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    <entry>
        <source releaseDate="2013-09-02+01:00">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
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            <attributeList>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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        <experimentList>
            <experimentDescription id="759717">
                <names>
                    <shortLabel>guerra-2008-1</shortLabel>
                    <fullName>Vaccinia virus E3 protein prevents the antiviral action of ISG15.</fullName>
                </names>
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                    <hostOrganism ncbiTaxId="-3">
                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
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                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Guerra S., Cáceres A., Knobeloch KP., Horak I., Esteban M.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">sguerra@cnb.csic.es</attribute>
                    <attribute name="journal" nameAc="MI:0885">PLoS Pathog. (1553-7366)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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            <experimentDescription id="759718">
                <names>
                    <shortLabel>guerra-2008-2</shortLabel>
                    <fullName>Vaccinia virus E3 protein prevents the antiviral action of ISG15.</fullName>
                </names>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-3">
                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>fluorescence imaging</shortLabel>
                        <fullName>fluorescence microscopy</fullName>
                        <alias typeAc="MI:1041" type="synonym">fluorescence imaging</alias>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Guerra S., Cáceres A., Knobeloch KP., Horak I., Esteban M.</attribute>
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                    <attribute name="contact-email" nameAc="MI:0634">sguerra@cnb.csic.es</attribute>
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                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="759719">
                <names>
                    <shortLabel>ub2l6_human</shortLabel>
                    <fullName>Ubiquitin/ISG15-conjugating enzyme E2 L6</fullName>
                    <alias typeAc="MI:0301" type="gene name">UBE2L6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">UBCH8</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ubiquitin-protein ligase L6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Ubiquitin carrier protein L6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">UbcH8</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Retinoic acid-induced gene B protein</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">E2 ubiquitin-conjugating enzyme L6</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="O14933" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006511" secondary="ubiquitin-dependent protein catabolic process" version="SP_200"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004214.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-936440" version="SP_200"/>
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                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000287156" version="SP_200" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032020" secondary="ISG15-protein conjugation" version="SP_200"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5656169" version="SP_200"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000151" secondary="ubiquitin ligase complex" version="SP_200"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000341980"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_200"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006464" secondary="cellular protein modification process" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000209" secondary="protein polyubiquitination" version="SP_200"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_200"/>
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                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000156587" version="SP_200" refType="gene"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS</sequence>
            </interactor>
            <interactor id="759720">
                <names>
                    <shortLabel>e3_vaccw</shortLabel>
                    <fullName>Protein E3</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">p25</alias>
                    <alias typeAc="MI:0306" type="orf name">E3L</alias>
                    <alias typeAc="MI:0305" type="locus name">VACWR059</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P21605" version="SP_72" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003726" secondary="double-stranded RNA adenosine deaminase activity" version="SP_112"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019050" secondary="suppression by virus of host apoptotic process" version="SP_112"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036388" version="SP_112"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0039557" secondary="suppression by virus of host IRF7 activity" version="SP_112"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014720" version="SP_112"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q76ZW2" version="SP_72" refType="secondary-ac" refTypeAc="MI:0360"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0039580" secondary="suppression by virus of host PKR activity" version="SP_112"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="YP_232941.1"/>
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                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-2175N"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0039501" secondary="suppression by virus of host type I interferon production" version="SP_112"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR009179" version="SP_112"/>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                    <xref>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10254">
                    <names>
                        <shortLabel>vaccw</shortLabel>
                        <fullName>vaccinia virus (stra</fullName>
                        <alias typeAc="MI:1041" type="synonym">Vaccinia virus (strain WR)</alias>
                        <alias typeAc="MI:1041" type="synonym">VACV</alias>
                    </names>
                </organism>
                <sequence>MSKIYIDERSNAEIVCEAIKTIGIEGATAAQLTRQLNMEKREVNKALYDLQRSAMVYSSDDIPPRWFMTTEADKPDADAMADVIIDDVSREKSMREDHKSFDDVIPAKKIIDWKGANPVTVINEYCQITRRDWSFRIESVGPSNSPTFYACVDIDGRVFDKADGKSKRDAKNNAAKLAVDKLLGYVIIRF</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="759721">
                <names>
                    <shortLabel>e3-ube2l6</shortLabel>
                </names>
                <xref>
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                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009816" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>759717</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="759722">
                        <names>
                            <shortLabel>ub2l6_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741177" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14933" secondary="O14933"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009826" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>759719</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="759723">
                        <names>
                            <shortLabel>ve03_vaccw</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741179" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009823" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P21605" secondary="P21605"/>
                        </xref>
                        <interactorRef>759720</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="759724">
                <names>
                    <shortLabel>e3-ube2l6-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741183" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009859" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>759718</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="759725">
                        <names>
                            <shortLabel>ub2l6_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741186" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009869" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14933" secondary="O14933"/>
                        </xref>
                        <interactorRef>759719</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="759726">
                        <names>
                            <shortLabel>ve03_vaccw</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6741184" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P21605" secondary="P21605"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-8009866" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>759720</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
