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    <entry>
        <source releaseDate="2004-02-01Z">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
            </names>
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            <attributeList>
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                <attribute name="url" nameAc="MI:0614">url&amp;gt;http://mint.bio.uniroma2.it/mint/</attribute>
                <attribute name="url" nameAc="MI:0614">https://mint.bio.uniroma2.it</attribute>
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                <attribute name="search-url" nameAc="MI:0615">https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac}</attribute>
                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
                <attribute name="url" nameAc="MI:0614">http://mint.bio.uniroma2.it</attribute>
                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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        </source>
        <experimentList>
            <experimentDescription id="5251">
                <names>
                    <shortLabel>pyronnet-1999-1</shortLabel>
                    <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.</fullName>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human</shortLabel>
                            <fullName>Homo sapiens</fullName>
                            <alias typeAc="MI:1041" type="synonym">Human</alias>
                        </names>
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                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">coip</alias>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>polyclonal western</shortLabel>
                        <fullName>polyclonal antibody western blot</fullName>
                        <alias typeAc="MI:1041" type="synonym">polyclonal western</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Pyronnet S., Imataka H., Gingras AC., Fukunaga R., Hunter T., Sonenberg N.</attribute>
                    <attribute name="journal" nameAc="MI:0885">EMBO J. (0261-4189)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">1999</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="5252">
                <names>
                    <shortLabel>mknk1_human</shortLabel>
                    <fullName>MAP kinase-interacting serine/threonine-protein kinase 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">MAP kinase signal-integrating kinase 1</alias>
                    <alias typeAc="MI:0301" type="gene name">MKNK1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MNK1</alias>
                </names>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL</sequence>
            </interactor>
            <interactor id="5253">
                <names>
                    <shortLabel>if4e_human</shortLabel>
                    <fullName>Eukaryotic translation initiation factor 4E</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">mRNA cap-binding protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">eIF-4F 25 kDa subunit</alias>
                    <alias typeAc="MI:0301" type="gene name">EIF4E</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EIF4EL1</alias>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV</sequence>
            </interactor>
            <interactor id="5254">
                <names>
                    <shortLabel>if4g1_human</shortLabel>
                    <fullName>Eukaryotic translation initiation factor 4 gamma 1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">p220</alias>
                    <alias typeAc="MI:0301" type="gene name">EIF4G1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EIF4G</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EIF4GI</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">EIF4F</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q04637" version="SP_82" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000350481"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_231"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q04637" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060964" secondary="regulation of gene silencing by miRNA" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T46" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900087" secondary="positive regulation of G1/S transition of mitotic cell cycle" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905537" secondary="positive regulation of eukaryotic translation initiation factor 4F complex assembly" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O43177" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006412" secondary="translation" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-156827" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000434061"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000376320"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O95066" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5HYG0" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905606" secondary="regulation of presynapse assembly" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008135" secondary="translation factor activity, RNA binding" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6ZN21" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000352767"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72662" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003743" secondary="translation initiation factor activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010494" secondary="cytoplasmic stress granule" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-166208" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W97" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000343450"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4AZA" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000371767"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="E9PFM1" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016021" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000411826"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005844" secondary="polysome" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003891" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" secondary="negative regulation of neuron death" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000317600"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72702" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_937884.1"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EHC" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72649" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003890" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-450408" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000391935"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9010553" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033138" secondary="positive regulation of peptidyl-serine phosphorylation" version="SP_231"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-1161N"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8N102" version="SP_82" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905696" secondary="regulation of polysome binding" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975957" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010801" secondary="negative regulation of peptidyl-threonine phosphorylation" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000316879"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000392537"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000338020"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_937885.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002191" secondary="cap-dependent translational initiation" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT4" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1UG3" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032502" secondary="developmental process" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097009" secondary="energy homeostasis" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LJ2" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003723" secondary="RNA binding" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EI3" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003307" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4F02" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0080135" secondary="regulation of cellular response to stress" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032270" secondary="positive regulation of cellular protein metabolic process" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010942" secondary="positive regulation of cell death" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905612" secondary="positive regulation of mRNA cap binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_231"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-73711" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT2" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-11020102" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031669" secondary="cellular response to nutrient levels" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006446" secondary="regulation of translational initiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006413" secondary="translational initiation" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-72706" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000424196"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031369" secondary="translation initiation factor binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036493" secondary="positive regulation of translation in response to endoplasmic reticulum stress" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010507" secondary="negative regulation of autophagy" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-975956" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000114867" version="SP_231" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" secondary="membrane" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6ZMW" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004944.3"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000316879" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="G5E9S1" version="SP_151" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008190" secondary="eukaryotic initiation factor 4E binding" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000346169" version="SP_231" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905618" secondary="positive regulation of miRNA mediated inhibition of translation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003729" secondary="mRNA binding" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000414031"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="D3DNT5" version="SP_126" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-429947" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030307" secondary="positive regulation of cell growth" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" secondary="eukaryotic translation initiation factor 4F complex" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016024" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000382330"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_886553.3"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EIR" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034645" secondary="cellular macromolecule biosynthetic process" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060090" secondary="molecular adaptor activity" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037584" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1169408" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001662" secondary="behavioral fear response" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000416255"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000342981"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28974642" refType="intact-secondary"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045666" secondary="positive regulation of neuron differentiation" version="SP_231"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-13580-1" id="5255">
                <names>
                    <shortLabel>eif4e-mnk1</shortLabel>
                    <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-73920" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
                </xref>
                <experimentList>
                    <experimentRef>5251</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="5256">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-73921" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5252</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="5257">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-73922" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5253</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">The interaction between eif4e and mnk1 is indirect. mnk1 interacts directly with eif4e interacting protein eif4g, rather than with eif4e.</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-13580-2" id="5258">
                <names>
                    <shortLabel>mnk1-eif4e</shortLabel>
                    <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-73979" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-2" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>5251</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="5259">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-73980" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5253</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="5260">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-73981" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5252</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">The interaction between mnk1 and eif4e is indirect. mnk1 interacts directly with eif4e interacting protein eif4g, rather than with eif4e.</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-13580-3" id="5261">
                <names>
                    <shortLabel>eif4g-mnk1</shortLabel>
                    <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-73986" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-3" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>5251</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="5262">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-73987" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5254</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="5263">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-74020" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5252</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
            <interaction imexId="IM-13580-4" id="5264">
                <names>
                    <shortLabel>mnk1-eif4g</shortLabel>
                    <fullName>Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-74022" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016281" refType="component" refTypeAc="MI:0354"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-13580-4" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>5251</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="5265">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-74024" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5252</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="5266">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-74023" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>5254</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
