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    <entry>
        <source releaseDate="2005-01-01Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
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                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
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            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="168021">
                <names>
                    <shortLabel>lazzell-2004-1</shortLabel>
                    <fullName>SV2B regulates synaptotagmin 1 by direct interaction.</fullName>
                </names>
                <bibref>
                    <xref>
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                <hostOrganismList>
                    <hostOrganism ncbiTaxId="10090">
                        <names>
                            <shortLabel>mouse</shortLabel>
                            <fullName>Mus musculus</fullName>
                            <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                        </names>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>coip</shortLabel>
                        <fullName>coimmunoprecipitation</fullName>
                        <alias typeAc="MI:0303" type="go synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">CoIp</alias>
                        <alias typeAc="MI:0303" type="go synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:0303" type="go synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">co-immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">CoIp</alias>
                        <alias typeAc="MI:1041" type="synonym">immunoprecipitation</alias>
                        <alias typeAc="MI:1041" type="synonym">Co-IP</alias>
                        <alias typeAc="MI:1041" type="synonym">coip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0019" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>monoclonal western</shortLabel>
                        <fullName>monoclonal antibody western blot</fullName>
                        <alias typeAc="MI:1041" type="synonym">monoclonal western</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0072" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-955" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Lazzell DR., Belizaire R., Thakur P., Sherry DM., Janz R.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">Synapse - Interactions of proteins with an established role in the presynapse.</attribute>
                    <attribute name="journal" nameAc="MI:0885">J. Biol. Chem. (0021-9258)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2004</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="168022">
                <names>
                    <shortLabel>q8jzz9_mouse</shortLabel>
                    <alias typeAc="MI:0301" type="gene name">Sv2b</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="Q8JZZ9" version="TrEMBL_30" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011701"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0015031" secondary="protein transport" version="TrEMBL_91"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016079" secondary="synaptic vesicle exocytosis" version="TrEMBL_91"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0022857" secondary="transmembrane transporter activity" version="TrEMBL_91"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051246" secondary="regulation of protein metabolic process" version="TrEMBL_91"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030285" secondary="integral component of synaptic vesicle membrane" version="TrEMBL_91"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036259"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-466179" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR020846"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>PFWSRKVELINRQLMNSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM</sequence>
            </interactor>
            <interactor id="168023">
                <names>
                    <shortLabel>syt1_mouse</shortLabel>
                    <fullName>Synaptotagmin-1</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Synaptotagmin I</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">p65</alias>
                    <alias typeAc="MI:0301" type="gene name">Syt1</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P46096" version="SP_72" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_033332.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048306" secondary="calcium-dependent protein binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005544" secondary="calcium-dependent phospholipid binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098686" secondary="hippocampal mossy fiber to CA3 synapse" version="SP_201"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5T0S" version="SP_201"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001239270.1"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VFF" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030285" secondary="integral component of synaptic vesicle membrane" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016192" secondary="vesicle-mediated transport" version="SP_201"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSMUSP00000063293" version="SP_201" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007269" secondary="neurotransmitter secretion" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060076" secondary="excitatory synapse" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903305" secondary="regulation of regulated secretory pathway" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000149" secondary="SNARE binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001786" secondary="phosphatidylserine binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030424" secondary="axon" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043229" secondary="intracellular organelle" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014059" secondary="regulation of dopamine secretion" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048791" secondary="calcium ion-regulated exocytosis of neurotransmitter" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051966" secondary="regulation of synaptic transmission, glutamatergic" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" secondary="glutamatergic synapse" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061669" secondary="spontaneous neurotransmitter secretion" version="SP_201"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035892" version="SP_201"/>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-8856828" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031045" secondary="dense core granule" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098746" secondary="fast, calcium ion-dependent exocytosis of neurotransmitter" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017156" secondary="calcium-ion regulated exocytosis" version="SP_201"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-212676" version="SP_201"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_006513509.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005543" secondary="phospholipid binding" version="SP_201"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_017169355.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070382" secondary="exocytic vesicle" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1903861" secondary="positive regulation of dendrite extension" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043005" secondary="neuron projection" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005516" secondary="calmodulin binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051291" secondary="protein heterooligomerization" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042734" secondary="presynaptic membrane" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051592" secondary="response to calcium ion" version="SP_201"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007420" secondary="brain development" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008022" secondary="protein C-terminus binding" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042584" secondary="chromaffin granule membrane" version="SP_201"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5VFE" version="SP_201"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031340" secondary="positive regulation of vesicle fusion" version="SP_201"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MVSASRPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction id="168024">
                <names>
                    <shortLabel>sv2b-syt1-1</shortLabel>
                    <fullName>SV2B interacts with full-length Synaptotagmin 1.</fullName>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-466186" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <experimentList>
                    <experimentRef>168021</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="168025">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-466187" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>168022</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="168026">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-466188" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>168023</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>physical association</shortLabel>
                        <fullName>physical association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="comment" nameAc="MI:0612">A monoclonal antibody directed against the cytoplasmic portion of P46096 was used.</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
