MINT MINT, Dpt of Biology, University of Rome Tor Vergata MINT http://mint.bio.uniroma2.it/mint url>http://mint.bio.uniroma2.it/mint/ https://mint.bio.uniroma2.it MINT-[0-9]+ https://mint.bio.uniroma2.it/index.php/results-interactions/?id=${ac} The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules. http://mint.bio.uniroma2.it http://mint.bio.uniroma2.it/mint ferby-1999-1 A novel p34(cdc2)-binding and activating protein that is necessary and sufficient to trigger G(2)/M progression in Xenopus oocytes. in vitro In vitro pull down pull down predetermined predetermined participant predetermined Ferby I., Blazquez M., Palmer A., Eritja R., Nebreda AR. Genes Dev. (0890-9369) 1999 spd1a_xenla Speedy protein 1-A spdya-a Protein Ls26 Rapid inducer of G2/M progression in oocytes A XSpy1-A ls26 p33 ringo-A spdy1 protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MRHMQSVTRATSICGSGVKQVIGKGHPHARVVGARKARIPEREELSVKPKMVRNTHLNLQPQERQAFYRLLENEQIQEFLSMDSCLRISDKYLIAMVLAYFKRAGLYTSEYTTMNFFVALYLANDMEEDEEDYKYEIFPWALGDSWRELFPQFLRLRDDFWAKMNYRAVVSRRCCDEVMSKDPTHWAWLRDRPIHHSGAMRGYLRNEDDFSPRGPGLTPASCTLCHKAGVCDSGGVSHNNSSSPEQEIFHYTNREWSQELLMLSPELLLDPECTHDLHILQEPLVGLEPDGTALEWHHL mint Stimulates oocyte maturation by promoting meiotic G2/M progression in resting oocytes, via activation of the MAPK cascade and cdc2-cyclin B. Also activates the kinase activity of cdk2; this activation does not appear necessary for oocyte maturation. Necessary for polyadenylation in oocytes cdk1a_xenla Cyclin-dependent kinase 1-A cdc2x1.1 p34 protein kinase 1 Cell division control protein 2 homolog 1 cdk1-a cdc2-a Cell division control protein 2-A Cell division protein kinase 1-A protein protein xenla Xenopus laevis (African clawed frog) African clawed frog MDEYTKIEKIGEGTYGVVYKGRHKATGQVVAMKKIRLENEEEGVPSTAIREISLLKELQHPNIVCLLDVLMQDSRLYLIFEFLSMDLKKYLDSIPSGQYIDTMLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDSKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRAPEVLLGSVRYSTPVDVWSIGTIFAEIATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNSFPKWKGGSLSANVKNIDKDGLDLLAKMLIYDPAKRISARKALLHPYFDDLDKSSLPDNQIRN mint Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. Component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II spdya_a-cdk1_a 4016 spd1a_xenla 4017 unspecified role unspecified role bait bait purified purified Stoichiometry: 1.0 cdk1a_xenla 4018 unspecified role unspecified role prey prey purified purified Stoichiometry: 1.0 direct interaction direct interaction false false false Ringo binds and activates p34-CDC2. but it does not associate with p34-Cdc2/cyclin B complex mint