IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ agullo_pascual-2013-1 Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. rat-cardiac_myocytes_neo rat cardiac myocytes neo neonatal_ventricular_myocyte neonatal ventricular myocyte A heart muscle cell. fluorescence imaging fluorescence microscopy fluorescence imaging immunocytochemistry immunocytochemistry Agullo-Pascual E., Reid D.A., Keegan S., Sidhu M., Fenyö D., Rothenberg E., Delmar M. Cardiac - Interactions involving cardiac related proteins SRFM -Super-resolution fluorescence microscopy. Neonatal rat ventricular myocytes mario.delmar@nyumc.org,eli.rothenbreg@nyumc.org,david@fenyolab.org Cardiovasc. Res. (0008-6363) 2013 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. agullo_pascual-2013-2 Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. rat-heart Rattus norvegicus heart heart Heart [Cardiac; Cardiac tissue] pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Agullo-Pascual E., Reid D.A., Keegan S., Sidhu M., Fenyö D., Rothenberg E., Delmar M. Cardiac - Interactions involving cardiac related proteins mario.delmar@nyumc.org,eli.rothenbreg@nyumc.org,david@fenyolab.org Cardiovasc. Res. (0008-6363) 2013 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. agullo_pascual-2013-3 Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque. mouse-heart Mus musculus heart [Cardiac; Cardiac tissue] heart Heart [Cardiac; Cardiac tissue] pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Agullo-Pascual E., Reid D.A., Keegan S., Sidhu M., Fenyö D., Rothenberg E., Delmar M. Cardiac - Interactions involving cardiac related proteins adult mouse cardiac ventricle tissue mario.delmar@nyumc.org,eli.rothenbreg@nyumc.org,david@fenyolab.org Cardiovasc. Res. (0008-6363) 2013 Only protein-protein interactions imex curation Affinomics - Interactions curated for the Affinomics consortium. q562c0_rat Pkp2 protein protein rat Rattus norvegicus (Rat) Rat PEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKVMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKVKEQYQDTPMPEERSSPRGIEWLWHSIVIRMYLSLIAKSSRNYTQEASLGALQNLTAGSGPIPTSVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHNAYKKAQFKKTDFVNSRTAKASHSLKD cxa1_rat Gap junction alpha-1 protein Gja1 Cxn-43 Connexin-43 Gap junction 43 kDa heart protein protein protein rat Rattus norvegicus (Rat) Rat MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDNQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI q9cq73_mouse Pkp2 protein protein mouse Mus musculus Mouse MAVPGSLAECGYIRTVLGQQILGHLDSSSLALPSEARLRLAGSSGRGDPAARSQRIQEQVQQTLARRGRSSAVSGNLHRTSSVPEYVYKLHVVENDFVGRQSPVTRDYDMLKAGMTATYGSRWGRAAAQYSSQKSVEERSWRQPLRRLEISPDSSPERAHYGHSEYQYAWRSHVVPGGRLTLPRYARSEILGLRQAGTARRPPGCGSFSDAVFDNGPLKPTMPTHPPGTSHSAGSLLEETTVRVSQARLQSTQSRTARSSWPRSSVRSSLREPGRMLTTAGQAAVGSGDAHGDRSVFADAQLGNADIEMTLERAVNMLDADHVPVSKISAAATFIQHESFQKSEARKRVNQLRGIPKLLQLLKLQNEDVQRAACGALRNLVFEDNDNKLEVAELNGVPRLLQVLKQTRDLETKKQITGLLWNLSSSDKLKHLMITEALLTLTESVIIPFSGWPEGDYPKANGLLDFDIFYNVTGCLRNMSSAGPDGRKMMRRCDGLIDSLVHYVRGTIADYQPDDKATENCVCILHNLSYQLEAELPEKYSQSIYMQNRNIQTNSNKSIGCFGSRSRKLKEQYQDLQMPEERSNPHGIEWLWHSIVIRMYLSLIAKSTRNYTQEASLGALQNLTAGGGPIPTLVARMVVQKENGLQHTRKMLHVGDPSVKKTAVSLLRNLSRNLSLQNEIAKETLPDLVSIIPDTVPSTDLLIETTASACYTLNNLMQNSYQNARDLLNTGGLQKIMTISIGEGYAPNKASKAASVLLYSLWAHTELHHAYKKAQFKKTDFVNSRTAKAYHSLKD mint cxa1_mouse Gap junction alpha-1 protein Gja1 Cxn-43 Connexin-43 Gap junction 43 kDa heart protein protein protein mouse Mus musculus Mouse MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI gja1-pkp2 1567478 n/a 1567481 unspecified role unspecified role neutral component neutral component n/a 1567482 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 1,2,3,4 The size of the Cx43-PKP2 co-localization area was significantly affected by the absence of AnkG. In cells lacking AnkG expression the area of co-localization with PKP2 varied over a wider range than controls, allowing the formation of larger sized plaques. gja1-pkp2-1 1567479 n/a 1567482 unspecified role unspecified role neutral component neutral component n/a 1567481 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 6A The size of the Cx43-PKP2 co-localization area was significantly affected by the absence of AnkG. In cells lacking AnkG expression the area of co-localization with PKP2 a varied over a wider range than controls, allowing the formation of larger sized plaques. gja1-pkp2-2 1567480 n/a 1567483 unspecified role unspecified role neutral component neutral component n/a 1567484 unspecified role unspecified role neutral component neutral component proximity proximity close-contact colocalization neighbourhood interaction false false false 6