IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ jimenez_cer-1998-1 Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. mouse-b16 Mus musculus melanoma tumor maintained in mouse. b16 mouse skin melanoma tumor maintained in C57/B1 mouse molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Jimenez-Cervantes C., Martinez-Esparza M., Solano F., Lozano JA., Garcia-Borron JC. Cancer - Interactions investigated in the context of cancer The melanosome-rich fraction was obtained by differential centrifugation of tumor homogenates which were extracted to give solubilized preparations. Chromatography performed on a Sephacryl S300 column. 1 and 2 gborron@fcu.um.es Biochem. Biophys. Res. Commun. (0006-291X) 1998 Only protein-protein interactions imex curation jimenez_cer-1998-2 Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. mouse-b16 Mus musculus melanoma tumor maintained in mouse. b16 mouse skin melanoma tumor maintained in C57/B1 mouse fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret predetermined predetermined participant predetermined Jimenez-Cervantes C., Martinez-Esparza M., Solano F., Lozano JA., Garcia-Borron JC. Cancer - Interactions investigated in the context of cancer The melanosome-rich fraction was obtained by differential centrifugation of tumor homogenates which were extracted to give solubilized preparations. Chromatography performed on a Sephacryl S300 column. 1 and 2 gborron@fcu.um.es Biochem. Biophys. Res. Commun. (0006-291X) 1998 Only protein-protein interactions imex curation tyro_mouse Tyrosinase Monophenol monooxygenase Albino locus protein Tyr protein protein mouse Mus musculus Mouse MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL tyrp1_mouse 5,6-dihydroxyindole-2-carboxylic acid oxidase Tyrosinase-related protein 1 Catalase B Brown locus protein Tyrp1 Tyrp-1 protein protein mouse Mus musculus Mouse MKSYNVLPLAYISLFLMLFYQVWAQFPRECANIEALRRGVCCPDLLPSSGPGTDPCGSSSGRGRCVAVIADSRPHSRHYPHDGKDDREAWPLRFFNRTCQCNDNFSGHNCGTCRPGWRGAACNQKILTVRRNLLDLSPEEKSHFVRALDMAKRTTHPQFVIATRRLEDILGPDGNTPQFENISVYNYFVWTHYYSVKKTFLGTGQESFGDVDFSHEGPAFLTWHRYHLLQLERDMQEMLQEPSFSLPYWNFATGKNVCDVCTDDLMGSRSNFDSTLISPNSVFSQWRVVCESLEEYDTLGTLCNSTEGGPIRRNPAGNVGRPAVQRLPEPQDVTQCLEVRVFDTPPFYSNSTDSFRNTVEGYSAPTGKYDPAVRSLHNLAHLFLNGTGGQTHLSPNDPIFVLLHTFTDAVFDEWLRRYNADISTFPLENAPIGHNRQYNMVPFWPPVTNTEMFVTAPDNLGYAYEVQWPGQEFTVSEIITIAVVAALLLVAAIFGVASCLIRSRSTKNEANQPLLTDHYQRYAEDYEELPNPNHSMV tyro-tyro-1 Homodimerisation of mouse tyrosinase 314649 N/A 314651 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse N/A 314651 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse direct interaction direct interaction false false false trp1-trp1-1 Homodimerisation of mouse tyrosinase-related protein 1 314649 N/A 314652 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse N/A 314652 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse direct interaction direct interaction false false false tyro-trp1-1 Interaction between mouse tyrosinase and tyrosinase-related protein 1 314649 N/A 314652 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse N/A 314651 unspecified role unspecified role neutral component neutral component mouse Mus musculus Mouse direct interaction direct interaction false false false tyro-trp1-2 Interaction between mouse tyrosinase and tyrosinase-related protein 1 detected by FRET 314650 N/A 314652 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept region dye labelled dye label dye labelled undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false mouse Mus musculus Mouse N/A 314651 unspecified role unspecified role fluorescence donor fluorescence donor region fitc labelled fluorescein isothiocyanate label fluorescein isothiocyanate labbeled FITC labelled FITC labelled fluorescein isothiocyanate labbeled fitc labelled undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false mouse Mus musculus Mouse direct interaction direct interaction false false false