IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ zhao-2011e-1 An NF-κB p65-cIAP2 link is necessary for mediating resistance to TNF-α induced cell death in gliomas. human-u251 Homo sapiens u251 U2521 glioblastoma cell line ch-ip chromatin immunoprecipitation assay ch-ip primer specific pcr primer specific pcr Zhao X., Laver T., Hong S.W., Twitty G.B., Devos A., Devos M., Benveniste E.N., Nozell S.E. IBD - Inflammatory bowel disease snozell@uab.edu J. Neurooncol. (0167-594X) 2011 Only protein-protein interactions imex curation birc3_human_gene Human BIRC3 gene gene gene human Homo sapiens Human tf65_human Transcription factor p65 Nuclear factor NF-kappa-B p65 subunit RELA NFKB3 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 protein protein human Homo sapiens Human MDELFPLIFPAEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGFYEAELCPDRCIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFQVPIEEQRGDYDLNAVRLCFQVTVRDPSGRPLRLPPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPSRSSASVPKPAPQPYPFTSSLSTINYDEFPTMVFPSGQISQASALAPAPPQVLPQAPAPAPAPAMVSALAQAPAPVPVLAPGPPQAVAPPAPKPTQAGEGTLSEALLQLQFDDEDLGALLGNSTDPAVFTDLASVDNSEFQQLLNQGIPVAPHTTEPMLMEYPEAITRLVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLSQISS rela-birc3-1 1762662 n/a 1762663 unspecified role unspecified role prey prey promoter region binding region binding-associated region binding region undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false n/a 1762664 unspecified role unspecified role bait bait association association false false false Fig. 3c P01375 (Tumor necrosis factor alpha (TNF-alpha)) No cIAP-2 promoter DNA co-precipitated with anti-p65 antibody from cells not treated with TNF-alpha. Q04206 increases expression at RNA level of ENSG00000023445 Q04206 increases expression at protein level of ENSG00000023445 P01375 increases binding of Q04206 to ENSG00000023445 P01375 indirectly increases expression at RNA level of ENSG00000023445 P01375 indirectly increases expression at protein level of ENSG00000023445