bhf-ucl von-2017-4 in vitro In vitro filter binding filter binding Filter overlay assay Filter overlay assay predetermined predetermined participant predetermined von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance Proteins are believed to be E.coli expressed apart from XCL2 which was probably expressed from the 293 cell line. chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-3 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance All proteins are believed to have been expressed in E.coli chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-2 in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-6 in vitro In vitro solution nmr solution state nmr solution state nmr solution nmr predetermined predetermined participant predetermined von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-10 in vitro In vitro facs fluorescence-activated cell sorting FACS Flow cytometry facs tag fluorescence tag visualisation by fluorescence tag fluorescence von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-7 mouse-dendritic cell Mouse dendritic cell dendritic_cell dendritic cell pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-1 mouse-endothelium Mus musculus endothelium Endothelial cells [endothelium] pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-5 mouse-lymphnode mouse lymph node Mouse lymph gland lymph node lymph node Any of the rounded masses of lymphoid tissue that are surrounded by a capsule of connective tissue, are distributed along the lymphatic vessels, and contain numerous lymphocytes which filter the flow of lymph. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance para-aortic lymph nodes chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-8 human-coronary artery human coronary artery Human coronary artery Either of two arteries that arise one from the left and one from the right side of the aorta immediately above the semilunar valves and supply the tissues of the heart itself. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance Intima and adventitia of human coronary arteries with advanced atherosclerosis. chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation von-2017-9 mouse_aortic_root mouse_aortic_root Mouse aortic root aortic_root aortic root The part of the aorta attached to the atrioventricular fibrous rings and myocardium. pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection von Hundelshausen P., Agten SM., Eckardt V., Blanchet X., Schmitt MM., Ippel H., Neideck C., Bidzhekov K., Leberzammer J., Wichapong K., Faussner A., Drechsler M., Grommes J., van Geffen JP., Li H., Ortega-Gomez A., Megens RT., Naumann R., Dijkgraaf I., Nicolaes GA., Döring Y., Soehnlein O., Lutgens E., Heemskerk JW., Koenen RR., Mayo KH., Hackeng TM., Weber C. Cardiac - Interactions involving cardiac related proteins Interactions involving VREYX4 and OPRAH have not been annotated as these are synthetic proteins and results obtained are of dubious biological relevance chweber@med.lmu.de Science translational medicine 2017 Only protein-protein interactions imex curation imex curation ccl5_human C-C motif chemokine 5 CCL5 D17S136E SCYA5 EoCP Eosinophil chemotactic cytokine SIS-delta Small-inducible cytokine A5 T cell-specific protein P228 T-cell-specific protein RANTES protein protein human Homo sapiens Human MKVSAAALAVILIATALCAPASASPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS ccl13_human C-C motif chemokine 13 Small-inducible cytokine A13 Monocyte chemoattractant protein 4 Monocyte chemotactic protein 4 CK-beta-10 NCC-1 CCL13 MCP4 NCC1 SCYA13 protein protein human Homo sapiens Human MKVSAVLLCLLLMTAAFNPQGLAQPDALNVPSTCCFTFSSKKISLQRLKSYVITTSRCPQKAVIFRTKLGKEICADPKEKWVQNYMKHLGRKAHTLKT ccl2_human C-C motif chemokine 2 CCL2 MCP1 SCYA2 Small-inducible cytokine A2 Monocyte chemoattractant protein 1 Monocyte chemotactic protein 1 Monocyte chemotactic and activating factor Monocyte secretory protein JE HC11 protein protein human Homo sapiens Human MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT ccl15_human C-C motif chemokine 15 CCL15 MIP5 NCC3 SCYA15 Chemokine CC-2 Leukotactin-1 MIP-1 delta Macrophage inflammatory protein 5 Mrp-2b NCC-3 Small-inducible cytokine A15 protein protein human Homo sapiens Human MKVSVAALSCLMLVAVLGSQAQFINDAETELMMSKLPLENPVVLNSFHFAADCCTSYISQSIPCSLMKSYFETSSECSKPGVIFLTKKGRQVCAKPSGPGVQDCMKKLKPYSI ccl26_human C-C motif chemokine 26 CCL26 SCYA26 UNQ216/PRO242 Macrophage inflammatory protein 4-alpha Small-inducible cytokine A26 Eotaxin-3 Thymic stroma chemokine-1 CC chemokine IMAC protein protein human Homo sapiens Human MMGLSLASAVLLASLLSLHLGTATRGSDISKTCCFQYSHKPLPWTWVRSYEFTSNSCSQRAVIFTTKRGKKVCTHPRKKWVQKYISLLKTPKQL mint Chemotactic for eosinophils and basophils. Binds to CCR3 ccl16_human C-C motif chemokine 16 CCL16 Chemokine CC-4 Chemokine LEC IL-10-inducible chemokine ILINCK LCC-1 Liver-expressed chemokine Lymphocyte and monocyte chemoattractant Monotactin-1 NCC-4 NCC4 SCYA16 Small-inducible cytokine A16 protein protein human Homo sapiens Human MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNCHLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ ccl17_human C-C motif chemokine 17 CCL17 SCYA17 TARC CC chemokine TARC Small-inducible cytokine A17 Thymus and activation-regulated chemokine protein protein human Homo sapiens Human MAPLKMLALVTLLLGASLQHIHAARGTNVGRECCLEYFKGAIPLRKLKTWYQTSEDCSRDAIVFVTVQGRAICSDPNNKRVKNAVKYLQSLERS ccl20_human C-C motif chemokine 20 CCL20 LARC MIP3A SCYA20 Beta-chemokine exodus-1 CC chemokine LARC Liver and activation-regulated chemokine Macrophage inflammatory protein 3 alpha Small-inducible cytokine A20 protein protein human Homo sapiens Human MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM ccl21_human C-C motif chemokine 21 Small-inducible cytokine A21 Beta-chemokine exodus-2 6Ckine Secondary lymphoid-tissue chemokine CCL21 SCYA21 UNQ784/PRO1600 protein protein human Homo sapiens Human MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP ccl24_human C-C motif chemokine 24 CCL24 MPIF2 SCYA24 CK-beta-6 Eosinophil chemotactic protein 2 Myeloid progenitor inhibitory factor 2 Small-inducible cytokine A24 protein protein human Homo sapiens Human MAGLMTIVTSLLFLGVCAHHIIPTGSVVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQFCGDPKQEWVQRYMKNLDAKQKKASPRARAVAVKGPVQRYPGNQTTC ccl27_human C-C motif chemokine 27 CCL27 CC chemokine ILC Cutaneous T-cell-attracting chemokine ESkine IL-11 R-alpha-locus chemokine ILC SCYA27 Skinkine Small-inducible cytokine A27 protein protein human Homo sapiens Human MKGPPTFCSLLLLSLLLSPDPTAAFLLPPSTACCTQLYRKPLSDKLLRKVIQVELQEADGDCHLQAFVLHLAQRSICIHPQNPSLSQWFEHQERKLHGTLPKLNFGMLRKMG ccl28_human C-C motif chemokine 28 Mucosae-associated epithelial chemokine CCL28 SCYA28 Small-inducible cytokine A28 Protein CCK1 protein protein human Homo sapiens Human MQQRGLAIVALAVCAALHASEAILPIASSCCTEVSHHISRRLLERVNMCRIQRADGDCDLAAVILHVKRRRICVSPHNHTVKQWMKVQAAKKNGKGNVCHRKKHHGKRNSNRAHQGKHETYGHKTPY Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner mint xcl1_human Lymphotactin XCL1 ATAC C motif chemokine 1 Cytokine SCM-1 LTN Lymphotaxin SCM-1-alpha SCYC1 Small-inducible cytokine C1 XC chemokine ligand 1 protein protein human Homo sapiens Human MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG cxcl2_human C-X-C motif chemokine 2 CXCL2 GRO2 GROB MIP2A SCYB2 Macrophage inflammatory protein 2-alpha Growth-regulated protein beta protein protein human Homo sapiens Human MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSVKVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN plf4_human Platelet factor 4 PF4 CXCL4 SCYB4 C-X-C motif chemokine 4 Oncostatin-A Iroplact protein protein human Homo sapiens Human MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES cxcl7_human Platelet basic protein Small-inducible cytokine B7 Leukocyte-derived growth factor Macrophage-derived growth factor CXCL7 C-X-C motif chemokine 7 PPBP CTAP3 SCYB7 TGB1 THBGB1 protein protein human Homo sapiens Human MSLRLDTTPSCNSARPLHALQVLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLEVIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD cxcl9_human C-X-C motif chemokine 9 CXCL9 CMK MIG SCYB9 Gamma-interferon-induced monokine Monokine induced by interferon-gamma Small-inducible cytokine B9 protein protein human Homo sapiens Human MKKSGVLFLLGIILLVLIGVQGTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSRQKKTT cxl10_human C-X-C motif chemokine 10 CXCL10 INP10 SCYB10 Small-inducible cytokine B10 10 kDa interferon gamma-induced protein protein protein human Homo sapiens Human MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP mint Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3 cxl11_human C-X-C motif chemokine 11 CXCL11 ITAC SCYB11 SCYB9B Beta-R1 H174 Interferon gamma-inducible protein 9 Interferon-inducible T-cell alpha chemoattractant Small-inducible cytokine B11 protein protein human Homo sapiens Human MSVKGMAIALAVILCATVVQGFPMFKRGRCLCIGPGVKAVKVADIEKASIMYPSNNCDKIEVIITLKENKGQRCLNPKSKQARLIIKKVERKNF sdf1_human Stromal cell-derived factor 1 CXCL12 SDF1 SDF1A SDF1B C-X-C motif chemokine 12 Intercrine reduced in hepatomas Pre-B cell growth-stimulating factor protein protein human Homo sapiens Human MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM cxl14_human C-X-C motif chemokine 14 MIP2G NJAC SCYB14 Chemokine BRAK MIP-2G Small-inducible cytokine B14 UNQ240/PRO273 PSEC0212 CXCL14 protein protein human Homo sapiens Human MSLLPRRAPPVSMRLLAAALLLLLLALYTARVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE ccl8_human C-C motif chemokine 8 CCL8 MCP2 SCYA10 SCYA8 HC14 Monocyte chemoattractant protein 2 Monocyte chemotactic protein 2 Small-inducible cytokine A8 protein protein human Homo sapiens Human MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP ccl11_human Eotaxin C-C motif chemokine 11 Small-inducible cytokine A11 Eosinophil chemotactic protein CCL11 SCYA11 protein protein human Homo sapiens Human MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP cxcl6_human C-X-C motif chemokine 6 CXCL6 GCP2 SCYB6 Chemokine alpha 3 Granulocyte chemotactic protein 2 Small-inducible cytokine B6 protein protein human Homo sapiens Human MSLPSSRAARVPGPSGSLCALLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTLRVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN il8_human Interleukin-8 Protein 3-10C T-cell chemotactic factor CXCL8 C-X-C motif chemokine 8 Chemokine (C-X-C motif) ligand 8 Emoctakin Granulocyte chemotactic protein 1 IL8 Monocyte-derived neutrophil chemotactic factor Monocyte-derived neutrophil-activating peptide Neutrophil-activating protein 1 protein protein human Homo sapiens Human MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS ccl14_human C-C motif chemokine 14 Small-inducible cytokine A14 Chemokine CC-1/CC-3 HCC-1(1-74) NCC-2 CCL14 NCC2 SCYA14 protein protein human Homo sapiens Human MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN groa_human Growth-regulated alpha protein GRO GRO1 GROA MGSA SCYB1 C-X-C motif chemokine 1 GRO-alpha(1-73) Melanoma growth stimulatory activity Neutrophil-activating protein 3 CXCL1 protein protein human Homo sapiens Human MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN cxcl3_human C-X-C motif chemokine 3 CXCL3 GRO3 GROG SCYB3 GRO-gamma(1-73) Growth-regulated protein gamma Macrophage inflammatory protein 2-beta protein protein human Homo sapiens Human MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSVNVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN cxcl5_human C-X-C motif chemokine 5 CXCL5 ENA-78(1-78) ENA78 Epithelial-derived neutrophil-activating protein 78 Neutrophil-activating peptide ENA-78 SCYB5 Small-inducible cytokine B5 protein protein human Homo sapiens Human MSLLSSRAARVPGPSSSLCALLVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQGVHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN ccl25_human C-C motif chemokine 25 CCL25 SCYA25 TECK Small-inducible cytokine A25 Thymus-expressed chemokine Chemokine TECK protein protein human Homo sapiens Human MNLWLLACLVAGFLGAWAPAVHTQGVFEDCCLAYHYPIGWAVLRRAWTYRIQEVSGSCNLPAAIFYLPKRHRKVCGNPKSREVQRAMKLLDARNKVFAKLHHNTQTFQAGPHAVKKLSSGNSKLSSSKFSNPISSSKRNVSLLISANSGL mint Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1 ccl18_human C-C motif chemokine 18 CCL18 AMAC1 DCCK1 MIP4 PARC SCYA18 Dendritic cell chemokine 1 Small-inducible cytokine A18 Macrophage inflammatory protein 4 Pulmonary and activation-regulated chemokine CC chemokine PARC Alternative macrophage activation-associated CC chemokine 1 protein protein human Homo sapiens Human MKGLAAALLVLVCTMALCSCAQVGTNKELCCLVYTSWQIPQKFIVDYSETSPQCPKPGVILLTKRGRQICADPNKKWVQKYISDLKLNA ccl19_human C-C motif chemokine 19 CCL19 ELC MIP3B SCYA19 Beta-chemokine exodus-3 CK beta-11 Epstein-Barr virus-induced molecule 1 ligand chemokine Macrophage inflammatory protein 3 beta Small-inducible cytokine A19 protein protein human Homo sapiens Human MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSS pf4v_human Platelet factor 4 variant PF4V1 SCYB4V1 CXCL4V1 PF4var1 PF4alt C-X-C motif chemokine 4 variant CXCL4L1 protein protein human Homo sapiens Human MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES ccl23_human C-C motif chemokine 23 CCL23 MIP3 MPIF1 SCYA23 CK-beta-8 Macrophage inflammatory protein 3 Myeloid progenitor inhibitory factor 1 Small-inducible cytokine A23 protein protein human Homo sapiens Human MKVSVAALSCLMLVTALGSQARVTKDAETEFMMSKLPLENPVLLDRFHATSADCCISYTPRSIPCSLLESYFETNSECSKPGVIFLTKKGRRFCANPSDKQVQVCVRMLKLDTRIKTRKN ccl22_human C-C motif chemokine 22 CCL22 MDC SCYA22 CC chemokine STCP-1 MDC(1-69) Macrophage-derived chemokine Small-inducible cytokine A22 Stimulated T-cell chemotactic protein 1 A-152E5.1 protein protein human Homo sapiens Human MDRLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYRLPLRVVKHFYWTSDSCPRPGVVLLTFRDKEICADPRVPWVKMILNKLSQ xcl2_human Cytokine SCM-1 beta XCL2 C motif chemokine 2 SCYC2 XC chemokine ligand 2 protein protein human Homo sapiens Human MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG ccl7_human C-C motif chemokine 7 Small-inducible cytokine A7 Monocyte chemoattractant protein 3 Monocyte chemotactic protein 3 NC28 CCL7 MCP3 SCYA7 SCYA6 protein protein human Homo sapiens Human MKASAALLCLLLTAAAFSPQGLAQPVGINTSTTCCYRFINKKIPKQRLESYRRTTSSHCPREAVIFKTKLDKEICADPTQKWVQDFMKHLDKKTQTPKL cxl17_human C-X-C motif chemokine 17 CXCL17 VCC1 Dendritic cell and monocyte chemokine-like protein VEGF coregulated chemokine 1 UNQ473/PRO842 protein protein human Homo sapiens Human MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL cc4l_human C-C motif chemokine 4-like CCL4L1 CCL4L2 CCL4L LAG1 Lymphocyte activation gene 1 protein Macrophage inflammatory protein 1-beta Monocyte adherence-induced protein 5-alpha SCYA4L1 SCYA4L2 Small-inducible cytokine A4-like protein protein human Homo sapiens Human MKLCVTVLSLLVLVAAFCSLALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADPSESWVQEYVYDLELN ccl1_human C-C motif chemokine 1 CCL1 SCYA1 Small-inducible cytokine A1 T lymphocyte-secreted protein I-309 protein protein human Homo sapiens Human MQIITTALVCLLLAGMWPEDVDSKSMQVPFSRCCFSFAEQEIPLRAILCYRNTSSICSNEGLIFKLKRGKEACALDTVGWVQRHRKMLRHCPSKRK cxl13_human C-X-C motif chemokine 13 Small-inducible cytokine B13 B lymphocyte chemoattractant CXC chemokine BLC B cell-attracting chemokine 1 CXCL13 BCA1 BLC SCYB13 Angie protein protein human Homo sapiens Human MKFISTSLLLMLLVSSLSPVQGVLEVYYTSLRCRCVQESSVFIPRRFIDRIQILPRGNGCPRKEIIVWKKNKSIVCVDPQAEWIQRMMEVLRKRSSSTLPVPVFKRKIP ccl5 protein protein human Homo sapiens Human p13501-pro_0000005175 C-C motif chemokine 5 Eosinophil chemotactic cytokine SIS-delta Small-inducible cytokine A5 T cell-specific protein P228 T-cell-specific protein RANTES EoCP D17S136E SCYA5 CCL5 protein protein human Homo sapiens Human SPYSSDTTPCCFAYIARPLPRAHIKEYFYTSGKCSNPAVVFVTRKNRQVCANPEKKWVREYINSLEMS 24 91 p02776-pro_0000351217 Platelet factor 4, short form C-X-C motif chemokine 4 Iroplact Oncostatin-A PF4 CXCL4 SCYB4 protein protein human Homo sapiens Human SQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES 48 101 ccr5_human C-C chemokine receptor type 5 HIV-1 fusion coreceptor CHEMR13 CCR5 CMKBR5 protein protein human Homo sapiens Human MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL ccr4_human C-C chemokine receptor type 4 CCR4 CMKBR4 K5-5 protein protein human Homo sapiens Human MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVVLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVGFYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYTERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKAVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL mint High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival ccr1_human C-C chemokine receptor type 1 Macrophage inflammatory protein 1-alpha receptor RANTES-R HM145 LD78 receptor CCR1 CMKBR1 CMKR1 SCYAR1 protein protein human Homo sapiens Human METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF ccr5_mouse C-C chemokine receptor type 5 MIP-1 alpha receptor Ccr5 Cmkbr5 protein protein mouse Mus musculus Mouse MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL f6r5p4_mouse C-C motif chemokine Ccl17 protein protein mouse Mus musculus Mouse MKTFTSAFGTMRSLQMLLLAALLLGTFLQHARAARATNVGRECCLDYFKGAIPIRKLVSWYKTSVECSRDAIVFLTVQGKLICADPKDKHVKKAIRLVKNPRP ccl5_mouse C-C motif chemokine 5 MuRantes SIS-delta Small-inducible cytokine A5 T-cell-specific protein RANTES Ccl5 Scya5 protein protein mouse Mus musculus Mouse MKISAAALTIILTAAALCTPAPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS ccr4_mouse C-C chemokine receptor type 4 Ccr4 Cmkbr4 protein protein mouse Mus musculus Mouse MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPPLYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQWVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLITWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIMLFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDCTLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDFLQVYSADMSSSSYTQSTVDHDFRDAL plf4_mouse Platelet factor 4 Pf4 Cxcl4 Scyb4 C-X-C motif chemokine 4 protein protein mouse Mus musculus Mouse MSVAAVFRGLRPSPELLLLGLLFLPAVVAVTSAGPEESDGDLSCVCVKTISSGIHLKHITSLEVIKAGRHCAVPQLIATLKNGRKICLDRQAPLYKKVIKKILES mint Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes ccl13-ccl5-1 3319934 N/A CCL2 3319944 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl15-ccl5-1 3319934 N/A CCL2 3319946 unspecified role unspecified role prey prey purified purified N/A CCL15 3319947 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl5-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CCL2 3319944 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl16-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL16 3319949 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl17-ccl5-6 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl24-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL24 3319953 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl5-2 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl27-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL27 3319954 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl5-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl5-5 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl5-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-ccl5-2 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl5-1 3319934 N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl8-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl6-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CXCL6 3319967 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl8-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CXCL8 3319968 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl8-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl8-1 3319934 N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl11-2 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl14-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CCL14 3319969 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl11-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl1-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL1 3319970 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl3-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL3 3319971 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl11-2 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl5-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL5 3319972 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl6-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL6 3319967 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl11-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl11-1 3319934 N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl13-2 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-ccl13-1 3319934 N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl13-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl13-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl13-1 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl13-2 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-ccl13-1 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl13-1 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl13-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl13-1 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl13-1 3319934 N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl17-2 3319934 N/A CCL17 3319950 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl25-ccl17-1 3319934 N/A CCL25 3319973 unspecified role unspecified role bait bait purified purified N/A CCL17 3319950 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl17-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CCL17 3319950 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-ccl18-1 3319934 N/A CCL18 3319974 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl19-1 3319934 N/A CCL19 3319975 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl17-ccl21-2 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl23-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CCL23 3319977 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl21-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl21-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl21-2 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl21-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl21-1 3319934 N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl14-ccl22-1 3319934 N/A CCL22 3319978 unspecified role unspecified role prey prey purified purified N/A CCL14 3319969 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl22-1 3319934 N/A CCL22 3319978 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl24-2 3319934 N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-ccl24-1 3319934 N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-ccl24-1 3319934 N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl24-1 3319934 N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl24-1 3319934 N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl25-2 3319934 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl25-2 3319934 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl25-1 3319934 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-ccl25-2 3319934 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl26-2 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl17-ccl26-2 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl26-2 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl26-1 3319934 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl27-1 3319934 N/A CCL27 3319954 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-ccl27-1 3319934 N/A CCL27 3319954 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl27-1 3319934 N/A CCL27 3319954 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-ccl27-2 3319934 N/A CCL28 3319954 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl17-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-ccl27-2 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-ccl27-1 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-xcl1-2 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-xcl1-1 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-xcl1-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-xcl1-1 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-xcl1-1 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-xcl1-1 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-xcl1-2 3319934 N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-xcl1-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-xcl2-2 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl7-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CCL7 3319980 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl8-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CCL8 3319965 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-xcl2-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-xcl2-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl3-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL3 3319971 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl5-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL5 3319972 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-xcl2-2 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl17-xcl2-1 3319934 N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified N/A CXCL17 3319981 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl2-1 3319934 N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-cxcl2-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-cxcl2-1 3319934 N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl2-1 3319934 N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-pf4-3 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl25-pf4-1 3319934 N/A CCL25 3319973 unspecified role unspecified role bait bait purified purified N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-pf4-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-pf4-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-pf4-3 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-pf4-1 3319934 N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl4l1-pf4v1-1 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A CCL4L1 3319982 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-pf4v1-1 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-pf4v1-1 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl25-pf4v1-1 3319934 N/A CCL25 3319973 unspecified role unspecified role bait bait purified purified N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-pf4v1-1 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-pf4v1-1 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-pf4v1-2 3319934 N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-cxcl5-1 3319934 N/A CXCL5 3319972 unspecified role unspecified role prey prey purified purified N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl1-cxcl5-1 3319934 N/A CXCL5 3319972 unspecified role unspecified role prey prey purified purified N/A CXCL1 3319970 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-cxcl5-1 3319934 N/A CXCL5 3319972 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl3-cxcl5-1 3319934 N/A CXCL5 3319972 unspecified role unspecified role prey prey purified purified N/A CXCL3 3319971 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl5-1 3319934 N/A CXCL5 3319972 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-cxcl6-2 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl7-cxcl6-1 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CCL7 3319980 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl1-cxcl6-1 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CXCL1 3319970 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-cxcl6-1 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl3-cxcl6-1 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CXCL3 3319971 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl6-2 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-cxcl6-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-cxcl6-2 3319934 N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl8-ppbp-1 3319934 N/A CXCL7 3319959 unspecified role unspecified role prey prey purified purified N/A CCL8 3319965 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl6-ppbp-1 3319934 N/A CXCL7 3319959 unspecified role unspecified role prey prey purified purified N/A CXCL6 3319967 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-ppbp-1 3319934 N/A CXCL7 3319959 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-cxcl8-1 3319934 N/A CXCL8 3319968 unspecified role unspecified role prey prey purified purified N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl8-2 3319934 N/A CXCL8 3319968 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-cxcl9-1 3319934 N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl9-1 3319934 N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl9-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl9-2 3319934 N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-cxcl9-1 3319934 N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-cxcl9-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl9-1 3319934 N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl10-2 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl10-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl1-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CCL1 3319983 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl24-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CCL24 3319953 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl25-cxcl11-1 3319934 N/A CCL25 3319973 unspecified role unspecified role bait bait purified purified N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl11-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl11-2 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-cxcl11-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl12-cxcl11-2 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl11-1 3319934 N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-cxcl12-2 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl11-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl12-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-cxcl12-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl12-2 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-cxcl12-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl17-cxcl12-1 3319934 N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) N/A CXCL17 3319981 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl4l1-cxcl13-1 3319934 N/A CXCL13 3319984 unspecified role unspecified role prey prey purified purified N/A CCL4L1 3319982 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-cxcl13-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CXCL13 3319984 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4v1-cxcl13-1 3319934 N/A CXCL13 3319984 unspecified role unspecified role prey prey purified purified N/A CXCL4L1 3319976 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl14-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl14-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl2-cxcl14-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CXCL2 3319957 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl14-2 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ppbp-cxcl14-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CXCL7 3319959 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl14-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl11-cxcl14-1 3319934 N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified N/A CXCL11 3319962 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl2-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL2 3319946 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-cxcl17-2 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl8-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL8 3319965 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl13-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL13 3319945 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl20-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL20 3319951 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl21-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CCL21 3319952 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl25-cxcl17-1 3319934 N/A CCL25 3319973 unspecified role unspecified role bait bait purified purified N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl26-cxcl17-1 3319934 N/A CCL26 3319948 unspecified role unspecified role bait bait purified purified N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl28-cxcl17-1 3319934 N/A CCL28 3319955 unspecified role unspecified role bait bait purified purified N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 xcl1-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A XCL1 3319956 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 pf4-cxcl17-2 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl9-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CXCL9 3319960 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl10-cxcl17-1 3319934 N/A CXCL10 3319961 unspecified role unspecified role bait bait purified purified N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl14-cxcl17-1 3319934 N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified N/A CXCL14 3319964 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl8-cxcl17-2 3319934 N/A CXCL17 3319946 unspecified role unspecified role prey prey purified purified N/A CCL8 3319965 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1i ccl28-ccl11-2 3319934 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL11 3319966 unspecified role unspecified role bait bait purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 cxcl13-ccl28-1 3319934 N/A CXCL13 3319984 unspecified role unspecified role bait bait purified purified N/A CCL28 3319946 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl15-ccl2-1 3319934 N/A CCL15 3319948 unspecified role unspecified role bait bait purified purified N/A CCL2 3319946 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl4l1-cxcl13-2 3319934 N/A CCL4L1 3319982 unspecified role unspecified role bait bait purified purified N/A CXCL13 3319946 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Table S1, Figure 1A, Figure S1 ccl5-ccl2-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL2 3319946 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-ccl5-3 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 B ccl5-ccl8-1 3319935 N/A CCL5 3319985 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL8 3319965 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl11-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-ccl13-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl16-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL16 3319949 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl17-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL17 3319950 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-ccl20-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl21-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl24-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL24 3319953 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ccl25-1 3319935 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 B ccl5-ccl26-1 3319935 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 B ccl5-ccl28-1 3319935 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 B ccl5-xcl1-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-xcl2-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-cxcl2-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-pf4-2 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-cxcl6-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-ppbp-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL7 3319959 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-cxcl9-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-cxcl10-1 3319935 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-cxcl11-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-cxcl12-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 B, Table S2 ccl5-cxcl14-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B ccl5-cxcl17-1 3319935 N/A CCL5 3319944 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 B pf4-ccl2-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL2 3319946 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl5-4 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 C, Table S2 pf4-ccl11-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl13-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl17-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL17 3319950 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl20-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl21-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-ccl25-1 3319935 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 C pf4-ccl26-1 3319935 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 C pf4-ccl28-1 3319935 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 C pf4-xcl1-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl2-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL2 3319957 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl2-2 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-pf4-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 C pf4-cxcl6-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl8-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL8 3319968 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 C, Table S2 pf4-cxcl9-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl10-1 3319935 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 C pf4-cxcl11-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl12-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 C, Table S2 pf4-cxcl14-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C pf4-cxcl17-1 3319935 N/A CXCL4 3319958 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 C cxcl12-ccl5-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 D, Table S2 cxcl12-ccl11-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL11 3319966 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl13-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL13 3319945 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl20-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL20 3319951 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl21-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl25-1 3319935 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl26-1 3319935 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 D cxcl12-ccl28-1 3319935 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 D cxcl12-xcl1-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL1 3319956 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-xcl2-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A XCL2 3319979 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl2-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL2 3319957 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-pf4-2 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 D, Table S2 cxcl12-pf4v1-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL4L1 3319976 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl6-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL6 3319967 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl9-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL9 3319960 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl10-1 3319935 N/A CXCL10 3319961 unspecified role unspecified role prey prey purified purified N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl11-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL11 3319962 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl12-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL12 3319963 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl14-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D cxcl12-cxcl17-1 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 D ccl17-ccl5-5 3319935 N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A CCL5 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false 3319935 Fig. 1 E, Table S2 ccl17-ccl21-1 3319935 N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A CCL21 3319952 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 E ccl17-ccl25-1 3319935 N/A CCL25 3319973 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false direct interaction direct interaction false false false Fig. 1 E ccl17-ccl26-1 3319935 N/A CCL26 3319948 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false direct interaction direct interaction false false false Fig. 1 E ccl17-ccl28-1 3319935 N/A CCL28 3319955 unspecified role unspecified role prey prey purified purified N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false direct interaction direct interaction false false false Fig. 1 E ccl17-pf4-1 3319935 N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A CXCL4 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Fig. 1 E ccl17-cxcl14-1 3319935 N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A CXCL14 3319964 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 E ccl17-cxcl17-1 3319935 N/A CCL17 3319950 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A CXCL17 3319981 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false Fig. 1 E cxcl12-ccl11-2 3319935 N/A CXCL12 3319963 unspecified role unspecified role bait bait purified purified Biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A CCL11 3319976 unspecified role unspecified role prey prey purified purified direct interaction direct interaction false false false 3319935 Fig. 1 D ccl17-ccl5e26a-1 3319936 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified P13501-PRO_0000005175:p.Glu26Ala mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain false CCL5 E26A mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation is remapped to E49A ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CCL17 chip ccl17-ccl5e66a-1 3319936 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified P13501-PRO_0000005175:p.Glu66Ser mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 figure S2 and table S2 CCL17 chip ccl17-ccl5mt7-3 3319936 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified thr7methylation modthr modified L-threonine residue ModThr certain certain sequence position certain certain certain sequence position certain false CCL5 MT7 (N-methylated T7) mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation (methylation) MT7 is remapped to T30me1 methylation decreases strength of binding with a dissociation constant KD = 145 ± 64 nM ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CCL17 chip methylation decreases strength of binding with a dissociation constant KD = 145 ± 64 nM ccl17-ccl544aana47-4 3319936 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified P13501-PRO_0000005175:p.Arg44_Arg47delinsAlaAlaAsnAla Arg67-Arg70delinsAlaAlaAsnAla mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CCL5 44AANA47 mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation 44AANA47 is remapped to 67AANA70 ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CCL17 chip ccl5-pf4cxcl4k50e-1 3319936 N/A 3319987 unspecified role unspecified role prey prey purified purified P02776-PRO_0000351217:p.Lys50Glu Lys50Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CXCL4 K50E mentioned by author is the processed form Platelet factor 4, short form, so the mutation K50E was re-mapped to K97E and the sequence to binding region 48-101 ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319944 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CCL5 chip cxcl12-pf4cxcl4k50e-1 3319936 N/A 3319963 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319987 unspecified role unspecified role prey prey purified purified P02776-PRO_0000351217:p.Lys50Glu Lys97Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CXCL4 K50E mentioned by author is the processed form Platelet factor 4, short form, so the mutation K50E was re-mapped to K97E and the sequence to binding region 48-101 ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CXCL12 chip pf4-ccl5e26a-1 3319936 N/A 3319958 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified P13501-PRO_0000005175:p.Glu26Ala mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CCL5 E26A mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation is remapped to E49A ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false table S2 CXCL4 chip pf4-ccl5mt7-3 3319936 N/A 3319958 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319986 unspecified role unspecified role prey prey purified purified thr30methylation thr30methylation modthr modified L-threonine residue ModThr certain certain sequence position certain certain certain sequence position certain false CCL5 MT7 (N-methylated T7) mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation (methylation) MT7 is remapped to T30me1 methylation obliterated binding P13501-PRO_0000005175:p.Glu66Ser mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false table S2 CXCL4 chip methylation obliterated binding pf4-ccl544aana47-2 3319936 N/A 3319986 unspecified role unspecified role prey prey purified purified P13501-PRO_0000005175:p.Arg44_Arg47delinsAlaAlaAsnAla mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CCL5 44AANA47 mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation 44AANA47 is remapped to 67AANA70 mutation obliterated binding ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319958 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 table S2 CXCL4 chip muation obliterated binding ccl17-ccl5can-2 3319936 N/A 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319944 competitor competitor competitor unspecified role unspecified role purified purified ccl17 binding region ccl17 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false residues K33 to N52 in CCL5 CAN were remapped to residues 56-75 P13501:p.[Cys57Ser;Cys73Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction false false false 3319936 Table S5 ccl51-33-plf4-4 3319936 N/A 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319944 competitor competitor competitor neutral component neutral component purified purified P13501:p.[Glu49Ala;Arg67Ala] mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false CKEY peptide binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false residues K25 to R44 in CKEY CCL5 were remapped to residues 48-67 P13501:p.Val65Ile mutation mutation certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319944 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 Table S5 cxcl12-ccl5-3 3319936 N/A 3319944 competitor competitor competitor unspecified role unspecified role purified purified cxcl12 binding region cxcl12 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false residues K33 to N52 in CCL5 CAN were remapped to residues 56-75 chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319963 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 Table S5 ccl17-ccl5-8 3319936 N/A 3319944 competitor competitor competitor unspecified role unspecified role purified purified ccl17 binding region ccl17 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false residues K33 to N52 in CCL5 CAN were remapped to residues 56-75 chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319944 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319950 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 Table S5 ccl5-pf4-6 3319936 N/A 3319944 unspecified role unspecified role bait bait purified purified biotin tag biotin tag biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 N/A 3319944 competitor competitor competitor neutral component neutral component purified purified cxcl4 binding region CXCL4 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain false residues K25 to R44 in CKEY CCL5 were remapped to residues 48-67 chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319958 unspecified role unspecified role prey prey purified purified ecoli Escherichia coli (strain K12) Stoichiometry: 1.0 direct interaction direct interaction false false false 3319936 Table S5 ccl5e66s-pf4k50enmr-1 3319937 N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319987 unspecified role unspecified role neutral component neutral component purified purified P02776-PRO_0000351217:p.Lys50Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CXCL4 K50E mentioned by author is the processed form Platelet factor 4, short form, so the mutation K50E was re-mapped to K97E and the sequence to binding region 48-101 ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure 2A+C+E, S3A, S4A+B+E+F+G+H, S5 ccl5e66snmr-cxcl12-3 3319937 N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S ecoli Escherichia coli (strain K12) N/A 3319963 unspecified role unspecified role neutral component neutral component purified purified 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S7A+B ccl17-ccl5e66anmr-2 3319937 N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure 2B+D+F, S3B, S4C+D, S6 ccl17-ccl5-1 3319937 N/A 3319944 unspecified role unspecified role neutral component neutral component purified purified P13501:p.[Cys57Ser;Cys73Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S10 ccl5-pf4-1 3319937 N/A 3319944 competitor competitor competitor neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P13501:p.Val65Ile mutation mutation certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319987 unspecified role unspecified role neutral component neutral component purified purified P02776-PRO_0000351217:p.Lys50Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CXCL4 K50E mentioned by author is the processed form Platelet factor 4, short form, so the mutation K50E was re-mapped to K97E and the sequence to binding region 48-101 ecoli Escherichia coli (strain K12) N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S9 ccl5-cxcl12-3 3319937 N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319963 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S7C+D ccl17-ccl5-10 3319937 N/A 3319944 competitor competitor competitor neutral component neutral component purified purified P13501:p.[Cys57Ser;Cys73Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain false certain certain sequence position certain certain certain sequence position certain false region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false chemical synthesis Chemical synthesis (Chemical synthesis) N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the N-terminal processed form RANTES(3-68) produced by proteolytic cleavage, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S11 ccl5-ccl5-4 3319937 N/A 3319987 unspecified role unspecified role neutral component neutral component purified purified P02776-PRO_0000351217:p.Lys50Glu mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain false CXCL4 K50E mentioned by author is the processed form Platelet factor 4, short form, so the mutation K50E was re-mapped to K97E and the sequence to binding region 48-101 ecoli Escherichia coli (strain K12) N/A 3319986 unspecified role unspecified role neutral component neutral component purified purified P13501-PRO_0000005175:p.Glu66Ser mutation mutation certain certain sequence position certain certain certain sequence position certain false CCL5 E66A mentioned by author is the processed form RANTES(3-68) produced by proteolytic cleavage and remapped to residues 26–91, and the mutation is remapped to E89S 15N label 15n label 15n label 15N N15 15N N15 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Figure S9 ccr5_ccl17-1 3319938 N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319988 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. physical association physical association false false false Fig. 4E ccl17-ccl5-11 3319938 N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319950 competitor competitor competitor neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 3319988 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. association association false false false Fig. 4E Binding competition assays revealed that the affinity of CCL17 for CCR4 was higher when adding CCL5 but not CXCL1, to promote heterodimer formation (Fig. 4E and fig. S17F). ccl17-ccr5-2 3319938 N/A 3319989 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 3319950 competitor competitor competitor neutral component neutral component purified purified N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) association association false false false Fig. S17F ccl17-ccl17-1 3319938 N/A 3319989 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. N/A 3319950 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) physical association physical association false false false Fig. S17F ccl17-ccl17-2 3319938 N/A 3319944 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319944 competitor competitor competitor neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 3319990 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. association association false false false Fig. S18D ccl17-ccl17-3 3319938 N/A 3319944 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319990 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. physical association physical association false false false Fig. S18D ccl5-ccl5-5 3319938 N/A 3319944 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319944 competitor competitor competitor neutral component neutral component purified purified ecoli Escherichia coli (strain K12) N/A 3319988 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. association association false false false Fig. S18E ccl5-ccr1-1 3319938 N/A 3319944 unspecified role unspecified role neutral component neutral component purified purified alexa Fluor 647 alexa label alexa label undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 3319988 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. physical association physical association false false false Fig. S18E ccl17-ccr5-1 3319939 N/A 3319991 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319992 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S17D CCL5/CCL17 heterodimer ccl5-ccr5-4 3319939 N/A 3319991 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S17B CCL5/CCL17 heterodimer CCL17 ccl17-ccr4-1 3319939 N/A 3319994 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319992 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S17A CCL5 CCL5/CCL17 heterodimer ccl5-ccr4-1 3319939 N/A 3319994 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S17C CCL5/CCL17 heterodimer ccl17-ccl5-3 3319939 N/A 3319992 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. 4A, 4B CCL5/CCL17 heterodimer ccr4-ccr5-1 3319939 N/A 3319994 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319991 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. 4A, 4C CCL5/CCL17 heterodimer ccl5-ccl17-3 3319940 N/A 3319944 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed met-RANTES sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P13501:p.Ala23Met mutation mutation certain certain sequence position certain certain certain sequence position certain false N/A 3319992 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S16A ccl5-pf4-4 3319940 N/A 3319995 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed N/A 3319944 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed met-RANTES sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false P13501:p.Ala23Met mutation mutation certain certain sequence position certain certain certain sequence position certain false proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S16B ccl17-ccl5-7 3319940 N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319992 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S16A ccl5-pf4-5 3319940 N/A 3319995 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S16B ccl17-ccl5-2 3319941 N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319992 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. S16C ccl17-ccl5-4 3319942 N/A 3319944 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319950 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. 6 This interaction was not seen in not in undiseased vessels or segments. ccl17-ccl5-9 3319943 N/A 3319993 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level N/A 3319992 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level proximity proximity close-contact colocalization neighbourhood interaction false false false Fig. 6