IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ http://www.ebi.ac.uk/ cerezo-2016-5 human-melanoma Human melanoma melanoma Melanoma anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-1 in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-2 human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-3 human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 fluorescence imaging fluorescence microscopy fluorescence imaging immunocytochemistry immunocytochemistry Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. HA15 was detected/visualized after excitation at 405 nm. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-4 in vitro In vitro pull down pull down sequence tag sequence tag identification sequence tag Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-7 human-melanoma Human melanoma melanoma Melanoma fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret tag fluorescence tag visualisation by fluorescence tag fluorescence Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-8 in vitro In vitro dsc differential scanning calorimetry dsc predetermined predetermined participant predetermined Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions cerezo-2016-9 in vitro In vitro itc isothermal titration calorimetry ITC ITC itc predetermined predetermined participant predetermined Cerezo M., Lehraiki A., Millet A., Rouaud F., Plaisant M., Jaune E., Botton T., Ronco C., Abbe P., Amdouni H., Passeron T., Hofman V., Mograbi B., Dabert-Gay AS., Debayle D., Alcor D., Rabhi N., Annicotte JS., Héliot L., Gonzalez-Pisfil M., Robert C., Moréra S., Virougoux A., Gual P., Ali MM., Bertolotto C., Hofman P., Ballotti R., Benhida R., Rocchi S. Cancer - Interactions investigated in the context of cancer As the authors have not replied to a request for information:- Results from a FRET experiment - Supplementary Figure 3A, have not been included as no cell line is stated here and associated references give several different cell lines. Interactions involving recombinant IRE1-alpha have not been entered as the species of origin is not given. It has been assumed that the protein BiP (GRP-78/HSPA5) is of Human origin in all constructs used; however this has not been confirmed by the authors. BiP-NBD has been assumed to be the "Nucleotide binding domain" amino acids 26-410 as given in the PDB entry 3iuc, referenced by Addgene plasmid 42447. benhida@unice.fr,srocchi@unice.fr Cancer cell 2016 imex curation Only protein-protein interactions bip_human Endoplasmic reticulum chaperone BiP HSPA5 GRP78 Immunoglobulin heavy chain-binding protein 78 kDa glucose-regulated protein Binding-immunoglobulin protein Heat shock protein 70 family protein 5 Heat shock protein family A member 5 protein protein human Homo sapiens Human MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL e2ak3_human Eukaryotic translation initiation factor 2-alpha kinase 3 PRKR-like endoplasmic reticulum kinase Pancreatic eIF2-alpha kinase EIF2AK3 PEK PERK protein protein human Homo sapiens Human MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVPAAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDPENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVESLLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQRTQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEEQEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTSYTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNENAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGYYLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIVRRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN atf6a_human Cyclic AMP-dependent transcription factor ATF-6 alpha Activating transcription factor 6 alpha ATF6 protein protein human Homo sapiens Human MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNLDFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEELDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQPKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTVVQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNVGSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLDEVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLGFSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLNHELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGSELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAININENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATHVVSTIPESLQ ern1_human Serine/threonine-protein kinase/endoribonuclease IRE1 ERN1 Inositol-requiring protein 1 Ire1-alpha Endoplasmic reticulum-to-nucleus signaling 1 IRE1 protein protein human Homo sapiens Human MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL ha15 HA15 small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) rack1_human Receptor of activated protein C kinase 1 Small ribosomal subunit protein RACK1 HLC7 PIG21 RACK1 Cell proliferation-inducing gene 21 protein GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1 Guanine nucleotide-binding protein subunit beta-like protein 12.3 Human lung cancer oncogene 7 protein Receptor for activated C kinase protein protein human Homo sapiens Human MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR actn4_human Alpha-actinin-4 ACTN4 Non-muscle alpha-actinin 4 protein protein human Homo sapiens Human MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL aldoa_human Fructose-bisphosphate aldolase A Muscle-type aldolase Lung cancer antigen NY-LU-1 ALDOA ALDA protein protein human Homo sapiens Human MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY tba1b_human Tubulin alpha-1B chain TUBA1B Tubulin alpha-ubiquitous chain Alpha-tubulin ubiquitous Tubulin K-alpha-1 protein protein human Homo sapiens Human MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY tba1c_human Tubulin alpha-1C chain TUBA1C TUBA6 Tubulin alpha-6 chain Alpha-tubulin 6 protein protein human Homo sapiens Human MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGADSADGEDEGEEY actg_human Actin, cytoplasmic 2 ACTG1 ACTG Gamma-actin protein protein human Homo sapiens Human MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF actn1_human Alpha-actinin-1 ACTN1 Alpha-actinin cytoskeletal isoform Non-muscle alpha-actinin-1 F-actin cross-linking protein protein protein human Homo sapiens Human MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL ldhb_human L-lactate dehydrogenase B chain LDHB LDH heart subunit Renal carcinoma antigen NY-REN-46 protein protein human Homo sapiens Human MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL anxa5_human Annexin A5 ANXA5 ANX5 ENX2 PP4 Annexin-5 Annexin V Lipocortin V Endonexin II Calphobindin I Placental anticoagulant protein I Placental anticoagulant protein 4 Thromboplastin inhibitor Vascular anticoagulant-alpha Anchorin CII protein protein human Homo sapiens Human MAQVLRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGEDD rs4x_human 40S ribosomal protein S4, X isoform RPS4X CCG2 RPS4 SCAR Single copy abundant mRNA protein SCR10 Small ribosomal subunit protein eS4 protein protein human Homo sapiens Human MARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG clic1_human Chloride intracellular channel protein 1 CLIC1 NCC27 Nuclear chloride ion channel 27 Chloride channel ABP Regulatory nuclear chloride ion channel protein G6 protein protein human Homo sapiens Human MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK 1433z_human 14-3-3 protein zeta/delta YWHAZ Protein kinase C inhibitor protein 1 protein protein human Homo sapiens Human MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN if4a1_human Eukaryotic initiation factor 4A-I EIF4A1 EIF4A DDX2A ATP-dependent RNA helicase eIF4A-1 protein protein human Homo sapiens Human MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI enoa_human Alpha-enolase ENO1 ENO1L1 MBPB1 MPB1 2-phospho-D-glycerate hydro-lyase Non-neural enolase Enolase 1 Phosphopyruvate hydratase C-myc promoter-binding protein MBP-1 MPB-1 Plasminogen-binding protein protein protein human Homo sapiens Human MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK clh1_human Clathrin heavy chain 1 Clathrin heavy chain on chromosome 17 CLTC CLH17 KIAA0034 CLTCL2 protein protein human Homo sapiens Human MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM tbb3_human Tubulin beta-3 chain TUBB3 TUBB4 Tubulin beta-III Tubulin beta-4 chain protein protein human Homo sapiens Human MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEMYEDDEEESEAQGPK pgam1_human Phosphoglycerate mutase 1 Phosphoglycerate mutase isozyme B BPG-dependent PGAM 1 PGAM1 CDABP0006 PGAMA protein protein human Homo sapiens Human MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK 1433e_human 14-3-3 protein epsilon YWHAE protein protein human Homo sapiens Human MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ ef2_human Elongation factor 2 EEF2 EF2 protein protein human Homo sapiens Human MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFYELSENDLNFIKQSKDGAGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIISTYGEGESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKVEDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFKKEETAKLIEKLDIKLDSEDKDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCELLYEGPPDDEAAMGIKSCDPKGPLMMYISKMVPTSDKGRFYAFGRVFSGLVSTGLKVRIMGPNYTPGKKEDLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETVSEESNVLCLSKSPNKHNRLYMKARPFPDGLAEDIDKGEVSARQELKQRARYLAEKYEWDVAEARKIWCFGPDGTGPNILTDITKGVQYLNEIKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHADAIHRGGGQIIPTARRCLYASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQILPGDPFDNSSRPSQVVAETRKRKGLKEGIPALDNFLDKL eif2ak3-hspa5-2 2824152 N/A 2824160 unspecified role unspecified role prey prey N/A 2824161 unspecified role unspecified role bait bait physical association physical association false false false Supp 2 C/D HA15 (CHEBI:132781) hspa5-atf6-1 2824152 N/A 2824162 unspecified role unspecified role bait bait N/A 2824160 unspecified role unspecified role prey prey physical association physical association false false false Supp 2 C HA15 (CHEBI:132781) ern1-hspa5-4 2824152 N/A 2824160 unspecified role unspecified role prey prey N/A 2824163 unspecified role unspecified role bait bait physical association physical association false false false Supp 2 C/D HA15 (CHEBI:132781) ern1-hspa5-5 2824152 N/A 2824160 unspecified role unspecified role prey prey region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 2824160 unspecified role unspecified role prey prey N/A 2824163 unspecified role unspecified role bait bait physical association physical association false false false Supp 2 C/Di HA15 (CHEBI:132781) It is stated that the addition of recombinant BiP competes and diminishes dissociation of endogenous cellular BiP from PERK and IRE1-alpha. eif2ak3-hspa5-3 2824152 N/A 2824160 unspecified role unspecified role prey prey region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 2824160 unspecified role unspecified role prey prey N/A 2824161 unspecified role unspecified role bait bait physical association physical association false false false Supp 2 C/Dii HA15 (CHEBI:132781) It is stated that the addition of recombinant BiP competes and diminishes dissociation of endogenous cellular BiP from PERK and IRE1-alpha. ha15-hspa5-8 2824153 N/A 2824160 unspecified role unspecified role prey prey region his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false ecoli Escherichia coli (strain K12) N/A 2824164 unspecified role unspecified role bait bait region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false direct interaction direct interaction false false false 3B ha15-hspa5-1 2824153 N/A 2824160 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824164 unspecified role unspecified role bait bait region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false 3C ha15-hspa5-4 2824153 N/A 2824160 unspecified role unspecified role prey prey human-melanoma Human melanoma melanoma Melanoma N/A 2824164 unspecified role unspecified role bait bait region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false physical association physical association false false false Supp 2B ha15-hspa5-2 2824154 N/A 2824160 unspecified role unspecified role prey prey N/A 2824161 unspecified role unspecified role bait bait physical association physical association false false false 3D HA15 (CHEBI:132781) eif2ak3-hspa5-1 2824154 N/A 2824160 unspecified role unspecified role prey prey N/A 2824163 unspecified role unspecified role bait bait physical association physical association false false false 3D-2 HA15 (CHEBI:132781) ern1-hspa5-3 2824154 N/A 2824162 unspecified role unspecified role prey prey N/A 2824160 unspecified role unspecified role bait bait physical association physical association false false false 3D-3 HA15 (CHEBI:132781) ha15-hspa5-3 2824155 N/A 2824164 unspecified role unspecified role neutral component neutral component region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 2824160 unspecified role unspecified role neutral component neutral component colocalization colocalization false false false 3E ha15-hspa5-5 2824156 N/A 2824165 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824166 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824167 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824168 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824169 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824170 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824160 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824164 unspecified role unspecified role bait bait region biotin tag biotin tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false N/A 2824171 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824172 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824173 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824174 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824175 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824176 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824177 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824178 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824179 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824180 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824181 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824182 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 N/A 2824183 unspecified role unspecified role prey prey human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 association association false false false Table 1 24w5t-1 2824157 N/A 2824164 predetermined predetermined participant predetermined unspecified role unspecified role fluorescence donor fluorescence donor N/A 2824160 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined false proximity proximity close-contact colocalization neighbourhood interaction false false false Supp 3A ha15-hspa5-6 2824158 N/A 2824164 unspecified role unspecified role neutral component neutral component N/A 2824160 unspecified role unspecified role neutral component neutral component n_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false nbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Supp 3B ha15-hspa5-7 2824159 N/A 2824164 unspecified role unspecified role neutral component neutral component N/A 2824160 unspecified role unspecified role neutral component neutral component n_terminus his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range false nbd sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain false ecoli Escherichia coli (strain K12) direct interaction direct interaction false false false Supp 3C