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        <source releaseDate="2015-10-21+01:00">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
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                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
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                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
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                <attribute name="url">http://www.ebi.ac.uk/</attribute>
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        <experimentList>
            <experimentDescription id="1855379">
                <names>
                    <shortLabel>schlenner-2012-1</shortLabel>
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                        <names>
                            <shortLabel>mouse-t-cell</shortLabel>
                            <fullName>Mouse T cell</fullName>
                        </names>
                        <tissue>
                            <names>
                                <shortLabel>t-cell</shortLabel>
                                <fullName>Peripheral blood T-lymphocytes</fullName>
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                <interactionDetectionMethod>
                    <names>
                        <shortLabel>ch-ip</shortLabel>
                        <fullName>chromatin immunoprecipitation assay</fullName>
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                    <names>
                        <shortLabel>primer specific pcr</shortLabel>
                        <fullName>primer specific pcr</fullName>
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                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Schlenner SM., Weigmann B., Ruan Q., Chen Y., von Boehmer H.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">IBD - Inflammatory bowel disease</attribute>
                    <attribute name="exp-modification" nameAc="MI:0627">CD4+CD25− splenocytes; cells were stimulated with TGF-beta, 5 µg/ml anti-CD3 and  anti-CD28.</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">harald_von_boehmer@dfci.harvard.edu</attribute>
                    <attribute name="journal" nameAc="MI:0885">The Journal of experimental medicine</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2012</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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            <interactor id="1855380">
                <names>
                    <shortLabel>foxp3_mouse_gene</shortLabel>
                    <fullName>Forkhead box protein P3</fullName>
                    <alias typeAc="MI:0301" type="gene name">Foxp3</alias>
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                        <shortLabel>gene</shortLabel>
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                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
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            </interactor>
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                    <shortLabel>smad3_mouse</shortLabel>
                    <fullName>Mothers against decapentaplegic homolog 3</fullName>
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                    <alias typeAc="MI:0302" type="gene name synonym">Madh3</alias>
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                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2173789" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031490" secondary="chromatin DNA binding" version="SP_181"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q8BX84" version="SP_66" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q92940" version="SP_66" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060290" secondary="transdifferentiation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001701" secondary="in utero embryonic development" version="SP_181"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14510" version="SP_66" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050678" secondary="regulation of epithelial cell proliferation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048701" secondary="embryonic cranial skeleton morphogenesis" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070412" secondary="R-SMAD binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" secondary="ubiquitin protein ligase binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005160" secondary="transforming growth factor beta receptor binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061767" secondary="negative regulation of lung blood pressure" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045668" secondary="negative regulation of osteoblast differentiation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0017015" secondary="regulation of transforming growth factor beta receptor signaling pathway" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030154" secondary="cell differentiation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050927" secondary="positive regulation of positive chemotaxis" version="SP_181"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-MMU-2173795" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036578" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043565" secondary="sequence-specific DNA binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051098" secondary="regulation of binding" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032332" secondary="positive regulation of chondrocyte differentiation" version="SP_181"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030325" secondary="adrenal gland development" version="SP_181"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013019" version="SP_181"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="10090">
                    <names>
                        <shortLabel>mouse</shortLabel>
                        <fullName>Mus musculus</fullName>
                        <alias typeAc="MI:1041" type="synonym">Mouse</alias>
                    </names>
                </organism>
                <sequence>MSSILPFTPPIVKRLLGWKKGEQNGQEEKWCEKAVKSLVKKLKKTGQLDELEKAITTQNVNTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTNFPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVTYCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVELTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSIRCSSVS</sequence>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-24484-1" id="1855382">
                <names>
                    <shortLabel>smad3-foxp3-2</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-11171314" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-24484-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1855379</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1855383">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-11171317" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1855380</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1855384">
                                <names>
                                    <shortLabel>cns1_enhancer_region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-11171318" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>required to bind</shortLabel>
                                        <fullName>necessary binding region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">required to bind</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0429" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608898" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="1855385">
                        <names>
                            <shortLabel>N/A</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-11171316" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1855381</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">1</attribute>
                    <attribute name="comment" nameAc="MI:0612">Mice lacking the CNS1 binding site (CAGACTGTCTG) of Foxp3 enhancer  did not bind Smad3.</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
