mailand N., Syljuåsen RG., Bartek J., Lukas J.</attribute>
                    <attribute name="journal" nameAc="MI:0885">Nature (0028-0836)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2001</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="7876">
                <names>
                    <shortLabel>mpip1_human</shortLabel>
                    <fullName>M-phase inducer phosphatase 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Dual specificity phosphatase Cdc25A</alias>
                    <alias typeAc="MI:0301" type="gene name">CDC25A</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P30304" version="SP_73" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008283" secondary="cell population proliferation" version="SP_202"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-166N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010971" secondary="positive regulation of G2/M transition of mitotic cell cycle" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0110032" secondary="positive regulation of G2/MI transition of meiotic cell cycle" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1362277" version="SP_202"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000164045" version="SP_202" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69273" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000079" secondary="regulation of cyclin-dependent protein serine/threonine kinase activity" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034644" secondary="cellular response to UV" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69601" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5689880" version="SP_202"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8IZH5" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9H2F2" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-747671" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_963861.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1C25" version="SP_202"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001763" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_202"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000302506" version="SP_202" refType="transcript"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8862803" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-156711" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004725" secondary="protein tyrosine phosphatase activity" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69656" version="SP_202"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P30304" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000086" secondary="G2/M transition of mitotic cell cycle" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000082" secondary="G1/S transition of mitotic cell cycle" version="SP_202"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000751" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69202" version="SP_202"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000303706" version="SP_202" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q96IL3" version="SP_73" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036873" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" secondary="cell division" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_202"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-176187" version="SP_202"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011532618.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004721" secondary="phosphoprotein phosphatase activity" version="SP_202"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001780.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009314" secondary="response to radiation" version="SP_202"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051087" secondary="chaperone binding" version="SP_202"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MELGPEPPHRRRLLFACSPPPASQPVVKALFGASAAGGLSPVTNLTVTMDQLQGLGSDYEQPLEVKNNSNLQRMGSSESTDSGFCLDSPGPLDSKENLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLHSHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGENLKNEEETPSCMASLWTAPLVMRTTNLDNRCKLFDSPSLCSSSTRSVLKRPERSQEESPPGSTKRRKSMSGASPKESTNPEKAHETLHQSLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLLKKPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLKKFRTKSRTWAGEKSKREMYSRLKKL</sequence>
            </interactor>
            <interactor id="7877">
                <names>
                    <shortLabel>chk2_human</shortLabel>
                    <fullName>Serine/threonine-protein kinase Chk2</fullName>
                    <alias typeAc="MI:0301" type="gene name">CHEK2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CHK2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">RAD53</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cds1 homolog</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Checkpoint kinase 2</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CDS1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CHK2 checkpoint homolog</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="O96017" version="SP_94" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" secondary="regulation of transcription, DNA-templated" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA12" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000086" secondary="G2/M transition of mitotic cell cycle" version="SP_236"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="O96017" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDE" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA04" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5693565" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UGF1" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000385747" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016605" secondary="PML body" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035690" secondary="cellular response to drug" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050821" secondary="protein stabilization" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA10" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YCR" version="SP_236"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-24270N"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000386087" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YIQ" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA06" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006975" secondary="DNA damage induced protein phosphorylation" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDC" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006978" secondary="DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042770" secondary="signal transduction in response to DNA damage" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903416" secondary="response to glycoside" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WTC" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69601" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HBS5" version="SP_156" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011528147.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000497000" version="SP_236" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008630" secondary="intrinsic apoptotic signaling pathway in response to DNA damage" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046777" secondary="protein autophosphorylation" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6804756" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_665861.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0018105" secondary="peptidyl-serine phosphorylation" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3I6W" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044773" secondary="mitotic DNA damage checkpoint signaling" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000650281" version="SP_236" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005794" secondary="Golgi apparatus" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001005735.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDJ" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA08" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001934" secondary="positive regulation of protein phosphorylation" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7ZBF3" version="SP_121" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDA" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2CN8" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDH" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3I6U" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2XK9" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000077" secondary="DNA damage checkpoint signaling" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001244316.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A9R" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071480" secondary="cellular response to gamma radiation" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006977" secondary="DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042771" secondary="intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000210" secondary="positive regulation of anoikis" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7ZBF5" version="SP_121" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A9T" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDF" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9HCQ8" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903926" secondary="cellular response to bisphenol A" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2XM8" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA03" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042176" secondary="regulation of protein catabolic process" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016884050.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69541" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008984" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044257" secondary="cellular protein catabolic process" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901796" secondary="regulation of signal transduction by p53 class mediator" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YCS" version="SP_236"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_009125.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YIR" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA05" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA13" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000002" secondary="negative regulation of DNA damage checkpoint" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDD" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W0J" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006974" secondary="cellular response to DNA damage stimulus" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K3Y9" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75035" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WTD" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YCQ" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6804757" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WTJ" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA07" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6QA11" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090399" secondary="replicative senescence" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDK" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6804760" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004674" secondary="protein serine/threonine kinase activity" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000405598" version="SP_236" refType="transcript"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9UGF0" version="SP_94" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDB" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000404276" version="SP_236" refType="transcript"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VA4" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A9U" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDI" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2XBJ" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" secondary="cell division" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090307" secondary="mitotic spindle assembly" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YCF" version="SP_236"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1180783" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2CN5" version="SP_236"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69473" version="SP_236"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B7ZBF4" version="SP_121" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1GXC" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2WTI" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BDG" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2XM9" version="SP_236"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000253" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006302" secondary="double-strand break repair" version="SP_236"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000183765" version="SP_236" refType="gene"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2YIT" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_236"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031573" secondary="mitotic intra-S DNA damage checkpoint signaling" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4A9S" version="SP_236"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W7X" version="SP_236"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MSRESDVEAQQSHGSSACSQPHGSVTQSQGSSSQSQGISSSSTSTMPNSSQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTALPQVLAQPSTSRKRPREGEAEGAETTKRPAVCAAVL</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="7878">
                <names>
                    <shortLabel>chek2-cdc25a-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-15591" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7820687" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>7875</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="7879">
                        <names>
                            <shortLabel>mpip1_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-576228" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7820694" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>7876</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="7880">
                        <names>
                            <shortLabel>chk2_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-576225" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7820691" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>7877</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>phosphorylation</shortLabel>
                        <fullName>phosphorylation reaction</fullName>
                        <alias typeAc="MI:1041" type="synonym">phosphorylation</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0217" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0039" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0033" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0034" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="go" dbAc="MI:0448" id="GO:0016310" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49922" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0035" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0222" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0037" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0036" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="resid" dbAc="MI:0248" id="AA0038" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
