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                    <fullName>Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.</fullName>
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                    <attribute name="author-list" nameAc="MI:0636">Bache KG., Brech A., Mehlum A., Stenmark H.</attribute>
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                    <attribute name="journal" nameAc="MI:0885">J. Cell Biol. (0021-9525)</attribute>
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                    <fullName>Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.</fullName>
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                    <attribute name="publication year" nameAc="MI:0886">2003</attribute>
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                    <shortLabel>bache-2003-3</shortLabel>
                    <fullName>Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.</fullName>
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                        <names>
                            <shortLabel>human-hela</shortLabel>
                            <fullName>Homo sapiens epitheloid cervix carcinoma cells</fullName>
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                                <shortLabel>hela</shortLabel>
                                <fullName>Human epitheloid cervix carcinoma HeLa cells</fullName>
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                            <attributeList>
                                <attribute name="comment" nameAc="MI:0612">derivation: cervix; epithelial; adenocarcinoma</attribute>
                                <attribute name="comment" nameAc="MI:0612">ATCC no:CCL-2</attribute>
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                    <fullName>Hepatocyte growth factor-regulated tyrosine kinase substrate</fullName>
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                <interactorType>
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                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
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                <sequence>MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESVVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNKKAEGKASSTTELPPEYLTSPLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKTTYTAHPKAEPTPLASSAPPAGSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETDSQPITPCSGPFSEYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPTAGGVLYQPSGPTSFPATFSPAGSVEGSPMHGVYMSQPAPATGPYPSMPGTTADPSMVSAYMYPTGAPGAQAAPQAQAGPTTSPAYSSYQPTPTPGYQSVASQAPQSLPAISQPPQTSNIGYMGSQPMSMGYQPYNMQNLMTALPGQDASLPAQQPYIPGQQPLYQQMAPSTGPPQQQPPVAQPAPTQGPPAQGSEAQLISFD</sequence>
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                    <shortLabel>ts101_human</shortLabel>
                    <fullName>Tumor susceptibility gene 101 protein</fullName>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-162588" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005770" secondary="late endosome" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KPP" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090543" secondary="Flemming body" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015031" secondary="protein transport" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1KPQ" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000813" secondary="ESCRT I complex" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4ZNY" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008333" secondary="endosome to lysosome transport" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S1Q" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030374" secondary="nuclear receptor coactivator activity" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042059" secondary="negative regulation of epidermal growth factor receptor signaling pathway" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006513" secondary="protein monoubiquitination" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OBQ" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005771" secondary="multivesicular body" version="SP_229"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="Q99816" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030216" secondary="keratinocyte differentiation" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043130" secondary="ubiquitin binding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097352" secondary="autophagosome maturation" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003714" secondary="transcription corepressor activity" version="SP_229"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000251968"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005769" secondary="early endosome" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044877" secondary="protein-containing complex binding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903543" secondary="positive regulation of exosomal secretion" version="SP_229"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017916" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4YC1" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3IV1" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3P9H" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1M4P" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OBU" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046790" secondary="virion binding" version="SP_229"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008883" version="SP_229"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-346882" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR037202" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903551" secondary="regulation of extracellular exosome assembly" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3P9G" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4EJE" version="SP_229"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000251968" version="SP_229" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OBS" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043162" secondary="ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902188" secondary="positive regulation of viral release from host cell" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1M4Q" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9610379" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" secondary="DNA binding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070062" secondary="extracellular exosome" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990182" secondary="exosomal secretion" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-917729" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VKG" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005768" secondary="endosome" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048306" secondary="calcium-dependent protein binding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001558" secondary="regulation of cell growth" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031902" secondary="late endosome membrane" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046755" secondary="viral budding" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0039702" secondary="viral budding via host ESCRT complex" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016236" secondary="macroautophagy" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005815" secondary="microtubule organizing center" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006858" secondary="extracellular transport" version="SP_229"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000074319" version="SP_229" refType="gene"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR016135" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6VME" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007175" secondary="negative regulation of epidermal growth factor-activated receptor activity" version="SP_229"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-31809N"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-174490" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2F0R" version="SP_229"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BUM5" version="SP_85" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0036258" secondary="multivesicular body assembly" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043405" secondary="regulation of MAP kinase activity" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903774" secondary="positive regulation of viral budding via host ESCRT complex" version="SP_229"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9615710" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000397" secondary="positive regulation of ubiquitin-dependent endocytosis" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007049" secondary="cell cycle" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010008" secondary="endosome membrane" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3OBX" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031901" secondary="early endosome membrane" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051301" secondary="cell division" version="SP_229"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000251968" version="SP_229" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_229"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005730" secondary="nucleolus" version="SP_229"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6UD0" version="SP_229"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="143846">
                <names>
                    <shortLabel>hgs-tsg101-3</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-50337" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986589" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>143841</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="143847">
                        <names>
                            <shortLabel>hgs_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">Q61691</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737931" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986594" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143844</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
                                    <fullName>nucleotide sequence identification</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">nucleotide sequence</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="143848">
                                <names>
                                    <shortLabel>undefined mutation</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737934" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986602" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation decreasing</shortLabel>
                                        <fullName>mutation decreasing interaction</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">hotspot</alias>
                                        <alias typeAc="MI:1041" type="synonym">hotspot</alias>
                                        <alias typeAc="MI:1041" type="synonym">mutation decreasing</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456519" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>alanine scanning</shortLabel>
                                        <fullName>alanine scanning</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0005" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456759" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="351"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="351"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                                <attributeList>
                                    <attribute name="no-mutation-export"/>
                                </attributeList>
                            </feature>
                            <feature id="143849">
                                <names>
                                    <shortLabel>tagged molecule</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737936" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986605" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>tag</shortLabel>
                                        <fullName>tag</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0507" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456738" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="143850">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737932" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986611" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="287"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="573"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="143851">
                        <names>
                            <shortLabel>ts101_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">TS101</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737941" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986598" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143845</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
                                    <fullName>nucleotide sequence identification</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">nucleotide sequence</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="143852">
                                <names>
                                    <shortLabel>tagged molecule</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737942" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986608" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>tag</shortLabel>
                                        <fullName>tag</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0507" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456738" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="143853">
                <names>
                    <shortLabel>hgs-tsg101-4</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-50338" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986686" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>143842</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="143854">
                        <names>
                            <shortLabel>hgs_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">Q61691</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737967" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986695" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143844</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
                                    <fullName>nucleotide sequence identification</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">nucleotide sequence</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <featureList>
                            <feature id="143855">
                                <names>
                                    <shortLabel>tagged molecule</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737972" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986699" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>tag</shortLabel>
                                        <fullName>tag</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0507" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456738" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="143856">
                                <names>
                                    <shortLabel>binding site</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737968" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986702" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>deletion analysis</shortLabel>
                                        <fullName>deletion analysis</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0033" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456769" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="287"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="573"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                            <feature id="143857">
                                <names>
                                    <shortLabel>undefined mutation</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-737970" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986705" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>mutation decreasing</shortLabel>
                                        <fullName>mutation decreasing interaction</fullName>
                                        <alias typeAc="MI:0303" type="go synonym">hotspot</alias>
                                        <alias typeAc="MI:1041" type="synonym">hotspot</alias>
                                        <alias typeAc="MI:1041" type="synonym">mutation decreasing</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0119" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456519" refType="identity" refTypeAc="MI:0356"/>
                                    </xref>
                                </featureType>
                                <featureDetectionMethod>
                                    <names>
                                        <shortLabel>alanine scanning</shortLabel>
                                        <fullName>alanine scanning</fullName>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0005" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456759" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureDetectionMethod>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </startStatus>
                                        <begin position="351"/>
                                        <endStatus>
                                            <names>
                                                <shortLabel>certain</shortLabel>
                                                <fullName>certain sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">certain</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                            </xref>
                                        </endStatus>
                                        <end position="351"/>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                                <attributeList>
                                    <attribute name="no-mutation-export"/>
                                </attributeList>
                            </feature>
                        </featureList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="143858">
                        <names>
                            <shortLabel>ts101_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">TS101</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737977" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986691" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143845</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>nucleotide sequence</shortLabel>
                                    <fullName>nucleotide sequence identification</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">sequence cloning</alias>
                                    <alias typeAc="MI:1041" type="synonym">nucleotide sequence</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0078" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-958" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>over-expressed</shortLabel>
                                    <fullName>over expressed level</fullName>
                                    <alias typeAc="MI:1041" type="synonym">over-expressed</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0506" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537736" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="143859">
                <names>
                    <shortLabel>hgs-tsg101-5</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-50339" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986833" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005769" secondary="early endosome" refType="go-definition-ref" refTypeAc="MI:0242"/>
                </xref>
                <experimentList>
                    <experimentRef>143843</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="143860">
                        <names>
                            <shortLabel>hgs_mouse</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">Hrs</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737951" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986840" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143844</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                    <participant id="143861">
                        <names>
                            <shortLabel>ts101_human</shortLabel>
                            <alias typeAc="MI:0345" type="author assigned name">TS101</alias>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-737958" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6986845" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>143845</interactorRef>
                        <participantIdentificationMethodList>
                            <participantIdentificationMethod>
                                <names>
                                    <shortLabel>immunostaining</shortLabel>
                                    <fullName>immunostaining</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0422" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </participantIdentificationMethod>
                        </participantIdentificationMethodList>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>neutral component</shortLabel>
                                    <fullName>neutral component</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <experimentalPreparationList>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>physiological level</shortLabel>
                                    <fullName>physiological level</fullName>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous level</alias>
                                    <alias typeAc="MI:0303" type="go synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous</alias>
                                    <alias typeAc="MI:1041" type="synonym">endogenous level</alias>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0222" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537793" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalPreparation>
                            <experimentalPreparation>
                                <names>
                                    <shortLabel>fixed cell</shortLabel>
                                    <fullName>fixed cell</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0348" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1537839" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                            </experimentalPreparation>
                        </experimentalPreparationList>
                        <attributeList>
                            <attribute name="comment" nameAc="MI:0612">Stoichiometry: 1.0</attribute>
                        </attributeList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>colocalization</shortLabel>
                        <fullName>colocalization</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0403" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608832" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F5</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
