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    <entry>
        <source releaseDate="2013-09-02+01:00">
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                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
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            <attributeList>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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        <experimentList>
            <experimentDescription id="6015">
                <names>
                    <shortLabel>pathan-2001-1</shortLabel>
                    <fullName>TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer.</fullName>
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                        <names>
                            <shortLabel>in vivo</shortLabel>
                            <fullName>in vivo</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
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                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                    <xref>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Pathan N., Marusawa H., Krajewska M., Matsuzawa S., Kim H., Okada K., Torii S., Kitada S., Krajewski S., Welsh K., Pio F., Godzik A., Reed JC.</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2001</attribute>
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            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="6016">
                <names>
                    <shortLabel>card8_human</shortLabel>
                    <fullName>Caspase recruitment domain-containing protein 8</fullName>
                    <alias typeAc="MI:0301" type="gene name">CARD8</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">KIAA0955</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">NDPP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CARD-inhibitor of NF-kappa-B-activating ligand</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">DACAR</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Tumor up-regulated CARD-containing antagonist of CASP9</alias>
                </names>
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                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
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                </organism>
                <sequence>MEKKECPEKSSSSEEELPRRDSGSSRNIDASKLIRLQGSRKLLVDNSIRELQYTKTGIFFQAEACVTNDTVYRELPCVSETLCDISHFFQEDDETEAEPLLFRAVPECQLSGGDIPSVSEEQESSEGQDSGDICSEENQIVSSYASKVCFEIEEDYKNRQFLGPEGNVDVELIDKSTNRYSVWFPTAGWYLWSATGLGFLVRDEVTVTIAFGSWSQHLALDLQHHEQWLVGGPLFDVTAEPEEAVAEIHLPHFISLQAGEVDVSWFLVAHFKNEGMVLEHPARVEPFYAVLESPSFSLMGILLRIASGTRLSIPITSNTLIYYHPHPEDIKFHLYLVPSDALLTKAIDDEEDRFHGVRLQTSPPMEPLNFGSSYIVSNSANLKVMPKELKLSYRSPGEIQHFSKFYAGQMKEPIQLEITEKRHGTLVWDTEVKPVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEKTRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQQNL</sequence>
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                    <shortLabel>casp9_human</shortLabel>
                    <fullName>Caspase-9</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">Apoptotic protease Mch-6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Apoptotic protease-activating factor 3</alias>
                    <alias typeAc="MI:0301" type="gene name">CASP9</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MCH6</alias>
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                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O95348" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001309" version="SP_229"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011029" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3D9T" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5JUY" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043525" secondary="positive regulation of neuron apoptotic process" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5WVE" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198323" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-418889" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-168638" version="SP_229"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P55211" version="SP_229"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005246071.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097200" secondary="cysteine-type endopeptidase activity involved in execution phase of apoptosis" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111458" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071549" secondary="cellular response to dexamethasone stimulus" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005739" secondary="mitochondrion" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034644" secondary="cellular response to UV" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008630" secondary="intrinsic apoptotic signaling pathway in response to DNA damage" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4RHW" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006919" secondary="activation of cysteine-type endopeptidase activity involved in apoptotic process" version="SP_229"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001220.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008233" secondary="peptidase activity" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3V3K" version="SP_229"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001315" version="SP_229"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q53Y70" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032025" secondary="response to cobalt ion" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111463" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1NW9" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JXQ" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_229"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_127463.2"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5WVC" version="SP_229"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000333868" version="SP_229" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029030" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0034349" secondary="glial cell apoptotic process" version="SP_229"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5UGI1" version="SP_141" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2AR9" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097199" secondary="cysteine-type endopeptidase activity involved in apoptotic signaling pathway" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111464" version="SP_229"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q5JRU9" version="SP_119" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001822" secondary="kidney development" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9627069" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111459" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007568" secondary="aging" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046677" secondary="response to antibiotic" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004197" secondary="cysteine-type endopeptidase activity" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_229"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="6018">
                <names>
                    <shortLabel>card8-casp9</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-17223" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7871109" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>6015</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="6019">
                        <names>
                            <shortLabel>card8_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-579770" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7871116" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>6016</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="6020">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-579771" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001315" secondary="CARD" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7871119" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="451"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="537"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="6021">
                        <names>
                            <shortLabel>casp9_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-579776" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7871113" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>6017</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
