<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<entrySet level="2" version="5" minorVersion="4" xsi:schemaLocation="http://psi.hupo.org/mi/mif http://psidev.sourceforge.net/mi/rel25/src/MIF254.xsd" xmlns="http://psi.hupo.org/mi/mif" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <entry>
        <source releaseDate="2015-02-25Z">
            <names>
                <shortLabel>IntAct</shortLabel>
                <fullName>European Bioinformatics Institute</fullName>
                <alias typeAc="MI:1041" type="synonym">IntAct</alias>
                <alias typeAc="MI:1041" type="synonym">intact</alias>
            </names>
            <bibref>
                <xref>
                    <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
            </bibref>
            <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
            </xref>
            <attributeList>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
                <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
                <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
                <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
                <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
                <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
                <attribute name="url">http://www.ebi.ac.uk/</attribute>
            </attributeList>
        </source>
        <experimentList>
            <experimentDescription id="1773409">
                <names>
                    <shortLabel>jiang-2008-1</shortLabel>
                    <fullName>Upregulation of survivin by leptin/STAT3 signaling in MCF-7 cells.</fullName>
                </names>
                <bibref>
                    <xref>
                        <primaryRef db="pubmed" dbAc="MI:0446" id="18242580" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </bibref>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062017" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23690" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <hostOrganismList>
                    <hostOrganism ncbiTaxId="9606">
                        <names>
                            <shortLabel>human-mcf7</shortLabel>
                            <fullName>Homo sapiens  mammary carcinoma cells</fullName>
                        </names>
                        <cellType>
                            <names>
                                <shortLabel>mcf7</shortLabel>
                                <fullName>mammary carcinoma cells</fullName>
                            </names>
                            <xref>
                                <primaryRef db="cell ontology" dbAc="MI:0831" id="CLO:0007606" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="IA:0057" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="mint" dbAc="MI:0471" id="MINT-6597532" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="cabri" dbAc="MI:0246" id="ACC 115" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-307621" refType="identity" refTypeAc="MI:0356"/>
                            </xref>
                        </cellType>
                    </hostOrganism>
                </hostOrganismList>
                <interactionDetectionMethod>
                    <names>
                        <shortLabel>ch-ip</shortLabel>
                        <fullName>chromatin immunoprecipitation assay</fullName>
                        <alias typeAc="MI:1041" type="synonym">ch-ip</alias>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0402" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-705656" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="12054902" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactionDetectionMethod>
                <participantIdentificationMethod>
                    <names>
                        <shortLabel>primer specific pcr</shortLabel>
                        <fullName>primer specific pcr</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0088" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-967" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </participantIdentificationMethod>
                <attributeList>
                    <attribute name="author-list" nameAc="MI:0636">Jiang H., Yu J., Guo H., Song H., Chen S.</attribute>
                    <attribute name="dataset" nameAc="MI:0875">IBD - Inflammatory bowel disease</attribute>
                    <attribute name="contact-email" nameAc="MI:0634">sthisci@yahoo.com</attribute>
                    <attribute name="journal" nameAc="MI:0885">Biochem. Biophys. Res. Commun. (0006-291X)</attribute>
                    <attribute name="publication year" nameAc="MI:0886">2008</attribute>
                    <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
                    <attribute name="imex curation" nameAc="MI:0959"/>
                    <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
                </attributeList>
            </experimentDescription>
        </experimentList>
        <interactorList>
            <interactor id="1773410">
                <names>
                    <shortLabel>birc5_human_gene</shortLabel>
                    <fullName>Baculoviral IAP repeat-containing protein 5 gene</fullName>
                </names>
                <xref>
                    <primaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000089685" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-6558349" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>gene</shortLabel>
                        <fullName>gene</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0250" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000704" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-706030" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
            </interactor>
            <interactor id="1773411">
                <names>
                    <shortLabel>stat3_human</shortLabel>
                    <fullName>Signal transducer and activator of transcription 3</fullName>
                    <alias typeAc="MI:0302" type="gene name synonym">Acute-phase response factor</alias>
                    <alias typeAc="MI:0301" type="gene name">STAT3</alias>
                    <alias typeAc="MI:0302" type="gene name synonym">APRF</alias>
                </names>
                <xref>
                    <primaryRef db="uniprotkb" dbAc="MI:0486" id="P40763" version="SP_84" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005634" secondary="nucleus" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005743" secondary="mitochondrial inner membrane" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006355" secondary="regulation of transcription, DNA-templated" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030335" secondary="positive regulation of cell migration" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NJS" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008967" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042803" secondary="protein homodimerization activity" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_644805.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000981" secondary="DNA-binding transcription factor activity, RNA polymerase II-specific" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019953" secondary="sexual reproduction" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032355" secondary="response to estradiol" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0043434" secondary="response to peptide hormone" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001217" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003677" secondary="DNA binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005102" secondary="signaling receptor binding" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012345" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010730" secondary="negative regulation of hydrogen peroxide biosynthetic process" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0014069" secondary="postsynaptic density" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9674555" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9705462" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007259" secondary="receptor signaling pathway via JAK-STAT" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8984722" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044321" secondary="response to leptin" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008134" secondary="transcription factor binding" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1266695" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008285" secondary="negative regulation of cell population proliferation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035259" secondary="glucocorticoid receptor binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042593" secondary="glucose homeostasis" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-982772" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006953" secondary="acute-phase response" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042127" secondary="regulation of cell population proliferation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" secondary="plasma membrane" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072540" secondary="T-helper 17 cell lineage commitment" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000264657" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007399" secondary="nervous system development" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR015988" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031490" secondary="chromatin DNA binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045747" secondary="positive regulation of Notch signaling pathway" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001171" secondary="positive regulation of ATP biosynthetic process" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045648" secondary="positive regulation of erythrocyte differentiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010628" secondary="positive regulation of gene expression" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" secondary="regulation of transcription by RNA polymerase II" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902728" secondary="positive regulation of growth factor dependent skeletal muscle satellite cell proliferation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019903" secondary="protein phosphatase binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" secondary="cytosol" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6TLC" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000467985" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060019" secondary="radial glial cell differentiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019901" secondary="protein kinase binding" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5U5S" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013801" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1901215" secondary="negative regulation of neuron death" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000980" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1904685" secondary="positive regulation of metalloendopeptidase activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001659" secondary="temperature homeostasis" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005654" secondary="nucleoplasm" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9670439" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060397" secondary="growth hormone receptor signaling pathway via JAK-STAT" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001754" secondary="eye photoreceptor cell differentiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007568" secondary="aging" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032731" secondary="positive regulation of interleukin-1 beta production" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0071407" secondary="cellular response to organic cyclic compound" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9707564" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0016310" secondary="phosphorylation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042755" secondary="eating behavior" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032870" secondary="cellular response to hormone stimulus" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905564" secondary="positive regulation of vascular endothelial cell proliferation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051092" secondary="positive regulation of NF-kappaB transcription factor activity" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020958" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1839117" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042789" secondary="mRNA transcription by RNA polymerase II" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032755" secondary="positive regulation of interleukin-6 production" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2001223" secondary="negative regulation of neuron migration" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1902895" secondary="positive regulation of pri-miRNA transcription by RNA polymerase II" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1059683" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" secondary="identical protein binding" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6NUQ" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_998827.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2559582" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2892247" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000978" secondary="RNA polymerase II cis-regulatory region sequence-specific DNA binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0048708" secondary="astrocyte differentiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" secondary="glutamatergic synapse" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007179" secondary="transforming growth factor beta receptor signaling pathway" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046983" secondary="protein dimerization activity" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000504184" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006954" secondary="inflammatory response" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0051726" secondary="regulation of cell cycle" version="SP_231"/>
                    <secondaryRef db="mint" dbAc="MI:0471" id="P40763" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0098685" secondary="Schaffer collateral - CA1 synapse" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045944" secondary="positive regulation of transcription by RNA polymerase II" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070102" secondary="interleukin-6-mediated signaling pathway" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="K7ENL3" version="SP_162" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR035855" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q9BW54" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8983432" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-390471" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0035591" secondary="signaling adaptor activity" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9616222" version="SP_231"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-518675" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0001228" secondary="DNA-binding transcription activator activity, RNA polymerase II-specific" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-1433557" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000168610" version="SP_231" refType="gene"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0046902" secondary="regulation of mitochondrial membrane permeability" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0097009" secondary="energy homeostasis" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000637" secondary="positive regulation of gene silencing by miRNA" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="NP_003141.2"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6QHD" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000785" secondary="chromatin" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000635" secondary="negative regulation of primary miRNA processing" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016880461.1"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8875791" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000264657" version="SP_231" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000122" secondary="negative regulation of transcription by RNA polymerase II" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6785807" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045820" secondary="negative regulation of glycolytic process" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198745" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K7B8" version="SP_131" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006952" secondary="defense response" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" secondary="cytoplasm" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" secondary="signal transduction" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032733" secondary="positive regulation of interleukin-10 production" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-186763" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9673770" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:2000737" secondary="negative regulation of stem cell differentiation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0050804" secondary="modulation of chemical synaptic transmission" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-111453" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-452723" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0010507" secondary="negative regulation of autophagy" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0090575" secondary="RNA polymerase II transcription regulator complex" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0005667" secondary="transcription regulator complex" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000678906" version="SP_231" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060259" secondary="regulation of feeding behavior" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0070878" secondary="primary miRNA binding" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000588969" version="SP_231" refType="transcript"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257673.2"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8854691" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020956" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0030522" secondary="intracellular receptor signaling pathway" version="SP_231"/>
                    <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O14916" version="SP_84" refType="secondary-ac" refTypeAc="MI:0360"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032757" secondary="positive regulation of interleukin-8 production" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036860" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1900017" secondary="positive regulation of cytokine production involved in inflammatory response" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045471" secondary="response to ethanol" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523448.1"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000678960" version="SP_231" refType="transcript"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013799" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0044320" secondary="cellular response to leptin stimulus" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0004879" secondary="nuclear receptor activity" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8985947" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:1905618" secondary="positive regulation of miRNA mediated inhibition of translation" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019221" secondary="cytokine-mediated signaling pathway" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036535" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0032760" secondary="positive regulation of tumor necrosis factor production" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9020933" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9673767" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_005257674.2"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0060396" secondary="growth hormone receptor signaling pathway" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-2586552" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-6783783" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0006606" secondary="protein import into nucleus" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000678044" version="SP_231" refType="transcript"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0042493" secondary="response to drug" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0040014" secondary="regulation of multicellular organism growth" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-8849474" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000503181" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0099527" secondary="postsynapse to nucleus signaling pathway" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0033210" secondary="leptin-mediated signaling pathway" version="SP_231"/>
                    <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5AX3" version="SP_231"/>
                    <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000503102" version="SP_231" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0000976" secondary="transcription cis-regulatory region binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0061629" secondary="RNA polymerase II-specific DNA-binding transcription factor binding" version="SP_231"/>
                    <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013800" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0031730" secondary="CCR5 chemokine receptor binding" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0072538" secondary="T-helper 17 type immune response" version="SP_231"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523447.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045766" secondary="positive regulation of angiogenesis" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0045893" secondary="positive regulation of transcription, DNA-templated" version="SP_231"/>
                    <secondaryRef db="dip" dbAc="MI:0465" id="DIP-33584N"/>
                    <secondaryRef db="refseq" dbAc="MI:0481" id="XP_016880464.1"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0003700" secondary="DNA-binding transcription factor activity" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0008283" secondary="cell population proliferation" version="SP_231"/>
                    <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9008059" version="SP_231"/>
                    <secondaryRef db="go" dbAc="MI:0448" id="GO:0019827" secondary="stem cell population maintenance" version="SP_231"/>
                </xref>
                <interactorType>
                    <names>
                        <shortLabel>protein</shortLabel>
                        <fullName>protein</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactorType>
                <organism ncbiTaxId="9606">
                    <names>
                        <shortLabel>human</shortLabel>
                        <fullName>Homo sapiens</fullName>
                        <alias typeAc="MI:1041" type="synonym">Human</alias>
                    </names>
                </organism>
                <sequence>MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM</sequence>
                <attributeList>
                    <attribute name="crc64">6C00632211C8012D</attribute>
                </attributeList>
            </interactor>
        </interactorList>
        <interactionList>
            <interaction imexId="IM-23690-1" id="1773412">
                <names>
                    <shortLabel>stat3-birc5-1</shortLabel>
                </names>
                <xref>
                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062032" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="imex" dbAc="MI:0670" id="IM-23690-1" refType="imex-primary" refTypeAc="MI:0662"/>
                </xref>
                <experimentList>
                    <experimentRef>1773409</experimentRef>
                </experimentList>
                <participantList>
                    <participant id="1773413">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062035" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1773410</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>prey</shortLabel>
                                    <fullName>prey</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                        <featureList>
                            <feature id="1773414">
                                <names>
                                    <shortLabel>promoter region</shortLabel>
                                </names>
                                <xref>
                                    <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062037" refType="identity" refTypeAc="MI:0356"/>
                                </xref>
                                <featureType>
                                    <names>
                                        <shortLabel>binding region</shortLabel>
                                        <fullName>binding-associated region</fullName>
                                        <alias typeAc="MI:1041" type="synonym">binding region</alias>
                                    </names>
                                    <xref>
                                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0117" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456493" refType="identity" refTypeAc="MI:0356"/>
                                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                    </xref>
                                </featureType>
                                <featureRangeList>
                                    <featureRange>
                                        <startStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </startStatus>
                                        <endStatus>
                                            <names>
                                                <shortLabel>undetermined</shortLabel>
                                                <fullName>undetermined sequence position</fullName>
                                                <alias typeAc="MI:1041" type="synonym">undetermined</alias>
                                            </names>
                                            <xref>
                                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0339" refType="identity" refTypeAc="MI:0356"/>
                                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-448295" refType="identity" refTypeAc="MI:0356"/>
                                            </xref>
                                        </endStatus>
                                        <isLink>false</isLink>
                                    </featureRange>
                                </featureRangeList>
                            </feature>
                        </featureList>
                    </participant>
                    <participant id="1773415">
                        <names>
                            <shortLabel>n/a</shortLabel>
                        </names>
                        <xref>
                            <primaryRef db="intact" dbAc="MI:0469" id="EBI-10062034" refType="identity" refTypeAc="MI:0356"/>
                        </xref>
                        <interactorRef>1773411</interactorRef>
                        <biologicalRole>
                            <names>
                                <shortLabel>unspecified role</shortLabel>
                                <fullName>unspecified role</fullName>
                            </names>
                            <xref>
                                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                            </xref>
                        </biologicalRole>
                        <experimentalRoleList>
                            <experimentalRole>
                                <names>
                                    <shortLabel>bait</shortLabel>
                                    <fullName>bait</fullName>
                                </names>
                                <xref>
                                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                                </xref>
                            </experimentalRole>
                        </experimentalRoleList>
                    </participant>
                </participantList>
                <interactionType>
                    <names>
                        <shortLabel>association</shortLabel>
                        <fullName>association</fullName>
                    </names>
                    <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0914" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813191" refType="identity" refTypeAc="MI:0356"/>
                    </xref>
                </interactionType>
                <modelled>false</modelled>
                <intraMolecular>false</intraMolecular>
                <negative>false</negative>
                <attributeList>
                    <attribute name="figure legend" nameAc="MI:0599">Fig. 4b</attribute>
                    <attribute name="agonist" nameAc="MI:0625">leptin (10nM for 30 minutes)</attribute>
                    <attribute name="agonist" nameAc="MI:0625">interleukin-6 (IL-6) (20 ng/ml for 30 minutes)</attribute>
                    <attribute name="causality statement">P40763 increases expression at RNA level of ENSG00000089685</attribute>
                    <attribute name="causality statement">P40763 increases expression at protein level of ENSG00000089685</attribute>
                </attributeList>
            </interaction>
        </interactionList>
    </entry>
</entrySet>
