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    <entry>
        <source releaseDate="2013-09-02+01:00">
            <names>
                <shortLabel>MINT</shortLabel>
                <fullName>MINT, Dpt of Biology, University of Rome Tor Vergata</fullName>
                <alias typeAc="MI:1041" type="synonym">MINT</alias>
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                <attribute name="definition">The Molecular INTeraction database (MINT) is a relational database designed to store interactions between biological molecules.</attribute>
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                <attribute name="url">http://mint.bio.uniroma2.it/mint</attribute>
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            <experimentDescription id="742587">
                <names>
                    <shortLabel>amin-2000-1</shortLabel>
                    <fullName>Identification of domains of the HPV11 E1 protein required for DNA replication in vitro.</fullName>
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                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>elisa</shortLabel>
                        <fullName>enzyme linked immunosorbent assay</fullName>
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                <participantIdentificationMethod>
                    <names>
                        <shortLabel>predetermined</shortLabel>
                        <fullName>predetermined participant</fullName>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Amin AA., Titolo S., Pelletier A., Fink D., Cordingley MG., Archambault J.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">Virology (0042-6822)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2000</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
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            <experimentDescription id="742588">
                <names>
                    <shortLabel>amin-2000-2</shortLabel>
                    <fullName>Identification of domains of the HPV11 E1 protein required for DNA replication in vitro.</fullName>
                </names>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="-3">
                        <names>
                            <shortLabel>unknown</shortLabel>
                            <fullName>Unknown</fullName>
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                <interactionDetectionMethod>
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                        <shortLabel>2 hybrid</shortLabel>
                        <fullName>two hybrid</fullName>
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                        <alias typeAc="MI:0303" type="go synonym">2h</alias>
                        <alias typeAc="MI:0303" type="go synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:0303" type="go synonym">two-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">2-hybrid</alias>
                        <alias typeAc="MI:0303" type="go synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">classical two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2H</alias>
                        <alias typeAc="MI:1041" type="synonym">two-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">2-hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Gal4 transcription regeneration</alias>
                        <alias typeAc="MI:1041" type="synonym">2h</alias>
                        <alias typeAc="MI:1041" type="synonym">yeast two hybrid</alias>
                        <alias typeAc="MI:1041" type="synonym">Y2H</alias>
                        <alias typeAc="MI:1041" type="synonym">Y-2H</alias>
                        <alias typeAc="MI:1041" type="synonym">2 hybrid</alias>
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                </interactionDetectionMethod>
                <participantIdentificationMethod>
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                        <shortLabel>predetermined</shortLabel>
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                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Amin AA., Titolo S., Pelletier A., Fink D., Cordingley MG., Archambault J.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Virus - Publications including interactions involving viral proteins</attribute>
                    <attribute name="journal" nameAc="MI:0885">Virology (0042-6822)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2000</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">rapid curation</attribute>
                    <attribute name="rapid curation" nameAc="MI:0961">rapid curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="742589">
                <names>
                    <shortLabel>ve1_hpv11</shortLabel>
                    <fullName>Replication protein E1</fullName>
                    <alias typeAc="MI:0301" type="gene name">E1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">ATP-dependent helicase E1</alias>
                </names>
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                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                </interactorType>
                <organism ncbiTaxId="10580">
                    <names>
                        <shortLabel>hpv11</shortLabel>
                        <fullName>Human papillomavirus type 11</fullName>
                    </names>
                </organism>
                <sequence>MADDSGTENEGSGCTGWFMVEAIVEHTTGTQISEDEEEEVEDSGYDMVDFIDDRHITQNSVEAQALFNRQEADAHYATVQDLKRKYLGSPYVSPISNVANAVESEISPRLDAIKLTTQPKKVKRRLFETRELTDSGYGYSEVEAATQVEKHGDPENGGDGQERDTGRDIEGEGVEHREAEAVDDSTREHADTSGILELLKCKDIRSTLHGKFKDCFGLSFVDLIRPFKSDRTTCADWVVAGFGIHHSIADAFQKLIEPLSLYAHIQWLTNAWGMVLLVLIRFKVNKSRCTVARTLGTLLNIPENHMLIEPPKIQSGVRALYWFRTGISNASTVIGEAPEWITRQTVIEHSLADSQFKLTEMVQWAYDNDICEESEIAFEYAQRGDFDSNARAFLNSNMQAKYVKDCAIMCRHYKHAEMKKMSIKQWIKYRGTKVDSVGNWKPIVQFLRHQNIEFIPFLSKLKLWLHGTPKKNCIAIVGPPDTGKSCFCMSLIKFLGGTVISYVNSCSHFWLQPLTDAKVALLDDATQPCWTYMDTYMRNLLDGNPMSIDRKHRALTLIKCPPLLVTSNIDISKEEKYKYLHSRVTTFTFPNPFPFDRNGNAVYELSDANWKCFFERLSSSLDIEDSEDEEDGSNSQAFRCVPGSVVRTL</sequence>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                    <attribute name="function" nameAc="MI:0613">ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins</attribute>
                </attributeList>
            </interactor>
            <interactor id="742590">
                <names>
                    <shortLabel>dpola_human</shortLabel>
                    <fullName>DNA polymerase alpha catalytic subunit</fullName>
                    <alias typeAc="MI:0301" type="gene name">POLA1</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">POLA</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">DNA polymerase alpha catalytic subunit p180</alias>
                </names>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000166" secondary="nucleotide binding" version="SP_208"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902975" secondary="mitotic DNA replication initiation" version="SP_208"/>
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                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
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                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="742591">
                <names>
                    <shortLabel>pola1-e1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628107" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318588" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>742587</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="742592">
                        <names>
                            <shortLabel>ve1_hpv11</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628108" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318598" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P04014" secondary="P04014"/>
                        </xref>
                        <interactorRef>742589</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="742593">
                        <names>
                            <shortLabel>dpola_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628110" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318595" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P09884" secondary="P09884"/>
                        </xref>
                        <interactorRef>742590</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>proximity</shortLabel>
                        <fullName>proximity</fullName>
                        <alias typeAc="MI:1041" type="synonym">close-contact colocalization</alias>
                        <alias typeAc="MI:1041" type="synonym">neighbourhood interaction</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
            <interaction id="742594">
                <names>
                    <shortLabel>pola1-e1-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628114" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318633" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>742588</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="742595">
                        <names>
                            <shortLabel>ve1_hpv11</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628115" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P04014" secondary="P04014"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318640" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>742589</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="742596">
                        <names>
                            <shortLabel>dpola_human</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="mint" dbAc="MI:0471" id="MINT-6628117" refType="identity" refTypeAc="MI:0356"/>
                            <secondaryRef db="uniprotkb" dbAc="MI:0486" id="P09884" secondary="P09884"/>
                            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-7318643" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>742590</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">F4</attribute>
                    <attribute name="comment" nameAc="MI:0612">homomint</attribute>
                    <attribute name="comment" nameAc="MI:0612">mint</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
