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    <entry>
        <source releaseDate="2015-01-22Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
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                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
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                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="1771700">
                <names>
                    <shortLabel>jia-2012-1</shortLabel>
                    <fullName>Tissue factor/activated factor VIIa induces matrix metalloproteinase-7 expression through activation of c-Fos via ERK1/2 and p38 MAPK signaling pathways in human colon cancer cell.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="22076613" refType="primary-reference" refTypeAc="MI:0358"/>
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                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10056597" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23682" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-lovo</shortLabel>
                            <fullName>Homo sapiens colon adenocarcinoma cell line lovo</fullName>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>lovo</shortLabel>
                                <fullName>colon adenocarcinoma cell line lovo</fullName>
                            </names>
                            <xref>
                                <primaryRef db="brenda" dbAc="MI:0864" id="BTO:0000666" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10056594" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </cellType>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>ch-ip</shortLabel>
                        <fullName>chromatin immunoprecipitation assay</fullName>
                        <alias typeAc="MI:1041" type="synonym">ch-ip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0402" refType="identity" refTypeAc="MI:0356"/>
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                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>primer specific pcr</shortLabel>
                        <fullName>primer specific pcr</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0088" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-967" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Jia Z.C., Wan Y.L., Tang J.Q., Dai Y., Liu Y.C., Wang X., Zhu J.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">IBD - Inflammatory bowel disease</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">wan@bjmu.edu.cn,doc-tjq@hotmail.com</attribute>
                    <attribute name="journal" nameAc="MI:0885">Int J Colorectal Dis (0179-1958)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2012</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="1771701">
                <names>
                    <shortLabel>fos_human</shortLabel>
                    <fullName>Proto-oncogene c-Fos</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Cellular oncogene fos</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">G0/G1 switch regulatory protein 7</alias>
                    <alias typeAc="MI:0301" type="gene name">FOS</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">G0S7</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P01100" version="SP_94" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000837" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001228" secondary="DNA-binding transcription activator activity, RNA polymerase II-specific" version="SP_237"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6785807" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035914" secondary="skeletal muscle cell differentiation" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071276" secondary="cellular response to cadmium ion" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060395" secondary="SMAD protein signal transduction" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_237"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004827" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" secondary="chromatin" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035902" secondary="response to immobilization stress" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_237"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2871796" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030431" secondary="sleep" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045672" secondary="positive regulation of osteoclast differentiation" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009636" secondary="response to toxic substance" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051591" secondary="response to cAMP" version="SP_237"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009629" secondary="response to gravity" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1990837" secondary="sequence-specific double-stranded DNA binding" version="SP_237"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007565" secondary="female pregnancy" version="SP_237"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009409" secondary="response to cold" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032570" secondary="response to progesterone" version="SP_237"/>
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                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000170345" version="SP_237" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901216" secondary="positive regulation of neuron death" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" secondary="inflammatory response" version="SP_237"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_005243.1"/>
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                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035994" secondary="response to muscle stretch" version="SP_237"/>
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                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1S9K" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" secondary="transcription cis-regulatory region binding" version="SP_237"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000303562" version="SP_237" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" secondary="DNA-binding transcription factor activity" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902895" secondary="positive regulation of pri-miRNA transcription by RNA polymerase II" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0009416" secondary="response to light stimulus" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_237"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_237"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9634638" version="SP_237"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K4E2" version="SP_172" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR029816" version="SP_237"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL</sequence>
            </interactor>
            <interactor id="1771702">
                <names>
                    <shortLabel>mmp7_human_gene</shortLabel>
                    <fullName>Matrilysin (MMP7) human gene</fullName>
                </names>
                <xref>
                    <primaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000137673" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10056592" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>gene</shortLabel>
                        <fullName>gene</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0250" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000704" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-706030" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-23682-1" id="1771703">
                <names>
                    <shortLabel>fos-mmp7-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10056607" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23682-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1771700</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1771704">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-10056609" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1771701</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                    <participant id="1771705">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-10056610" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1771702</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1771706">
                                <names>
                                    <shortLabel>promoter region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10056611" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 2c</attribute>
                    <attribute name="agonist" nameAc="MI:0625">human Coagulation factor VIIa (FVIIa) (P08709) (100nM for 2 hours)</attribute>
                    <attribute name="causality statement">P08709 increases binding of P01100 to ENSG00000137673</attribute>
                    <attribute name="causality statement">P08709 indirectly increases expression at RNA level of ENSG00000137673</attribute>
                    <attribute name="causality statement">P08709 indirectly increases expression at protein level of ENSG00000137673</attribute>
                    <attribute name="causality statement">P01100 increases expression at protein level of ENSG00000137673</attribute>
                    <attribute name="causality statement">P08709 indirectly increases expression at protein level of P01100</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
