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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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            <experimentDescription id="544227">
                <names>
                    <shortLabel>lee-2006i-1</shortLabel>
                    <fullName>Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells.</fullName>
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                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-vsmc</shortLabel>
                            <fullName>Homo sapiens aortic vascular smooth muscle cells</fullName>
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                                <fullName>Human aortic vascular smooth muscle cells</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>anti bait coip</shortLabel>
                        <fullName>anti bait coimmunoprecipitation</fullName>
                        <alias typeAc="MI:1041" type="synonym">anti bait coip</alias>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
                        <alias typeAc="MI:1041" type="synonym">predetermined</alias>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Lee B., Kim CH., Moon SK.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">FEBS Lett. (0014-5793)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2006</attribute>
                    <attribute name="imex-exported">2009-01-08</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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            </experimentDescription>
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                <names>
                    <shortLabel>cdn1a_human</shortLabel>
                    <fullName>Cyclin-dependent kinase inhibitor 1</fullName>
                    <alias typeAc="MI:0301" type="gene name">CDKN1A</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CAP20</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CDKN1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CIP1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">MDA6</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PIC1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">SDI1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">WAF1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">p21</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">CDK-interacting protein 1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Melanoma differentiation-associated protein 6</alias>
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                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
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                <sequence>MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP</sequence>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097135" secondary="cyclin E2-CDK2 complex" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OIR" version="SP_255"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3R7I" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2EXM" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BGH" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1W8C" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2X1N" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6Q4G" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1V1K" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HCK" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4BCN" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3R83" version="SP_255"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046872" secondary="metal ion binding" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3BHT" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4EZ7" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1VYW" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6GVA" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W06" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4CFU" version="SP_255"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K7C6" version="SP_132" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-161N"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4FKL" version="SP_255"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060968" secondary="regulation of gene silencing" version="SP_255"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6GUE" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4FKU" version="SP_255"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2R3M" version="SP_255"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL</sequence>
            </interactor>
            <interactor id="544230">
                <names>
                    <shortLabel>cdk4_human</shortLabel>
                    <fullName>Cyclin-dependent kinase 4</fullName>
                    <alias typeAc="MI:0301" type="gene name">CDK4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">Cell division protein kinase 4</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">PSK-J3</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P11802" version="SP_106" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071222" secondary="cellular response to lipopolysaccharide" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009636" secondary="response to toxic substance" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8849470" version="SP_245"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000257904" version="SP_245" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071353" secondary="cellular response to interleukin-4" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FWL" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045727" secondary="positive regulation of translation" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048471" secondary="perinuclear region of cytoplasm" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W9Z" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060612" secondary="adipose tissue development" version="SP_245"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q6FG61" version="SP_129" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P8G" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097129" secondary="cyclin D2-CDK4 complex" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000082" secondary="G1/S transition of mitotic cell cycle" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043065" secondary="positive regulation of apoptotic process" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106310" secondary="protein serine kinase activity" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1LD2" version="SP_245"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000135446" version="SP_245" refType="gene"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9630791" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016538" secondary="cyclin-dependent protein serine/threonine kinase regulator activity" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9632700" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-912446" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W9F" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FWP" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004693" secondary="cyclin-dependent protein serine/threonine kinase activity" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W96" version="SP_245"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P11802" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P8E" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000307" secondary="cyclin-dependent protein kinase holoenzyme complex" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559582" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3G33" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0055093" secondary="response to hyperoxia" version="SP_245"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000257904" version="SP_245" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904628" secondary="cellular response to phorbol 13-acetate 12-myristate" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-187577" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048146" secondary="positive regulation of fibroblast proliferation" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007623" secondary="circadian rhythm" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_245"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-295644" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060260" secondary="regulation of transcription initiation from RNA polymerase II promoter" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2W99" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045793" secondary="positive regulation of cell size" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904637" secondary="cellular response to ionomycin" version="SP_245"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017441" version="SP_245"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000066.1"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011009" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006468" secondary="protein phosphorylation" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-381340" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P8H" version="SP_245"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008271" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050994" secondary="regulation of lipid catabolic process" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8878166" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559580" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" secondary="signal transduction" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-75815" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FWM" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032869" secondary="cellular response to insulin stimulus" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005667" secondary="transcription regulator complex" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010971" secondary="positive regulation of G2/M transition of mitotic cell cycle" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6P8F" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005524" secondary="ATP binding" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033574" secondary="response to testosterone" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046890" secondary="regulation of lipid biosynthetic process" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9616222" version="SP_245"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-875N"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046626" secondary="regulation of insulin receptor signaling pathway" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031965" secondary="nuclear membrane" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" secondary="cell division" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" secondary="chromatin" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008284" secondary="positive regulation of cell population proliferation" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016592" secondary="mediator complex" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9661069" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559585" version="SP_245"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O00576" version="SP_106" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-69231" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040014" secondary="regulation of multicellular organism growth" version="SP_245"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000719" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010288" secondary="response to lead ion" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0002088" secondary="lens development in camera-type eye" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010468" secondary="regulation of gene expression" version="SP_245"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B2R9A0" version="SP_178" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B4DNF9" version="SP_180" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0106311" secondary="protein threonine kinase activity" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030332" secondary="cyclin binding" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008353" secondary="RNA polymerase II CTD heptapeptide repeat kinase activity" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005923" secondary="bicellular tight junction" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-3214858" version="SP_245"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5FWK" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031100" secondary="animal organ regeneration" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9632697" version="SP_245"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9630794" version="SP_245"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_245"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-11090-1" id="544231">
                <names>
                    <shortLabel>cdk2-cdkn1a-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370697" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-11090-1" refType="imex-primary" refTypeAc="MI:0662"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961591" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>544227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="544232">
                        <names>
                            <shortLabel>cdn1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370699" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961602" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>544228</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>polyclonal western</shortLabel>
                                    <fullName>polyclonal antibody western blot</fullName>
                                    <alias typeAc="MI:1041" type="synonym">polyclonal western</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-964" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="544233">
                        <names>
                            <shortLabel>cdk2_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370698" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961599" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>544229</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>polyclonal western</shortLabel>
                                    <fullName>polyclonal antibody western blot</fullName>
                                    <alias typeAc="MI:1041" type="synonym">polyclonal western</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-964" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4B</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction imexId="IM-11090-2" id="544234">
                <names>
                    <shortLabel>cdk4-cdkn1a-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370718" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961650" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-11090-2" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>544227</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="544235">
                        <names>
                            <shortLabel>cdn1a_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370725" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961661" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>544228</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>polyclonal western</shortLabel>
                                    <fullName>polyclonal antibody western blot</fullName>
                                    <alias typeAc="MI:1041" type="synonym">polyclonal western</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-964" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="544236">
                        <names>
                            <shortLabel>cdk4_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-3370719" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6961658" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>544230</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>polyclonal western</shortLabel>
                                    <fullName>polyclonal antibody western blot</fullName>
                                    <alias typeAc="MI:1041" type="synonym">polyclonal western</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0086" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-964" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>living cell</shortLabel>
                                    <fullName>living cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0349" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537765" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4B</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
